Chordoid glioma of the third ventricle

Abstract

Mortality in the immediate postoperative period is 32% and is higher after gross total resection as compared to subtotal resection. Non-fatal postoperative complications are hypothalamic disorders and mental alterations. Gross total resection is the treatment of choice since no recurrence has been reported after macroscopically complete resection, but this is often difficult because of the location and adherence to the hypothalamus. The role of postoperative radiotherapy is uncertain. There is some indication that radiosurgery with or without conventional irradiation is superior to conventional radiation alone. Planned subtotal resection followed by stereotactic radiosurgery can be a safe and effective alternative in a patient in whom gross total resection is considered to be too risky. There is no report on the use of chemotherapy in the treatment of chordoid gliomas. More information about the optimal treatment strategy is needed, and more reports are also needed.

Chordoid Glioma : A Case Report of Unusual Location and Neuroradiological Characteristics

“…Poor prognosis might be due to the tumor location in the deep structure of the brain, making it difficult to approach surgically. The possible cause of death and unfortunate poor prognosis of our case is consistent with previously reported cases 9,11,17,25,28) .…”

“…Radiological findings from neuroimaging studies of this tumor were also consistent and typical, in that they characteristically exhibit a well-circumscribed border, uniform contrast enhancement, and a fusiform gross morphology 2,19,27,28) . On the histological side, it was cautiously suggested that the tumor showed features of ependymal differentiation 6,19,23,25) .…”

“…Such a clinical course is in line with previous reports. Vanhauwaert et al 28) reported overall immediately postoperative mortality rate was about 30% through the literature reviews. They were considered to have had a thromboembolism or to suffer from hypothalamic injury.…”

“…From then on, approximately 50 cases of chordoid glioma, to our best knowledge, have been reported [1][2][3][4][5]7,8,[11][12][13][14][15][16][17][18][20][21][22][23]25,28) . Chordoid glioma is a rare lowgrade tumor of the brain, most of which are known to be located in the third ventricle, frequently attached to the hypothalamic or suprasellar area.…”

Therapeutic Approach to Chordoid Glioma of the Third Ventricle

“…10,18,21) Among 54 of 55 patients treated by surgery, 27 had gross total removal (GTR), 22 had partial removal (PR), and 5 cases were biopsied. No recurrence was reported for a long duration after GTR, 5,8,12,28,39) but five patients (22.7%) had recurrence after PR. GTR carries significant risk because of the close relationship between the tumor and the critical organs nearby.…”