Chordoid glioma: Case report and review of the literature

Morais, Bárbara Albuquerque; Menendez, Djalma F.S.; Medeiros, Raphael Salles Scortegagna de; Teixeira, Manoel J.; Lepski, Guilherme

doi:10.1016/j.ijscr.2015.01.027

Cited by 28 publications

(18 citation statements)

References 15 publications

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“…In one patient with progression, extent of resection for initial resection was not reported. [56] Four patients had repeat resections for progressive disease following initial surgery. [16, 19, 29, 56].…”

Section: Resultsmentioning

confidence: 99%

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Prognostic factors for recurrence and complications in the surgical management of primary chordoid gliomas: A systematic review of literature

Ampie

Choy

Lamano

et al. 2015

Clinical Neurology and Neurosurgery

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Introduction Chordoid Gliomas (CG) are rare neoplasms which frequently arise within the third ventricle. Surgery remains the mainstay treatment for CG. The present study comprehensively reviews all reported cases of CG within the literature in order to identify risk factors for surgical complications and tumor recurrence. Methods A comprehensive search on MEDLINE (OVID and Pubmed), Scopus, Embase, and Web of Science was conducted following PRISMA guidelines to identify all reported cases of CG. Results A total of 81 patients met the study criteria, comprised of 33 males and 48 females. Median age at diagnosis was 48 years with a range from 5 to 72 years, and mean tumor size was 3.1 cm. Biopsy, subtotal resection (STR), and gross total resection (GTR) was achieved in 8, 34, and 33 patients, respectively, with 6 cases not reporting extent of eresection (EOR). Thirteen patients underwent adjuvant radiotherapy. Postoperative complications were noted in 30 cases (37%), with new onset diabetes insipidus being the most common. Postoperative morbidity was not associated with age, tumor size, or extent of resection. A trans-lamina terminalis approach demonstrated a strong trend towards decreased overall rates of postoperative morbidity compared to other approaches (p=0.051). GTR was associated with improved progression-free survival (PFS; p=0.028), while adjuvant radiotherapy, age, tumor size and MIB-I were not predictive of patient outcomes. Conclusion GTR should be the primary goal for the management of CG, as it is associated with improved rates of tumor control without an increased rate of postoperative complications. Surgical approach was a stronger predictor of complication rates than extent of resection. Morbidity remains high, and future studies to further elaborate on factors predictive of postoperative complications are critical.

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Section: Resultsmentioning

confidence: 99%

“…[56] Four patients had repeat resections for progressive disease following initial surgery. [16, 19, 29, 56]. Of these, 2 later died from causes unrelated to disease, and 1 remains disease free at 29 months of follow up.…”

Section: Resultsmentioning

confidence: 99%

Prognostic factors for recurrence and complications in the surgical management of primary chordoid gliomas: A systematic review of literature

Ampie

Choy

Lamano

et al. 2015

Clinical Neurology and Neurosurgery

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“…Typically these tumors are well circumscribed, round or oval in shape on T1W MR (63%) of cases and slightly hyperintense on T2W images, with homogeneous enhancement by gadolinium (70%). Most tumors are solid, but cystic changes are infrequently seen within the periphery of these tumors [8].…”

Section: Discussionmentioning

confidence: 99%

“…Gross total resection (GTR) is the ideal treatment, although tumor size and location often impede radical resection. Radiotherapy has largely been reserved as adjunctive therapy for management of residual tumor following resection [3,8].…”

Section: Discussionmentioning

confidence: 99%

“…After partial resection, mortality and morbidity decreased to 14% and 50%, respectively. The most common postoperative complication reported are cognitive disorders, pulmonary embolism and hypothalamic dysfunction (DI, SIADH, weight gain, hypothyroidism and panhypopituitarism) [3,8]. The rate of 1-, 3-and 5-year progression free survival (PFS) was 88.4%, 82.5%, and 70.7%, respectively.…”

Section: Discussionmentioning

confidence: 99%

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Chordoid Glioma of Third Ventricle Presenting as Primary Polydipsia With Aggressive Behavior: A Rare Case With Rare Presentation

Gupta

Khan

et al. 2017

J Neurol Res

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Chordoid glioma of third ventricle is relatively rare and characterized by unique histomorphology and varied clinical presentation. Chordoid glioma has high morbidity and high mortality rates despite being low grade tumor because of insidious presentation and difficulty in complete resection. Here, we report a new case of chordoid glioma occurring in a 32-year-old male, who presented with polyuria, polydipsia and behavioral problems, and on the water deprivation test diagnosis of primary polydipsia was made. MRI revealed tumor of third ventricle, which was resected subtotally. Diagnosis of chordoid glioma was confirmed by histology and immunohistochemical analysis of resected tumor. Recurrence of chordoid glioma was reported on MRI after 2.5 months. Based on this case report, we suggest chordoid glioma should be kept in differential diagnosis of primary polydipsia.

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Assessment of magnetic resonance imaging and histopathological changes in chordoid glioma: A retrospective analysis of 13 cases

Huang,

Deng,

Wen

et al. 2024

Int J Imaging Syst Tech

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Chordoid glioma (CG) is a rare tumor, and its predominantly anterior location is in the third ventricle. However, the clinical characteristics of CG were not obvious, and there was less knowledge of CG‐related imaging. This study aimed at exploring the MRI imaging features of CG. We retrospectively analyzed the MRI data of 13 patients diagnosed with CG from January 2015 to May 2021. The pathological change of tumor tissue was observed using H&E staining and immunohistochemical. The MRI manifestations of CG often include phyllode masses in the anterior part of the third ventricle. T2WI is dominated by iso‐ and hypointensity, with internal patchy hyperintensity, marked enhancement, and peritumoral edema. The “eight‐character edema sign” runs along the optic beam and may be useful for distinguishing CG from other tumors. CG has unique MRI manifestations that can serve as a diagnostic basis. Our study may help to enhance the understanding of imaging about CG and improve the diagnosis of patients with CG.

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Chordoid glioma: Case report and review of the literature

Cited by 28 publications

References 15 publications

Prognostic factors for recurrence and complications in the surgical management of primary chordoid gliomas: A systematic review of literature

Prognostic factors for recurrence and complications in the surgical management of primary chordoid gliomas: A systematic review of literature

Chordoid Glioma of Third Ventricle Presenting as Primary Polydipsia With Aggressive Behavior: A Rare Case With Rare Presentation

Assessment of magnetic resonance imaging and histopathological changes in chordoid glioma: A retrospective analysis of 13 cases

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