This study was conducted in order to evaluate the potential of different plant extracts (guava Psidiumguajava, annatto Bixaorellana, red sage Lantana camara and jambolanSyzygiumcumini) against Trichodinaspp. of Nile tilapia fingerlings.Initial parasite abundance and prevalence was compared after two-day treatment using a commercial antiparasitic drug and plant extracts (50 mg/L). Percent prevalences of Trichodina spp. in the gills, skin and fins remained very high (93.30 to 100.00%) after two days treatment. Extracts from annatto (128.1±97.8), red sage (178.4±209.5), guava (52.3±75.9) and jambolan (56.1±71.7), and the commercial anti-parasitic drug (163.7±101.5) were significantly effective in reducing the abundance of Trichodina spp. in the gills of Nile tilapia fingerlings as compared to the initial abundance(215.2±190.1). Except jambolan (26.9±34.8), plant extracts from guava (9.3±10.1), annatto (16.2±12.3) and red sage (16.8±21.4) were also found effective in decreasing the initial abundance (25.7±21.9) of skin and fins Trichodina spp. Commercial anti-parasitic drug was not successful in controlling the parasite in the skin and fins of tilapia fingerlings.