Choosing the types of biological sample to collect in longitudinal birth cohort studies

Golding, Jean

doi:10.1111/j.1365-3016.2008.01000.x

Cited by 20 publications

(33 citation statements)

References 76 publications

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“…A key aspect of such investigations might be the measurement of endogenous hormones in early life. However, collecting multiple biological samples in well children is usually difficult; most studies reporting hormone levels have few samples, involved hospitalized children, or use pooling or other methods 6 .…”

Section: Introductionmentioning

confidence: 99%

Sex Hormones, Gonadotropins, and Sex Hormone-binding Globulin in Infants Fed Breast Milk, Cow Milk Formula, or Soy Formula

Fang

Wang

et al. 2017

Sci Rep

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Measurement of endogenous hormones in early life is important to investigate the effects of hormonally active environmental compounds. To assess the possible hormonal effects of different feeding regimens in different sample matrices of infants, 166 infants were enrolled from two U.S hospitals between 2006 and 2009. The children were classified into exclusive soy formula, cow milk formula or breast milk regimens. Urine, saliva and blood samples were collected over the first 12 months of life. Estradiol, estrone, testosterone, luteinizing hormone (LH), follicle-stimulating hormone (FSH) and sex hormone-binding globulin (SHBG) levels were measured in the three matrices. Lower estradiol and LH levels were found in urine and saliva samples of soy formula-fed boys compared to cow formula-fed boys. Higher LH level was found in urine samples of soy formula-fed girls compared to cow formula-fed girls. However, we found neither a neonatal testosterone rise in the boys nor a gender-specific difference in testosterone levels, which suggests that urinary testosterone levels may not accurately reflect blood levels during mini-puberty. Nevertheless, our study shows that blood, urine and saliva samples are readily collectible and suitable for multi-hormone analyses in children and allow examination of hypotheses concerning endocrine effects from dietary compounds.

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Section: Introductionmentioning

confidence: 99%

Sex Hormones, Gonadotropins, and Sex Hormone-binding Globulin in Infants Fed Breast Milk, Cow Milk Formula, or Soy Formula

Fang

Wang

et al. 2017

Sci Rep

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“…[2][3][4][5] The assessment of the prenatal environment will rely on the interview with the mother and the collection of biological samples at the child's birth. 4,6 A pilot study was carried out in October 2007 to apply and evaluate methods for data and sample collection of cord blood, maternal urine, breast milk, and maternal hair. The preanalytical conditions (the different steps from collection to storage) that are known to be responsible for more than 60% of laboratory errors ought to be considered.…”

mentioning

confidence: 99%

A Pilot Study of the ELFE Longitudinal Cohort: Feasibility and Preliminary Evaluation of Biological Collection

Oleko

Betsou

Sarter

et al. 2011

Biopreservation and Biobanking

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Etude Longitudinale Française depuis l'Enfance (ELFE) will be a national French cohort of 20,000 children followed from birth to adulthood. Biological samples will be taken at birth to evaluate the fetal exposition to several substances. A pilot study was carried out in October 2007 to test the preanalytical factors that affected sample quality. A variety of fractions were collected by the midwife after delivery from different blood collection tubes. Options in the collection process were 2 daily transports of samples, centralized and standardized processing methodology, and storage of multiple aliquots in liquid nitrogen or at -80°C. We analyzed preanalytical factors that could have affected coagulation and then soluble CD40 Ligand (sCD40L) as a quality control tool for serum quality. Cord blood and urine were collected from 82% and 84% of women, respectively, who agreed to be followed up in the ELFE project. The use of syringe was the main factor correlated with coagulation (relative risk: 2.79 [1.47; 5.31], P < 0.01). Maternity unit status was also associated with coagulation (RR: 1.48 [1.03; 2.13] in a private maternity unit vs. a public maternity) as well as time between collection and centrifugation (RR 1.03 [1; 1.07] when time between collection and centrifugation increases from 1 h). There were no extremely low sCD40L values indicating extreme exposures to room temperatures. This first evaluation study allowed us to stress the importance of carefully recording all potentially critical preanalytical variables that might be used at a large-scale level.

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“…There are certain pieces of information that are best collected via biological samples, such as blood samples, whereas other information (especially that related to geography and behavior) needs to be collected by carefully designed survey data collection tools (Emmett, 2009, Golding, 2009, Golding and Jones, 2009, Golding et al, 2009b, Jones and Golding, 2009). …”

Section: Methodological Considerations In the Collection Of Data And mentioning

confidence: 99%

Identifying important life stages for monitoring and assessing risks from exposures to environmental contaminants: Results of a World Health Organization review

Hubal¹,

Wet²,

Toit³

et al. 2014

Regulatory Toxicology and Pharmacology

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Choosing the types of biological sample to collect in longitudinal birth cohort studies

Abstract: There are a variety of biological samples that can be collected from participants in longitudinal studies. Here we outline those that are particularly useful in longitudinal birth cohort studies starting in pregnancy, and discuss their advantages and disadvantages.

Cited by 20 publications

References 76 publications

Sex Hormones, Gonadotropins, and Sex Hormone-binding Globulin in Infants Fed Breast Milk, Cow Milk Formula, or Soy Formula

Sex Hormones, Gonadotropins, and Sex Hormone-binding Globulin in Infants Fed Breast Milk, Cow Milk Formula, or Soy Formula

A Pilot Study of the ELFE Longitudinal Cohort: Feasibility and Preliminary Evaluation of Biological Collection

Identifying important life stages for monitoring and assessing risks from exposures to environmental contaminants: Results of a World Health Organization review

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