Choosing the appropriate pharmacotherapy for multidrug-resistant Gram positive infections

Fiore, Marco; Taccone, Fabio Silvio; Leone, Sebastiano

doi:10.1080/14656566.2018.1512584

Cited by 8 publications

(2 citation statements)

References 16 publications

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“…Moreover, there are insufficient data to support intravenous antibiotics[41-43]. A major concern of the antibiotic use in HS is the increasing of antimicrobial resistance[44,45]. Finally, a clinical monitoring and a dose adjustment in patients with liver disease can be required[46,47] in view of the fact that NAFLD remains the main source of ESLD in Western countries[1].…”

Section: Discussionmentioning

confidence: 99%

Nonalcoholic fatty liver disease prevalence in an Italian cohort of patients with hidradenitis suppurativa: A multi-center retrospective analysis

Damiani

Leone

Fajgenbaum

et al. 2019

WJH

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BACKGROUND Nonalcoholic fatty liver disease (NAFLD) includes two distinct conditions, with different histologic features and prognosis: non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH). Furthermore, NASH is the more aggressive necro-inflammatory form, which may accumulate fibrosis and result in End stage liver disease (ESLD). NAFLD is also linked to systemic inflammatory conditions such as psoriasis. NAFLD is currently the most common cause of ESLD in Western countries, becoming a serious public health concern. Hidradenitis suppurativa (HS) is a systemic inflammatory/autoinflammatory disease of the terminal follicular epithelium of the apocrine gland with a prevalence of 0.05% to 4.10%. Due to its systemic inflammatory behavior several comorbidities were recently associated, however liver ones were scarcely assessed. AIM To evaluate the prevalence and characteristics of NASH/NAFL in HS patients. METHODS This retrospective study is a sub-analysis of a larger study carried out in 4 Italian dermatological centers. In this cohort, there were 83 patients: 51 patients with HS only, 20 patients with HS/NAFL and 12 with HS/NASH. RESULTS Inflammatory comorbidities were present in 3.9% of HS only patients, 25% of HS/NAFL patients and 58.3% of HS/NASH patients ( P < 0.001). Similarly, mean Autoinflammatory Disease Damage Index (ADDI) was significantly higher among patients with HS/NASH (5.3 ± 2.2, P < 0.001) compared to patients with HS/NAFL or HS only (2.8 ± 1.6 and 2.6 ± 1.4 respectively). Furthermore, ADDI correlates with IHS4 in HS, HS/NAFL and HS/NASH. Diabetic patients have higher Hurley score than not diabetic ones. Ultrasound examination was significantly different in the three groups. CONCLUSION HS patients displayed a high prevalence of NASH/NAFLD and ultrasound examination should be particularly addressed to patients that display high ADDI scores.

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Section: Discussionmentioning

confidence: 99%

Nonalcoholic fatty liver disease prevalence in an Italian cohort of patients with hidradenitis suppurativa: A multi-center retrospective analysis

Damiani

Leone

Fajgenbaum

et al. 2019

WJH

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“…The second patient was treated by the ward of origin with piperacillin-tazobactam (TZP) in association with AMK; initially (September, 12) we treated the SS with ceftolozane-tazobactam (C/T) and metronidazole; ceftaroline, not active against VIM-producing S. marcescens , was added later (September, 24), as her condition deteriorated, for a suspected methicillin-resistant Staphylococcus aureus infection[10]. The duration of total antibiotic therapy was 14 d.…”

Section: Treatmentmentioning

confidence: 99%

First Italian outbreak of VIM-producingSerratia marcescensin an adult polyvalent intensive care unit, August-October 2018: A case report and literature review

Iovene¹,

Pota²,

Galdiero³

et al. 2019

WJCC

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BACKGROUNDCarbapenem-resistant Enterobacteriaceae has become a significant public health concern as hospital outbreaks are now being frequently reported and these organisms are becoming difficult to treat with the available antibiotics.CASE SUMMARYAn outbreak of VIM-producing Serratia marcescens occurred over a period of 11 wk (August, 1 to October, 18) in patients admitted to the adult polyvalent intensive care unit of the University of Campania “Luigi Vanvitelli” located in Naples. Four episodes occurred in three patients (two patients infected, and one patient colonized). All the strains revealed the production of VIM.CONCLUSIONAfter three decades of carbapenem antibiotics use, the emergence of carbapenem-resistance in Enterobacteriaceae has become a significant concern and a stricter control to preserve its clinical application is mandatory. This is, to our knowledge, the first outbreak of VIM-producing Serratia marcescens in Europe. Surveillance policies must be implemented to avoid future outbreaks.

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External to Internal Fixation Conversion Timing: Infectivologist’s Perspectives

Maccabruni

Mora

Pedrotti

et al. 2021

Hexapod External Fixator Systems

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Choosing the appropriate pharmacotherapy for multidrug-resistant Gram positive infections

Cited by 8 publications

References 16 publications

Nonalcoholic fatty liver disease prevalence in an Italian cohort of patients with hidradenitis suppurativa: A multi-center retrospective analysis

Nonalcoholic fatty liver disease prevalence in an Italian cohort of patients with hidradenitis suppurativa: A multi-center retrospective analysis

First Italian outbreak of VIM-producingSerratia marcescensin an adult polyvalent intensive care unit, August-October 2018: A case report and literature review

External to Internal Fixation Conversion Timing: Infectivologist’s Perspectives

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