Choosing patients over placebos: oral transitional therapy vs. IV-only therapy for bacteraemia and infective endocarditis

Challenging Dogma in the Treatment of Childhood Infections: Oral Antibiotics and Shorter Durations

“…Reliance on IV therapy for bacteremia and even endocarditis has also been challenged, with trials and large retrospective studies available to support similar efficacy outcomes in selected patients, with shorter hospitalization and fewer adverse events. 8 It should be noted that this evidence is emerging from studies undertaken in adults, with limited pediatric data published to date.…”

Epidemiology, Diagnosis, Treatment, and Prognosis of Infective Endocarditis

“…Despite recent advances, the IE outcome remains poor. More research is needed, particularly in uncommon subgroups such as children [14,15], pulmonary IE [16], multivalvular IE [17], patients with solid organ transplantation [18,19], bicuspid aortic valves [20], and those treated with oral therapy [21]. In addition, better prognostic markers [22,23], more specific imaging techniques [24], and improved surgical scores [25] that aid in clinical decision-making are required.…”