Multiple-choice questions (MCQs) are a common modality used in undergraduate, graduate, and postgraduate medical education for assessing learners' knowledge across a number of applications.Educators create MCQs to assess learners' understanding of concepts and preparedness for higher-stakes examinations (e.g., United States Medical Licensing Examinations, in-training examinations, shelf examinations, board certification). Education researchers may use MCQs to assess knowledge before and after an intervention to gauge the intervention's effectiveness. Creators of online resources, including both paid (e.g., Physician's Evaluation and Educational Review, RoshReview) and open-access (e.g., https:// www.aliem.com/), may use MCQs as both tools for teaching (i.e., test-enhanced learning) and for learners to self-identify knowledge gaps to refine studying. Finally, learners may create their own tests to apply the learning or to share with others. Data have demonstrated the value of using MCQs for both knowledge assessment and test-enhanced learning. 1,2 Multiple-choice questions also offer the benefits of being time-efficient and easy to score and may allow more objective scoring compared with other open-ended testing methods. However, faculty rarely receive training in how to create a high-quality MCQ. This can lead to poorly constructed MCQs, which can hinder the ability to assess learning and guide study efforts by learners. 3,4 Moreover, poorly designed MCQs can also impact the ability to assess knowledge attained from an education intervention when used for program evaluation and research reporting. Therefore, there is a need to better understand the key components of creating effective MCQs for novice and experienced MCQ developers alike.