Choose your leaving group: selective photodeprotection in a mixture of pHP-caged compounds by VIPER excitation

Abstract

Photocages are light-triggerable molecular moieties that can locally release a pre-determined leaving group (LG). Finding a suitable photocage for a particular application may be challenging, as the choice may be...

Biomolecular infrared spectroscopy: making time for dynamics

“…An evolution of the VIPER method, which uses the VIPER pulse to selectively excite different leaving groups within a molecule has also been demonstrated. 130 This brings further potential for probing biological systems by using VIPER to activate photocaged species which may then react or otherwise initiate intermolecular interactions.…”