Choose your cell model wisely: The in vitro nanoneurotoxicity of differentially coated iron oxide nanoparticles for neural cell labeling

Joris, Freya; Valdepérez, Daniel; Pelaz, Beatriz; Wang, Tianqiang; Doak, Shareen H.; Manshian, Bella B.; Soenen, Stefaan J.; Parak, Wolfgang J.; Smedt, Stefaan C. De; Raemdonck, Koen

doi:10.1016/j.actbio.2017.03.053

Cited by 13 publications

(13 citation statements)

References 81 publications

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“…Since the paramagnetic properties of small IONPs are similar to Gdbased contrast agents, these nanoparticles can be utilized as T 1 contrast agents because of small magnetic moment and low toxicity (Bao et al, 2018). It however has to be pointed out that also for IONPs toxic effects exist (Joris et al, 2017;Feng et al, 2018;Patil et al, 2018), though to a much lesser extent than for chelated Gd. Toxicity may depend on various physicochemical properties such as size, shape, structure, concentration, surface modification, and solubility (Vanhecke et al, 2017;Feng et al, 2018;Patil et al, 2018;Vakili-Ghartavol et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

The Effect of Surface Coating of Iron Oxide Nanoparticles on Magnetic Resonance Imaging Relaxivity

Ahmadpoor

Masood

Feliu

et al. 2021

Front. Nanotechnol.

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Iron oxide nanoparticles (IONPs) with acceptable biocompatibility and size-dependent magnetic properties can be used as efficient contrast agents in magnetic resonance imaging (MRI). Herein, we have investigated the impact of particle size and surface coating on the proton relaxivity of IONPs, as well as engineering of small IONPs' surface coating as a strategy for achieving gadolinium-free contrast agents. Accordingly, polymer coating using poly(isobutylene-alt-maleic anhydride) (PMA) with overcoating of the original ligands was applied for providing colloidal stability to originally oleic acid–capped IONPs in aqueous solution. In case of replacement of the original ligand shell, the polymer had been modified with dopamine. Furthermore, the colloidal stability of the polymer-coated IONPs was evaluated in NaCl and bovine serum albumin (BSA) solutions. The results indicate that the polymer-coated IONPs which involved replacement of the original ligands exhibited considerably better colloidal stability and higher proton relaxivity in comparison to polymer-coated IONPs with maintained ligand shell. The highest r2/r1 we obtained was around 300.

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Section: Introductionmentioning

confidence: 99%

The Effect of Surface Coating of Iron Oxide Nanoparticles on Magnetic Resonance Imaging Relaxivity

Ahmadpoor

Masood

Feliu

et al. 2021

Front. Nanotechnol.

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“…The marked structural and chemical flexibility of these materials allows for extensive biochemical and functional properties, such as site targeting, engineered drug release mechanisms, and physiological barrier specificity 3,6,7 . However, due to their size, nanomaterials have the potential to affect biological organisms on all levels, from the whole organism to cellular, sub-cellular, and macromolecular levels 4,8,9 . A variety of biological effects have been noted, including membrane disruption 10 , inflammatory effects 8,[11][12][13][14][15][16][17] , and cytotoxicity 8,12,14,15,[17][18][19] .…”

Section: Introductionmentioning

confidence: 99%

Augmentation of C17.2 Neural Stem Cell Differentiation via Uptake of Low Concentrations of ssDNA‐Wrapped Single‐Walled Carbon Nanotubes

et al. 2019

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Nanostructured biomaterials have been extensively explored in clinical imaging and in gene/drug delivery applications. However, limited studies have been performed that examine the influence that nanomaterials may have on cell behavior over long time scales at nonlethal concentrations. The study was designed to investigate whether carbon nanotubes are able to augment cell behavior at low concentrations. Single-walled carbon nanotubes were introduced to neural stem cells at different stages of differentiation at concentrations as low as 5 ng/mL. Results demonstrate that in this particular cell model, nanotube uptake is mediated by endocytosis.Differentiation is augmented, especially when nanotubes are introduced to cells in an actively dividing state. Significant increases in neuronal cell population were observed over the control specimens. While the mechanisms behind this observation are yet unknown, the study demonstrates that low concentrations of internalized nanomaterials can significantly alter the differentiation profile of a stem cell line.

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“…The use of nanotechnology in diagnostics but also in drug delivery and tissue engineering could significantly improve the treatment of patients with injured neuronal tissue [ 386 , 387 , 388 , 389 , 390 ]. Hence, IONP-labelling of stem cells or other cells, such as astrocytes and microglia can be used to track and monitor transplanted cells after implantation, e.g., by a noninvasive imaging modality such as MRI, magnetic particle imaging, positron emission tomography, and multiple photon microscopy [ 391 , 392 , 393 , 394 , 395 , 396 , 397 , 398 , 399 , 400 , 401 , 402 ]. Moreover, IONPs and IONP-loaded cells allow the delivery of therapeutic biomolecules, such as neurotrophic factors, drugs, proteins, DNA and siRNA by specific NP functionalization [ 403 , 404 , 405 , 406 , 407 ].…”

Section: Pns and Cns Regenerationmentioning

confidence: 99%

Iron Oxide Nanoparticles in Regenerative Medicine and Tissue Engineering

2021

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In recent years, many promising nanotechnological approaches to biomedical research have been developed in order to increase implementation of regenerative medicine and tissue engineering in clinical practice. In the meantime, the use of nanomaterials for the regeneration of diseased or injured tissues is considered advantageous in most areas of medicine. In particular, for the treatment of cardiovascular, osteochondral and neurological defects, but also for the recovery of functions of other organs such as kidney, liver, pancreas, bladder, urethra and for wound healing, nanomaterials are increasingly being developed that serve as scaffolds, mimic the extracellular matrix and promote adhesion or differentiation of cells. This review focuses on the latest developments in regenerative medicine, in which iron oxide nanoparticles (IONPs) play a crucial role for tissue engineering and cell therapy. IONPs are not only enabling the use of non-invasive observation methods to monitor the therapy, but can also accelerate and enhance regeneration, either thanks to their inherent magnetic properties or by functionalization with bioactive or therapeutic compounds, such as drugs, enzymes and growth factors. In addition, the presence of magnetic fields can direct IONP-labeled cells specifically to the site of action or induce cell differentiation into a specific cell type through mechanotransduction.

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Choose your cell model wisely: The in vitro nanoneurotoxicity of differentially coated iron oxide nanoparticles for neural cell labeling

Cited by 13 publications

References 81 publications

The Effect of Surface Coating of Iron Oxide Nanoparticles on Magnetic Resonance Imaging Relaxivity

The Effect of Surface Coating of Iron Oxide Nanoparticles on Magnetic Resonance Imaging Relaxivity

Augmentation of C17.2 Neural Stem Cell Differentiation via Uptake of Low Concentrations of ssDNA‐Wrapped Single‐Walled Carbon Nanotubes

Iron Oxide Nanoparticles in Regenerative Medicine and Tissue Engineering

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