Chonemorphine, stigmasterol, and ecdysterone: Steroids isolated through bioassay-directed plant screening programs

Shah, Virbala C.; D'sa, Adolf S.; Souza, N. J. De

doi:10.1016/0039-128x(89)90031-7

Cited by 9 publications

(2 citation statements)

References 10 publications

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“…6) as well as the tetrater- penoid crocetin dialdehyde [70] and the sterols {ergosterol endoperoxide (5α,8α-epidioxy-ergosta-6,22-dien-3β-ol) [30], 5α,8α-epidioxy-ergosta-6,9(11),22-trien-3β-ol [30], stigmasterol [16,71], and β-sitosterol [16,24,30]} were isolated from different tissues of P. barbatus distributed in India and China.…”

Section: Miscellaneous Constituentsmentioning

confidence: 99%

Plectranthus barbatus: A Review of Phytochemistry, Ethnobotanical Uses and Pharmacology – Part 1

Alasbahi

Melzig

2010

Planta Med

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Plectranthus L′ Herit., is a complex genus of the family Lamiaceae (Labiatae) that contains about 300 species distributed in tropical Africa, Asia and Australia [1]. Taxonomically the genera Coleus and Plectranthus are recombined by the Japanese authors to the genus Plectranthus [2]. One of the most important species of this genus is Plectranthus barbatus Andr., which is commonly referred to by a number of synonyms such as Plectranthus forskohlii Briq, Plectranthus forskalaei Willd., Plectranthus kilimandschari (Gürke) H. L. Maass., Plectranthus grandis (Cramer) R. H. Willemse, Coleus forskohlii Briq., Coleus kilimandschari Gürke ex Engl., Coleus coerulescens Gürke, Coleus comosus A. Rich., and Coleus barbatus (Andr.) Benth [1]. Plectranthus barbatus grows perennially over the tropical and subtropical regions of the Indian subcontinent and is cultivated commercially for its use in pickles. It is also distributed over parts of Pakistan, Sri Lanka, tropical East Africa, Asia (South of Arabian Peninsula, China) and Brazil [3-5]. P. barbatus is one of the most commonly used medicinal species of the genus Plectranthus. A diversity of traditional medicinal uses of P. barbatus in India (Hindu and Ayurvedic medicine), East and Central Africa, China, and Brazil have been reported. The majority of uses are for intestinal disturbance and liver fatigue, respiratory disorders, heart diseases and certain central nervous system disorders [1, 3, 4, 6, 7]. P. barbatus root extracts, such as the 50% ethanolic and methanolic extracts were therefore, in the middle of the 1970s, independently involved in screening programs for biological activities such as cardiovascular properties in the Central Drug Research Institute (CDRI), Lucknow, India, and by the group at Hoechst India Limited in Bombay, India. Reports from both research groups revealed the hypotensive and antispasmodic effects of the root extracts as well as the isolation of the major active principle which was named coleonol by CDRI [

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Section: Miscellaneous Constituentsmentioning

confidence: 99%

Plectranthus barbatus: A Review of Phytochemistry, Ethnobotanical Uses and Pharmacology – Part 1

Alasbahi

Melzig

2010

Planta Med

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“…Thus far, more than twenty compounds have been isolated from plants of the genus Chonemorpha , including alkaloids, lignans, triterpenoids, phenolic acids, and flavonoids [7–8] . These compounds show important pharmacological activities, such as clearing and activating channels and collaterals, the antiamoebic and antitrichomonad, [9–11] inhibiting pain, and treating hypotension in addition to promoting blood circulation, bone, and muscle growth [12] …”

Section: Introductionmentioning

confidence: 99%

Antioxidant Activities and Allelopathic Potential of Chonemorpha splendens Chun et Tsiang Stem Methanol Extract

Luo

Zhao

et al. 2022

Chemistry & Biodiversity

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Finding agriculturally active compounds from nature or finding active lead compounds from natural products, artificial synthesis and structural modification are the main ways to create new agrochemical. In order to explore the agricultural activities of Chonemorpha splendens Chun et Tsiang (C. splendens), an important medicinal plant, the antioxidant activities and allelopathic potential were investigated. C. splendens was extracted with methanol, then, C. splendens methanol extract (CSME) were extracted with petroleum ether, chloroform, ethyl acetate and butanol. Reducing activity, lipid peroxidation, and the scavenging abilities for DPPH⋅, O2−., HO⋅, and H2O2 were also measured and allelopathic potentials were evaluated by bioassay method. GC/MS analysis revealed that esters were the main component (66.34 %) of CSME, the total CSME flavonoid content was 313 mg g−1 (rutin equivalent). The chloroform phase of CSME was identified as stigmasterol by NMR for the first time. The DPPH⋅ scavenging rate of CSME was 87 %, with an IC50 value of 0.12±0.02 mg mL−1, which was significantly difference from the positive control, Trolox. Chloroform fraction showed the strongest inhibitory effect against Mimosa pudica (MP) seed germination at 1.0 mg mL−1 (100 % inhibition), which was better than that of the chemical herbicide paraquat. In the seed growth experiment, systematic EC50 and the principal component analysis (PCA) were used to assess the allelopathic potential of extracts. The systematic EC50 values of Crotalaria pallida Ait. (CP), Bidens pilosa L. (BP) were significantly greater than MP. MP, Oryza sativa L. (OS) and Lactuca satiua L., (LS) inhibited all parameters. Our results would provide an idea for controlling weeds through allelopathy from C. splendens to reduce dependency on synthetic herbicides.

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Chemistry and Bioactivity of Saponins from Some Sri Lankan Plants

Jayasinghe

Wannigama

Fujimoto

2000

Saponins in Food, Feedstuffs and Medicinal Plants

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Chonemorphine, stigmasterol, and ecdysterone: Steroids isolated through bioassay-directed plant screening programs

Cited by 9 publications

References 10 publications

Plectranthus barbatus: A Review of Phytochemistry, Ethnobotanical Uses and Pharmacology – Part 1

Plectranthus barbatus: A Review of Phytochemistry, Ethnobotanical Uses and Pharmacology – Part 1

Antioxidant Activities and Allelopathic Potential of Chonemorpha splendens Chun et Tsiang Stem Methanol Extract

Chemistry and Bioactivity of Saponins from Some Sri Lankan Plants

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