Chondrosarkom des Siebbeins und der Keilbeinhöhle

Abstract

Recent prognostic improvements of skull base chondrosarcomas by combination of skull base surgery and innovative radiation therapy are discussed and the literature is presented.

Sinonasal Chondrosarcoma, an Unusual Location

“…The main related series of this location is that of Knott et al [4] where 13 cases were described over a period of 25 years. Other studies report a few cases like Touati et al [5] with 2 cases, while Krömer et al [2] and Rowley et al [6] report one case in each study. The clinical presentation of CS depends primarily on the site affected and the extent of the tumour.…”

“…CSs mainly appear in long bones and in pelvic bones. Between 5 and 10% of tumours are located in the head and neck area [2] . It is a slow-growing tumour that preferentially affects males and the frequency peak is observed between 40 and 60 years of age [3] .…”

“…Conventional CS is the most common form and can be classified into 4 degrees of malignancy based on cell abundance, nuclear polymorphism and the mitotic rate. The other forms are clear cell CS, mesenchymal CS and undifferentiated CS [2] . The differential diagnosis of sinonasal CS includes chondroma, chordoma and chondromyxoid fibroma.…”

Schädelbasischondrosarkome

“…Dementsprechend beschränken sich die meisten Publikationen auf Fallberichte oder kleine Patientenkohorten. So sind im deutschsprachigen otorhinologischen Schrifttum in den letzten 25 Jahren nur 2 Fallberichte zum Schädelbasischondrosarkom erschienen [20,36]. Schwerdtfeger beschrieb 1911 erstmals ein Chondrosarkom in den Nasennebenhöhlen (zit.…”

Das Klarzellchondrosarkom des Nasenseptums

“…Neben knöchernen Destruktionen sind in der Computertomographie auch die für die klarzellige Chondrosarkomvariante typischen intratumoralen Verkalkungen sichtbar (Abb. 1), [16,20,31].…”