Chondrosarcoma of the jaw bones: a review of 224 cases reported to date and an analysis of prognostic factors

Souza, Lucas Lacerda de; Pontes, Flávia Sirotheau Corrêa; Fonseca, Felipe Paiva; Rezende, Diogo; Vasconcelos, Victor César Souza; Pontes, Hélder Antônio Rebelo

doi:10.1016/j.ijom.2018.11.006

Cited by 18 publications

(23 citation statements)

References 101 publications

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“…Chondrosarcoma (CHS) is a primary bony malignant tumor characterized by neoplastic cells producing hyaline cartilage [ 14 , 15 ]. Among all cases of CHS described in the literature, only 1% are referred to the jaws [ 16 ]; thus, it is considered a rare and poorly documented lesion [ 17 ]. This slow-growing lesion presents high local invasiveness and mild clinical presentation that often lead to a tardive diagnosis with huge tumors already at the first medical observation.…”

Section: Discussionmentioning

confidence: 99%

“…This slow-growing lesion presents high local invasiveness and mild clinical presentation that often lead to a tardive diagnosis with huge tumors already at the first medical observation. The most common symptoms are swelling of the involved area, pain, and facial asymmetry [ 17 ]. Prognosis of affected patients is defined by histological type (six different patterns have been described), tumor grade, recurrence, presence of metastasis (even if really rare), and quality of the surgical treatment [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…The most common symptoms are swelling of the involved area, pain, and facial asymmetry [ 17 ]. Prognosis of affected patients is defined by histological type (six different patterns have been described), tumor grade, recurrence, presence of metastasis (even if really rare), and quality of the surgical treatment [ 17 ]. Regarding treatment solutions, wide surgical resection of the tumor is considered the gold standard, since it is associated with the best prognosis [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

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Wide Anterior Maxillary Reconstruction with Equine Bone Xenograft: A Case Report of 24-Month Follow-Up

Cicco

Colella

Tartaro

et al. 2020

Case Reports in Surgery

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Introduction. Orofacial reconstruction plays an important role in the treatment of patients affected by oral and maxillofacial cancers. Improvements in technologies and studies of biomaterials have widely expanded surgical possibilities to achieve good functional and aesthetic outcomes. By the way, xenografting procedures gained great consensus in the last decades, because of their documented reliability and efficacy. We present a case of anterior maxillary chondrosarcoma (CHS) that has undergone surgical ablation followed by reconstruction with an equine-derived bone xenograft. Case Presentation. A 68-year-old woman affected by CHS of the premaxilla underwent surgical ablation involving the four incisors followed by reconstruction using an equine-derived bone substitute. Bony reconstruction was planned to achieve implant and dental prosthetic rehabilitation at a second surgical time. Primary surgery was carried out without complications. Good integration of the graft was confirmed by radiological examination. At 12-month follow-up, the patient refused the implant placement and spontaneously adopted a mobile prosthesis. One year later, plates and screws were removed, because of the exposure of a titanium plate. The graft was finally rejected within 3 weeks. Discussion. Nonantigenic equine-derived biomaterials have shown reliability and a good safety profile. In the presented case, implant insertion should have been performed 12 months after the primary surgery. During the follow-up, until dental mobile prosthesis was applied, clinical and instrumental examinations demonstrated a good integration of the graft. We suppose that a chronic inflammation of the mucosa led to the exposure of the plate, perhaps due to pressure, minimal movements, or imperfect fitting of the mobile prosthesis. Removal of fixation means was performed to prevent grafting failure, without success. On the other hand, missing load could induce the graft to act just like a prosthesis, without a real process of integration. Safety and reliability of equine-derived bone xenografts cannot be currently confirmed if not followed by implant insertion and dental rehabilitation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Wide Anterior Maxillary Reconstruction with Equine Bone Xenograft: A Case Report of 24-Month Follow-Up

Cicco

Colella

Tartaro

et al. 2020

Case Reports in Surgery

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“…This study followed the PRISMA Statement guidelines. 14 The methodology of this research has already been applied in other previous studies 12,13,15 and a new criterion of analysis has been used in the current study to analyze RISOC.…”

Section: Methodsmentioning

confidence: 99%

Oral radiation‐induced sarcomas: Systematic review

et al. 2020

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Background The aim of this study was to integrate the available data published on radiation‐induced sarcoma of the oral cavity into an analysis of its clinical features, treatment modalities and prognostic factors. Methods An electronic search was undertaken in September 2019. The eligibility criteria included publications that had enough clinical and histological information to confirm the diagnosis. Results Forty‐two publications with 122 radiation‐induced sarcoma of the oral cavities (RISOCs) were included. The mean latency period was 114 months and mean radiation total dose was 62.5 Gy. The tumors were more prevalent in males between 50 and 60 years old and the mandible was the most affected site. Osteosarcoma was the most prevalent histological type and patients were mostly treated with radical surgery. Conclusions RISOC showed a poor survival rate of 15.1% in 5‐year follow‐up. Gender and histological type were independently associated with survival.

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“…In the jaw bones, chondrosarcomas are exceedingly rare which might be influenced by their development mainly through intramembranous ossification. A larger meta-analysis reported maxillofacial chondrosarcomas to account for 3-4% of all chondrosarcomas although it is impossible to exclude chondroblastic osteosarcomas in all the studies considered that can closely mimic chondrosarcoma [10]. The maxilla and nasal septum are more frequently involved than the mandible (Fig.…”

Section: Malignant Maxillofacial Bone and Cartilage Tumoursmentioning

confidence: 99%

Molecular findings in maxillofacial bone tumours and its diagnostic value

et al. 2019

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According to the WHO, mesenchymal tumours of the maxillofacial bones are subdivided in benign and malignant maxillofacial bone and cartilage tumours, fibro-osseous and osteochondromatous lesions as well as giant cell lesions and bone cysts. The histology always needs to be evaluated considering also the clinical and radiological context which remains an important cornerstone in the classification of these lesions. Nevertheless, the diagnosis of maxillofacial bone tumours is often challenging for radiologists as well as pathologists, while an accurate diagnosis is essential for adequate clinical decision-making. The integration of new molecular markers in a multidisciplinary diagnostic approach may not only increase the diagnostic accuracy but potentially also identify new druggable targets for precision medicine. The current review provides an overview of the clinicopathological and molecular findings in maxillofacial bone tumours and discusses the diagnostic value of these genetic aberrations.

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Chondrosarcoma of the jaw bones: a review of 224 cases reported to date and an analysis of prognostic factors

Cited by 18 publications

References 101 publications

Wide Anterior Maxillary Reconstruction with Equine Bone Xenograft: A Case Report of 24-Month Follow-Up

Wide Anterior Maxillary Reconstruction with Equine Bone Xenograft: A Case Report of 24-Month Follow-Up

Oral radiation‐induced sarcomas: Systematic review

Molecular findings in maxillofacial bone tumours and its diagnostic value

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