Chondrosarcoma of the Chest Wall: Factors Affecting Survival

McAfee, Molly K.; Pairolero, Peter C.; Bergstralh, Erik J.; Piehler, Jeffrey M.; Unni, K. Krishnan; McLeod, Richard A.; Bernatz, Philip E.; Payne, W. Spencer

doi:10.1016/s0003-4975(10)60344-x

Cited by 144 publications

(103 citation statements)

References 16 publications

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“…The present case was a grade 3, considering its high cellularity and the predominance of the myxoid matrix, with only sparse foci of chondroid appearance. The rapid local recurrence and distant metastases seem to be in accordance with those reported for high-grade tumors (Bjornsson et al, 1998;McAfee et al, 1985).…”

Section: Discussionsupporting

confidence: 88%

Establishment and Characterization of a Continuous Human Chondrosarcoma Cell Line, ch-2879: Comparative Histologic and Genetic Studies with Its Tumor of Origin

Gil-Benso

López‐Ginés

Löpez‐Guerrero

et al. 2003

Laboratory Investigation

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SUMMARY:Chondrosarcomas are malignant cartilage-forming tumors that represent the second most common malignant solid tumor of bone. These biologically poorly understood neoplasms vary considerably in clinical presentation and biologic behavior. Chemotherapy and radiation therapy are generally ineffective. Here we describe the establishment and characterization of a new human chondrosarcoma cell line named ch-2879, and we compare the cell line with its tumor of origin. The cell line was established from a recurrent grade 3 chondrosarcoma of the chest wall and characterized by growth kinetics and morphologic studies. Immunocytochemistry and RT-PCR were performed to examine the expression of cartilage-specific phenotypes. Genetic characterization was performed using cytogenetics, fluorescence in situ hybridization, flow cytometry, and molecular techniques for analysis of the genes implicated in cell cycle control, amplification of MDM2, CDK4, and Cyclin D1, and mutations in the p53 gene. ch-2879 cells were subcultured for more than 80 passages. They expressed vimentin, HNK-1, HBA-71, Ki-67, cyclin D1, Fli-1, S-100, p21, p27, and p53 and were negative for cytokeratin, EMA, p14, p16, MDM2, Rb, and c-erb-b2 antigens. Cytogenetically the recurrent tumor showed a hyperhaploid karyotype with clonal numerical and structural abnormalities. The sole structural abnormality was a chromosome derivative of a t(1;21) translocation. The cell line at passage 3 showed two populations: the hyperhaploid and an exactly duplicated, hypotriploid population. After the 18th passage, only the hypotriploid population was present. The cells expressed collagen 2. Molecular comparison of the primary and recurrent tumor evidenced an in vivo molecular change consisting of a deletion of 9p21 genes in the recurrence, probably caused by a selection process. Because of its gene expression profile, including expression of genes implicated in chondrogenesis in uncoated plastic dishes, this cell line may prove useful for cellular and molecular studies as well as studies of chondrosarcoma characterization and treatment. (Lab Invest 2003, 83:877-887).

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Section: Discussionsupporting

confidence: 88%

Establishment and Characterization of a Continuous Human Chondrosarcoma Cell Line, ch-2879: Comparative Histologic and Genetic Studies with Its Tumor of Origin

Gil-Benso

López‐Ginés

Löpez‐Guerrero

et al. 2003

Laboratory Investigation

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“…Nevertheless, reaction or destruction of the periosteum might cause pain. McAfee et al [1] and Berquist et al [13] recommended the radical excision of all structures attached to the tumour such as lung, pericardium or thymus. In the study of King et al [7], the involvement of the viscera was additionally associated with worse oncological outcome with reduced survival.…”

Section: Discussionmentioning

confidence: 99%

“…Chest wall defects which are protected by the scapula and posterior muscle groups do not require reconstruction, while lateral chest wall and sternal defects have to be stabilised to protect the underlying viscera, to improve the respiratory mechanics and at least to improve the cosmetic result [1,3,8]. Nevertheless, wide margins are inevitable, and therefore resection has to be done without any compromise and reconstruction should be performed by a separate team of plastic surgeons if necessary.…”

Section: Discussionmentioning

confidence: 99%

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Surgical therapy of primary malignant bone tumours and soft tissue sarcomas of the chest wall: a two-institutional experience

Friesenbichler

Leithner

Maurer-Ertl

et al. 2014

International Orthopaedics (SICOT)

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“…[5][6][7][8][9][10] The prognosis is influenced by local recurrence, which occurs in 7% to 52% of patients. 8,11,12 In most cases, local recurrence is caused by an incomplete or a marginal surgical resection. 12,13 Thus, surgery must combine the oncologic need for a radical resection with regard for respiratory function and the mechanics of the chest itself.…”

mentioning

confidence: 99%

Ultrasonography Is Superior to Computed Tomography and Magnetic Resonance Imaging in Determining Superficial Resection Margins of Malignant Chest Wall Tumors

Briccoli

Galletti

Salone

et al. 2007

Journal of Ultrasound in Medicine

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Objective. The purpose of this study was to retrospectively analyze results obtained in 22 patients affected by malignant high-grade chest wall tumors evaluated preoperatively by ultrasonography as well as other imaging techniques. Methods. Twenty-two patients with chest wall high-grade sarcomas routinely underwent computed tomography, magnetic resonance imaging, total body scintigraphy, and ultrasonography. Ultrasonography was always performed by the same person using an ultrasonography system with a 5-to 13-MHz probe and with color Doppler evaluation of the lesion. Scans were done with the patient positioned as during surgery. Tumor lateral margins were identified, and a line was marked at 4 cm. In 8 patients with local recurrence, the presence of micronodules was also studied. Results of computed tomography, magnetic resonance imaging, and ultrasonography were compared with the surgical specimens. Results. Histologically, all surgical specimens excised according to ultrasonographic margins showed wide margins. Ultrasonography showed micronodules in 6 of 8 patients with local recurrence; histologically, they were all identified as sarcoma nodules. Ultrasonography failed in particular with cervical-mediastinal vessels. Conclusions. Our results confirm that ultrasonography is feasible and reliable in the study of superficial margins and for detection of micronodules of less than 0.5 cm in diameter.

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Chondrosarcoma of the Chest Wall: Factors Affecting Survival

Cited by 144 publications

References 16 publications

Establishment and Characterization of a Continuous Human Chondrosarcoma Cell Line, ch-2879: Comparative Histologic and Genetic Studies with Its Tumor of Origin

Establishment and Characterization of a Continuous Human Chondrosarcoma Cell Line, ch-2879: Comparative Histologic and Genetic Studies with Its Tumor of Origin

Surgical therapy of primary malignant bone tumours and soft tissue sarcomas of the chest wall: a two-institutional experience

Ultrasonography Is Superior to Computed Tomography and Magnetic Resonance Imaging in Determining Superficial Resection Margins of Malignant Chest Wall Tumors

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