Chondrosarcoma of maxilla

Karadwal, Asha; Chatterjee, Shailja

doi:10.4103/jomfp.jomfp_169_15

Cited by 6 publications

(7 citation statements)

References 10 publications

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“…Higher tumor grade is associated with poorer outcomes. Studies have demonstrated 5‐year survival rates of grade 1, grade 2, and grade 3 chondrosarcomas at all sites to be ≈90%, 81%, and 43%, respectively, corroborating the importance of grade demonstrated in our study 7,33–35 . While it did not reach statistical significance, larger tumor size trended toward incremental increased mortality risk.…”

Section: Discussionsupporting

confidence: 87%

“…Studies have demonstrated 5-year survival rates of grade 1, grade 2, and grade 3 chondrosarcomas at all sites to be ≈90%, 81%, and 43%, respectively, corroborating the importance of grade demonstrated in our study. 7,[33][34][35] While it did not reach statistical significance, larger tumor size trended toward incremental increased mortality risk. Other studies have found increased tumor volume to be associated with higher risk of treatment failure.…”

Section: Pooled Site Analysismentioning

confidence: 82%

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Determinants of survival in sinonasal and skull base chondrosarcoma: An analysis of the National Cancer Database

Rimmer

Mace

Andersen

et al. 2021

Int Forum Allergy Rhinol

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Background Chondrosarcomas are rare, malignant chondroid tumors that can occur in the sinonasal and skull base regions. Surgery is a mainstay of treatment, but complete resection can be challenging because of the close proximity of critical neurovascular structures. Because of their rarity and relatively indolent nature, optimal treatment regimens are not established. Our objective was to assess determinants of survival for sinonasal and skull base chondrosarcomas utilizing the National Cancer Database (NCDB). Methods The NCDB (2004–2017) was queried for cases of sinonasal and skull base chondrosarcoma. Multivariate hazard regression modeling was used to identify significant predictors of 60‐month and 120‐month overall survival (OS). Results Seven hundred thirty‐six cases met inclusion criteria. OS for all treatment types was 84.7% [SE±0.02] at 60 months and 75.6% [SE±0.02] at 120 months. Surgery with or without adjuvant treatment was found to associate with highest OS at 60 and 120 months. For patients receiving adjuvant radiation during treatment, proton therapy had significantly better OS at 60 months (95.4% [SE±0.03] vs 82.3% [SE±0.03], ‐2 = 5.27; p = 0.02) and 120 months (85.1% [SE±0.08] vs 72.8% [SE±0.05], ‐2 = 4.11; p = 0.04) compared with conventional external beam. After adjustment for primary site, multivariate Cox regression modeling (n = 561) identified cofactors significantly associated with variation in mortality risk at 60 and 120 months, including age, Charlson‐Deyo total score ≥ 3, insurance provision status, and tumor grade. Conclusions Sinonasal and skull base chondrosarcoma are primarily treated with surgery with favorable OS. Adjuvant treatment may be required and proton radiation was associated with improved 60‐month and 120‐month survival compared with conventional radiation.

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Section: Discussionsupporting

confidence: 87%

Section: Pooled Site Analysismentioning

confidence: 82%

Determinants of survival in sinonasal and skull base chondrosarcoma: An analysis of the National Cancer Database

Rimmer

Mace

Andersen

et al. 2021

Int Forum Allergy Rhinol

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“…In diseased states including cancer, however, NO production is often dysregulated. Some studies report that NO production increases during cancer progression 18,35,36 , while others report the opposite 24,37,38 . Thus, too much or too little NO might equally contribute to disease pathogenesis 39,40 .…”

Section: Introductionmentioning

confidence: 99%

Reduced Basal Nitric Oxide Production Induces Precancerous Mammary Lesions via ERBB2 and TGFβ

Ren

Zheng

Bommarito

et al. 2019

Sci Rep

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One third of newly diagnosed breast cancers in the US are early-stage lesions. The etiological understanding and treatment of these lesions have become major clinical challenges. Because breast cancer risk factors are often linked to aberrant nitric oxide (NO) production, we hypothesized that abnormal NO levels might contribute to the formation of early-stage breast lesions. We recently reported that the basal level of NO in the normal breast epithelia plays crucial roles in tissue homeostasis, whereas its reduction contributes to the malignant phenotype of cancer cells. Here, we show that the basal level of NO in breast cells plummets during cancer progression due to reduction of the NO synthase cofactor, BH 4 , under oxidative stress. Importantly, pharmacological deprivation of NO in prepubertal to pubertal animals stiffens the extracellular matrix and induces precancerous lesions in the mammary tissues. These lesions overexpress a fibrogenic cytokine, TGFβ, and an oncogene, ERBB2, accompanied by the occurrence of senescence and stem cell-like phenotype. Consistently, normalization of NO levels in precancerous and cancerous breast cells downmodulates TGFβ and ERBB2 and ameliorates their proliferative phenotype. This study sheds new light on the etiological basis of precancerous breast lesions and their potential prevention by manipulating the basal NO level.

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“…3,6,7,11 Two cases were mesenchymal chondrosarcoma (14%), and the dedifferentiated subtype accounted for 1 case (7%). 5,8,10 Two cases did not report the subtype. 4,9 Seven cases (50%) invaded the orbit via the medial wall.…”

Section: Discussionmentioning

confidence: 98%

“…Of these, few were sinonasal in origin. [3][4][5][6][7][8][9][10][11][12][13][14] The most common presenting symptoms reported were proptosis, (n = 7, 50%) and painless loss of vision (n = 6, 43%). 3,[6][7][8][11][12][13][14] Facial swelling was described by 2 patients, and eye pain and diplopia by 1 patient each.…”

Section: Discussionmentioning

confidence: 99%

Sinonasal Chondrosarcoma With Unusual Orbital Invasion

Pietris,

Tong,

Valentine

et al. 2024

Ophthalmic Plastic &Amp; Reconstructive Surgery

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A case is presented of a 43-year-old male with a chronic history of progressive nasal obstruction and epiphora. MRI confirmed a heterogeneous mass involving the middle and superior turbinates with T2 hyperintense and calcified components, with extension into the inferomedial orbit. Tissue biopsy revealed a grade 2 chondrosarcoma of the conventional subtype. Endonasal wide local resection of the lesion was performed with clear margins. The patient had no functional sequelae and will undergo routine surveillance.

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Chondrosarcoma of maxilla

Cited by 6 publications

References 10 publications

Determinants of survival in sinonasal and skull base chondrosarcoma: An analysis of the National Cancer Database

Determinants of survival in sinonasal and skull base chondrosarcoma: An analysis of the National Cancer Database

Reduced Basal Nitric Oxide Production Induces Precancerous Mammary Lesions via ERBB2 and TGFβ

Sinonasal Chondrosarcoma With Unusual Orbital Invasion

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