Chondroma of the dural convexity: A case report and literature review

Abstract

Chondromas are unusual tumors that arise from the base of the skull and have a predilection for the spheno-ethmoidal region. Chondromas represent less than 0.5% of all intracranial tumors. In rare instances, these tumors originate from the dura mater of the convexity. Fewer than 30 cases of dural chondromas arising from the convexity or the falx are reported in the literature. In this study, we describe a new case of convexity chondroma. We discuss the radiological and histological features of this case and also review the literature.

Intradural chondroma in the cervical spine: case report

“…By comparison, about 20 cases of intracranial dural chondromas, arising from the convexity or the falx cerebri, have been reported in the literature. 1 Although various hypotheses regarding the origin of intracranial chondromas have been presented, the pathogenesis of the chondromas re-mains controversial. It has been suggested that intracranial chondromas develop from heterotopic chondrocytes, 15 are secondary to metaplasia of meningeal fibroblasts or perivascular mesenchymal tissues, 2,5 or are secondary to the cartilaginous activation of fibroblasts by trauma or inflammation.…”

“…16 Meningeal chondromas are also rare and have been reported only as intracranial tumors. Although 20 cases of chondromas originating at the convexity of the dura mater have been described, 1 to the best of our knowledge, there has been no report of a meningeal chondroma located in the spine. The aim of our case report was to describe a case of intradural chondroma located in the cervical spine.…”

Primary spinal extraosseous cervical chondroma in an adult

“…[12,18] Although not pathognomonic, well-circumscribed solitary lesions with stippled calcification, a characteristic pattern of ring-like mild peripheral enhancement with central nonenhancing area; heterogeneously hyperintense appearance on T2-weighted imaging; absence of dural tail, hemorrhage, or cystic areas; and lack of tumor blush on angiography should suggest the radiological diagnosis of a chondroma. [15] Immunostaining reveals S100 positivity and absence of epithelial markers. [20] Histologically, the chondroma has a well-differentiated cartilaginous tissue surrounded by a delicate fibrous connective tissue capsule.…”

“…[1,19] The differential diagnosis includes a mesenchymal chondrosarcoma, meningioma, schwannoma, hemangiopericytoma, solitary fibrous tumor, Ewing's sarcoma, and metastatic tumor. [15] The primary microscopic differential diagnosis is a well-differentiated chondrosarcoma. Bland chondrocytes with no evidence of multinucleation, mitotic activity, or pleomorphism are evident among copious chondroid matrices.…”

A rare case of chondroma of falx cerebri

“…Numerous chondrocytes without nuclear atypia and mitotic active events are distributed in the rich cartilage matrix. Irregularly shaped calcifications and cystic areas have generally been found (2,4). The postoperative pathological examination of our case is consistent with these pathological features that determine the diagnosis of chondroma.Neuroimaging is the main method to discover chondroma of dural convexity and falx.…”