2005
DOI: 10.1002/art.20867
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Chondroitins 4 and 6 sulfate in osteoarthritis of the knee: A randomized, controlled trial

Abstract: Objective. To determine whether chondroitin sulfate (CS) is effective in inhibiting cartilage loss in knee osteoarthritis (OA).Methods. In this randomized, double-blind, placebo-controlled trial, 300 patients with knee OA were recruited from an outpatient clinic, from private practices, and through advertisements. Study patients were randomly assigned to receive either 800 mg CS or placebo once daily for 2 years. The primary outcome was joint space loss over 2 years as assessed by a posteroanterior radiograph … Show more

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Cited by 248 publications
(206 citation statements)
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“…[4][5][6][7][28][29][30][31] Recently, various biomarkers have been developed to detect the articular alterations in OA, and accumulating evidence suggests that there are associations with changes in ECM protein components in the cartilage and synovium as disease progresses in knee OA. 45,46) Finding the level of COMP in serum allows defining the degree of cartilage damage in OA 47,48) and observing effectiveness of the treatment.…”
Section: )mentioning
confidence: 99%
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“…[4][5][6][7][28][29][30][31] Recently, various biomarkers have been developed to detect the articular alterations in OA, and accumulating evidence suggests that there are associations with changes in ECM protein components in the cartilage and synovium as disease progresses in knee OA. 45,46) Finding the level of COMP in serum allows defining the degree of cartilage damage in OA 47,48) and observing effectiveness of the treatment.…”
Section: )mentioning
confidence: 99%
“…Only a few medications have been recognized by clinical trials as potentially influencing the course of OA beneficially. These include chondroitin sulfate (CS), [4][5][6][7] glucosamine, [8][9][10] diacerein, 11) doxycycline (an antibiotic belonging to the tetracycline family), 12) cyclooxygenase/5-lipoxygenase inhibitors, 13) and intra-articular injections of hyaluronic acid (HA). These approaches, however, have frequently produced insufficient benefit and excess risk of adverse effects.…”
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confidence: 99%
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“…В другой части исследований был проанализирован структурно-модифицирующий эффект ХС у больных с остеоартрозом коленных суставов. В двухгодичном двойном слепом ран-домизированном исследовании с оценкой динамики суже-ния суставной щели у 300 пациентов с гонартрозом, при-нимавших ХС в суточной дозе 800 мг или плацебо (по 150 больных в каждой группе), отмечено, что в группе ХС наблюдалось значимое замедление прогрессирования гонартроза: ширина суставной щели (как минимальная, так и средняя) в конце исследования статистически не отлича-лась от исходной величины в отличие от группы плацебо [39]. В одном из недавно завершенных исследований с участием 600 пациентов с манифестным остеоартрозом коленных суставов, которые в течение 2 лет получали ком-бинированную терапию глюкозамином и ХС, структурно-модифицирующий эффект оценивался с помощью МРТ.…”
Section: ключевые слова: дорсалгия спондилоартроз структурно-модифициunclassified