Chondroitin sulphate-based 3D scaffolds containing MWCNTs for nervous tissue repair

Serrano, María Concepción; Nardecchia, Stefania; García-Rama, Concepción; Ferrer, M. Luisa; Collazos‐Castro, Jorge E.; Monte, Francisco del; Gutiérrez, Marı́a C.

doi:10.1016/j.biomaterials.2013.11.017

Cited by 56 publications

(31 citation statements)

References 49 publications

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“…CS has been applied in cartilage regeneration, bone regeneration, skin regeneration or neuronal regeneration [14]. Recently, 3D nanocomposites composed of chondroitin sulphate and multi-walled carbon nanotubes (MWCNTs) for nervous tissue repair have been described [15]. …”

Section: Introductionmentioning

confidence: 99%

Green Synthesis of Hierarchically Structured Silver-Polymer Nanocomposites with Antibacterial Activity

et al. 2016

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The in situ formation of silver nanoparticles (AgNPs) aided by chondroitin sulfate and the preparation of a hierarchically structured silver-polymer nanocomposite with antimicrobial activity is shown. Green synthesis of AgNPs is carried out by thermal treatment (80 and 90 °C) or UV irradiation of a chondroitin sulfate solution containing AgNO3 without using any further reducing agents or stabilizers. Best control of the AgNPs size and polydispersity was achieved by UV irradiation. The ice-segregation-induced self-assembly (ISISA) process, in which the polymer solution containing the AgNPs is frozen unidirectionally, and successively freeze-drying were employed to produce the chondroitin sulfate 3D scaffolds. The scaffolds were further crosslinked with hexamethylene diisocyanate vapors to avoid water solubility of the 3D structures in aqueous environments. The antimicrobial activity of the scaffolds was tested against Escherichia coli. The minimum inhibitory concentration (MIC) found for AgNPs-CS (chondroitin sulfate) scaffolds was ca. 6 ppm.

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Section: Introductionmentioning

confidence: 99%

Green Synthesis of Hierarchically Structured Silver-Polymer Nanocomposites with Antibacterial Activity

et al. 2016

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“…MWCNT/CS scaffolds were prepared by using the ISISA technique as previously described [52]. Briefly, CS solutions were made by dissolving CS in deionized water.…”

Section: Methodsmentioning

confidence: 99%

Ice as a Green-Structure-Directing Agent in the Synthesis of Macroporous MWCNTs and Chondroitin Sulphate Composites

et al. 2017

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The incorporation of multi-walled carbon nanotubes (MWCNTs) into chondroitin sulphate-based scaffolds and the effect on the structural, mechanical, conductive, and thermal properties of the resulting scaffolds is investigated. Three-dimensional hierarchical materials are prepared upon the application of the ice segregation-induced self-assembly (ISISA) process. The use of ice as structure-directing agents avoids chemicals typically used for this purpose (e.g., surfactants, block copolymers, etc.), hence, emphasising the green features of this soft-templating approach. We determine the critical parameters that control the morphology of the scaffolds formed upon ice-templating (i.e., MWCNTs type, freezing conditions, polymer and MWCNT concentration). MWCNTs are surface functionalized by acidic treatment. MWCNT functionalization is characterized by Raman, Fourier transfer infrared (FTIR) and X-ray Photoelectron (XPS) spectroscopies. Scanning electron microscopy (SEM) analysis and porosity studies reveal that MWCNT content modifies the morphology of the macroporous structure, which decreases by increasing MWCNT concentration. Differences in scaffold morphology should be translated into their conductivity and mechanical properties. As a general trend, the Young’s modulus and the electrical conductivity of the scaffolds increase with the MWCNT content. Preliminary biocompatibility tests with human osteoblast-like cells also reveal the capability of these structures to support cell growth.

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“…In this research, a great number of neuron cells attached, for up to 20 days, on the viable networks that were supplied by the 3D porous scaffolds. The result suggested that the neural‐enriched networks showed calcium dynamics and active mitochondria . When these scaffolds are implanted in the acute phase after injury, the 3D structure of the scaffolds have more advantages in the enhancement of neural network formation compared with the 2D scaffolds, and CNTs are a type of suitable candidates in neural tissue devices.…”

Section: Cnms Used In Tissue Engineeringmentioning

confidence: 99%

The applications of conductive nanomaterials in the biomedical field

Zhao

Sun

et al. 2015

J Biomedical Materials Res

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Chondroitin sulphate-based 3D scaffolds containing MWCNTs for nervous tissue repair

Cited by 56 publications

References 49 publications

Green Synthesis of Hierarchically Structured Silver-Polymer Nanocomposites with Antibacterial Activity

Green Synthesis of Hierarchically Structured Silver-Polymer Nanocomposites with Antibacterial Activity

Ice as a Green-Structure-Directing Agent in the Synthesis of Macroporous MWCNTs and Chondroitin Sulphate Composites

The applications of conductive nanomaterials in the biomedical field

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