Osteoarthritis is the most common form of arthritis observed in the world. It is mainly defined as a process of repairing the joint, developed against the degeneration and destruction thereof, which cause various biochemical and morphological changes in the joint capsule and the synovial membrane. It is a multifactorial disease with several factors that can predispose, thus affecting any joint. It is the most common articular affection in domestic animals. The symptoms are caused by changes in the subchondral bone and loss of cartilage. Medium and large animals are the most affected, developing more severe clinical signs or initiating the degenerative process early, although animals of all sizes, sexes and breeds of dogs and cats can be affected by the disease. The affected animals present lameness, reluctance to move after rest and difficulty performing certain activities, these being the most common early signs. Although it is a disease that is characterized as noninflammatory, it exhibits a degree of inflammation that is very important in its pathogenesis. Considering that degenerative joint injuries of OA are irreversible, the goal of treatment is to alleviate discomfort, prevent or delay future degenerative changes, and try to restore function to the affected limb. The treatment should be done with pharmacological and non-pharmacological methods. The new approaches aim to prevent and delay the evolution of the disease, reversing the process of alteration of articular cartilage.