Chondroitin/dermatan sulfate purified from corb (Sciaena umbra) skin and bone: In vivo assessment of anticoagulant activity

Bougatef, Hajer; Ghlissi, Zohra; Kallel, Rim; Amor, Ikram Ben; Boudawara, T.; Gargouri, Jalel; Sahnoun, Zouheir; Volpi, Nicola; Sila, Assaâd; Bougatef, Ali

doi:10.1016/j.ijbiomac.2020.07.096

Cited by 12 publications

(9 citation statements)

References 31 publications

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“…Polysaccharides with strong anticoagulant activity have been obtained from marine vertebrates, , marine invertebrates, and marine plants. , The most common types of these polysaccharides are sulfated fucoidans (SFs), sulfated galactans (SGs), and the GAGs of marine invertebrates like fucosylated chondroitin sulfate (FucCS) and ascidian dermatan sulfate . Bougatef et al focused on the extraction of natural polysaccharides with anticoagulant activity from the skin and bones of marine vertebrates. ,,, These natural polysaccharides are mainly composed of chondroitin sulfate (CS) and dermatan sulfate (DS), which are extracted from the bones and skin of marine fish. The results indicate that CS and DS purified from fish bones have anticoagulant potential.…”

Section: Natural Anticoagulant Macromolecules: Peptides and Polysacch...mentioning

confidence: 99%

“…On the other hand, fish processing waste is a promising source for the separation and purification of CS, which has potential utilization value . Therefore, polysaccharides extracted from marine vertebrates could provide a promising source for future applications. ,,, With availability due to the high production in fisheries and aquaculture, in addition to natural polysaccharides that can be extracted from fish skin and bones as anticoagulant substances, the fish viscera also contain GAGs as natural anticoagulant macromolecules. Researchers have extracted and characterized the GAGs from the viscera of Nile tilapia, which mainly containing CS, DS, and heparan sulfate (HS), and these GAGs showed promising anticoagulant activity .…”

Section: Natural Anticoagulant Macromolecules: Peptides and Polysacch...mentioning

confidence: 99%

“…125 Bougatef et al focused on the extraction of natural polysaccharides with anticoagulant activity from the skin and bones of marine vertebrates. 49,55,57,126 These natural polysaccharides are mainly composed of chondroitin sulfate (CS) and dermatan sulfate (DS), which are extracted from the bones and skin of marine fish. The results indicate that CS and DS purified from fish bones have anticoagulant potential.…”

Section: Natural Anticoagulant Macromolecules: Peptides and Polysacch...mentioning

confidence: 99%

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Anticoagulant Macromolecules

et al. 2023

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Anticoagulant macromolecules have gained widespread use in the clinical treatment of cardiovascular diseases, blood-contacting or implantable materials, and medical devices due to their excellent anticoagulant properties. Inspired by the molecular characteristics of physiological anticoagulants that play a vital role in normal human coagulation and anticoagulation mechanisms, diverse anticoagulant macromolecules with special molecular structures and functional groups have been developed, where they can be systematically applied to the biomedical field. In this Perspective, the history and the recent progress of synthetic methods for anticoagulant macromolecules obtained by purification of natural products, semisynthetic methods, and synthetic methods are discussed from the aspect of molecular design. The critical application and immense development potential of these anticoagulant macromolecules in the field of clinical treatment and biomedicine is proposed.

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Section: Natural Anticoagulant Macromolecules: Peptides and Polysacch...mentioning

confidence: 99%

Section: Natural Anticoagulant Macromolecules: Peptides and Polysacch...mentioning

confidence: 99%

Section: Natural Anticoagulant Macromolecules: Peptides and Polysacch...mentioning

confidence: 99%

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Anticoagulant Macromolecules

et al. 2023

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“…In addition to dermatan sulfate and chondroitin sulfate alone demonstrating various extend of anticoagulant activities ( Table 1 ), a mixture of both chondroitin and dermatan sulfates at specific ratios have also been reported. The mixture of chondroitin and dermatan sulfates isolated from both the skin and bones of corb ( Sciaena umbra ) were evaluated in vitro using APTT, TT, and PT, and demonstrated that both skin and bone extract could prolong the APTT by 1.59 and 1.48-fold, respectively [ 57 ]. More recently, it was validated that a mixture of chondroitin and dermatan sulfate isolated from the skin of corb ( Sciaena umbra ) was in a 1 to 3 ratio, and that it has a remarkably high anticoagulant effect, while with 1000 µg/mL of concentration, it could significantly prolong the clotting time by 2.48-fold [ 58 ].…”

Section: Sulfated Polysaccharidesmentioning

confidence: 99%

Marine Biological Macromolecules and Chemically Modified Macromolecules; Potential Anticoagulants

et al. 2022

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Coagulation is a potential defense mechanism that involves activating a series of zymogens to convert soluble fibrinogen to insoluble fibrin clots to prevent bleeding and hemorrhagic complications. To prevent the extra formation and diffusion of clots, the counterbalance inhibitory mechanism is activated at levels of the coagulation pathway. Contrariwise, this system can evade normal control due to either inherited or acquired defects or aging which leads to unusual clots formation. The abnormal formations and deposition of excess fibrin trigger serious arterial and cardiovascular diseases. Although heparin and heparin-based anticoagulants are a widely prescribed class of anticoagulants, the clinical use of heparin has limitations due to the unpredictable anticoagulation, risk of bleeding, and other complications. Hence, significant interest has been established over the years to investigate alternative therapeutic anticoagulants from natural sources, especially from marine sources with good safety and potency due to their unique chemical structure and biological activity. This review summarizes the coagulation cascade and potential macromolecular anticoagulants derived from marine flora and fauna.

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“…In a subsequent in vivo study carried out on rats to assess the anticoagulant activity of both, it was shown that the administration of CBG and CSG at 25 and 75 mg/kg of body weight could increase the aPTT and TT values. However, the PT prolongation that was reported by in vitro studies could not be observed in the in vivo model [ 58 ].…”

Section: Marine Antithromboticsmentioning

confidence: 99%

Marine Antithrombotics

Dwivedi

Pomin

2020

Marine Drugs

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Thrombosis remains a prime reason of mortality worldwide. With the available antithrombotic drugs, bleeding remains the major downside of current treatments. This raises a clinical concern for all patients undergoing antithrombotic therapy. Novel antithrombotics from marine sources offer a promising therapeutic alternative to this pathology. However, for any potential new molecule to be introduced as a real alternative to existing drugs, the exhibition of comparable anticoagulant potential with minimal off-target effects must be achieved. The relevance of marine antithrombotics, particularly sulfated polysaccharides, is largely due to their unique mechanisms of action and lack of bleeding. There have been many investigations in the field and, in recent years, results have confirmed the role of potential marine molecules as alternative antithrombotics. Nonetheless, further clinical studies are required. This review covers the core of the data available so far regarding the science of marine molecules with potential medical applications to treat thrombosis. After a general discussion about the major biochemical steps involved in this pathology, we discuss the key structural and biomedical aspects of marine molecules of both low and high molecular weight endowed with antithrombotic/anticoagulant properties.

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Chondroitin/dermatan sulfate purified from corb (Sciaena umbra) skin and bone: In vivo assessment of anticoagulant activity

Cited by 12 publications

References 31 publications

Anticoagulant Macromolecules

Anticoagulant Macromolecules

Marine Biological Macromolecules and Chemically Modified Macromolecules; Potential Anticoagulants

Marine Antithrombotics

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