Chondrogenic effect of the perichondrium graft on the internal derangement and osteoarthritis of the temporomandibular joint of the rabbit

Filinte, Gaye Taylan; Akan, Mi̇that; Bilgiç, İlker Mehmet; Karaca, Mustafa; Aköz, Tayfun

doi:10.1016/j.jcms.2010.09.002

Cited by 6 publications

(2 citation statements)

References 28 publications

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“…Nevertheless, 60-day combined CS+G treatment in female rats subjected to tibial epiphyseal degeneration by ovariectomy resulted in marked chondrocyte proliferation and significant longitudinal bone growth [50]. In the TMJ, however, fibrocartilage may behave similarly to the perichondrium by becoming a source of mesenchymal cells that are precursors of new chondrocytes [51]. Therefore, it can be suggested that the effect of CS+G associated with the characteristics of fibrocartilage may have promoted the regression of the TMJ degenerative process observed in the present study.…”

Section: Discussionmentioning

confidence: 99%

Reduction of osteoarthritis severity in the temporomandibular joint of rabbits treated with chondroitin sulfate and glucosamine

et al. 2020

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Osteoarthritis is a degenerative disease that causes substantial changes in joint tissues, such as cartilage degeneration and subchondral bone sclerosis. Chondroitin sulfate and glucosamine are commonly used products for the symptomatic treatment of osteoarthritis. The aim of the present study was to investigate the effects of these products when used as structure-modifying drugs on the progression of osteoarthritis in the rabbit temporomandibular joint. Thirty-six New Zealand rabbits were divided into 3 groups (n = 12/group): control (no disease); osteoarthritis (disease induction); and treatment (disease induction and administration of chondroitin sulfate and glucosamine). Osteoarthritis was induced by intra-articular injection of monosodium iodoacetate. Animals were killed at 30 and 90 days after initiation of therapy. The treatment was effective in reducing disease severity, with late effects and changes in the concentration of glycosaminoglycans in the articular disc. The results indicate that chondroitin sulfate and glucosamine may have a structure-modifying effect on the tissues of rabbit temporomandibular joints altered by osteoarthritis. OPEN ACCESSCitation: Artuzi FE, Puricelli E, Baraldi CE, Quevedo AS, Ponzoni D (2020) Reduction of osteoarthritis severity in the temporomandibular joint of rabbits treated with chondroitin sulfate and glucosamine. PLoS ONE 15(4): e0231734. https://doi.org/ 10.

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Section: Discussionmentioning

confidence: 99%

Reduction of osteoarthritis severity in the temporomandibular joint of rabbits treated with chondroitin sulfate and glucosamine

et al. 2020

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“…Different treatment approaches have been described for TMJ dysfunction in literature. Taylan Filinte et al 17 reported that perichondrial grafts contributed to the treatment of osteoarthritis in a rabbit TMJ model, while Takafuji et al, 6 after inducing osteoarthritis in a rabbit model, reported the positive contributions of fibroblast growth factor 2 to treatment. In their study comparing hyaluronic acid and PRP for the treatment of TMJ osteoarthritis, Hegab et al 7 reported a higher level of efficacy with PRP.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Platelet-Rich Plasma on the Temporomandibular Joint After Radiotherapy in Rabbits

Kılıç

Yazici

et al. 2019

Ann Otol Rhinol Laryngol

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Objectives: Platelet-rich plasma (PRP) was administered into the temporomandibular joint (TMJ) space, which had been exposed to radiotherapy (RT), in an attempt to prevent and/or treat the late-term complications associated with RT when used for the treatment of head and neck cancers (nasopharyngeal cancer in particular) on the musculoskeletal system. Methods: A total of 13 adult male New Zealand ( Oryctolagus cuniculus) rabbits were used in the study. The animals were classified into 3 groups: 6 in the RT group, 6 in the RT+PRP group, and 1 in the control group (exposed to neither). The TMJ space of each rabbit was exposed to 2240 cGy external RT in total, and PRP was administered into the TMJ space 1 month later. The joints were surgically removed 1 month later and examined histopathologically. Results: In the group given RT+PRP, the level of inflammation, amount of muscle fibrosis, vascular wall fibrosis, synovial membrane and condyle cartilage thickness, temporal extrabone fibrous cell layer count, and intramuscular changes were similar to those recorded in the control group, although the positive effects of PRP were not found to be statistically significant. Conclusions: The findings of the present study demonstrate that injections of PRP may increase joint inflammation and therefore enhance blood supply, resulting in the onset of regeneration. These favorable effects of PRP may be helpful in the fight against late-term musculoskeletal complications of RT and may minimize such side effects as sore jaw, malnutrition, and weight loss.

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Regenerative Approaches in Oral Medicine

Farah¹,

Celentano

Pantaleo

et al. 2021

Regenerative Approaches in Dentistry

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Chondrogenic effect of the perichondrium graft on the internal derangement and osteoarthritis of the temporomandibular joint of the rabbit

Cited by 6 publications

References 28 publications

Reduction of osteoarthritis severity in the temporomandibular joint of rabbits treated with chondroitin sulfate and glucosamine

Reduction of osteoarthritis severity in the temporomandibular joint of rabbits treated with chondroitin sulfate and glucosamine

The Effect of Platelet-Rich Plasma on the Temporomandibular Joint After Radiotherapy in Rabbits

Regenerative Approaches in Oral Medicine

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