Chondrogenic differentiation of adipose tissue-derived stem cells within nanocaged POSS-PCU scaffolds: A new tool for nanomedicine

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“…Moreover, it was shown that human adipose mesenchymal stem cells derived from pediatric patients differentiated into chondroblasts in POSS-PCU scaffolds, with consequent successful vascularization of the bionanocomposite. Cartilage grown in this way on POSS-PCU scaffold could be used for ear cartilage repair for children with congenital auricular malformations and other craniofacial defects, especially in cosmetic surgery [12]. Bone marrow mesenchymal cells were also able to undergo chondrogenesis on POSS-PCU auricular-shaped scaffold [13] and reassured the scientific community that tissue-engineered auricle using stem cells, will undoubtedly revolutionize surgical reconstruction of external ear cartilage.…”

The Use of Adipose Stem Cells in Cranial Facial Surgery

“…1 for adipose harvesting is relatively less painful compared to the bone marrow aspiration with decreased donor site morbidity and 10–100 times greater frequency of stromal cells per unit volume [29]. ADSCs are attractive options for tissue regeneration due to their angiogenic, wound healing and immunodulatory properties [30–45]. …”

“…ADSCs can undergo osteogenic differentiation in vitro by exposure to a combination of ascorbate, β-glycerophosphate, various bone morphogenetic proteins (BMPs), dexamethasone, and/or vitamin D3, confirming bone formation using Alizarin Red or Von Kossa staining, usually over a two-week period [45]. Several studies have shown that ADSCs will express multiple markers for osteogenesis in these conditions including cbfa-1, alkaline phosphatase, osteopontin, osteocalcin and collagen I [46, 47].…”

What’s up in nanomedicine?

“…No apparent negative reaction was observed. Guasti and coworkers (12) suggested that these scaffolds might be of great value for several applications such as the improvement of tracheal transplants.…”