Chondroblastic osteosarcoma: characterisation by gadolinium-enhanced MR imaging correlated with histopathology

Geirnaerdt, M. J. A.; Bloem, Johan L.; Woude, H. J. van der; Taminiau, A. H. M.; Nooy, M. A.; Hogendoorn, Pancras C.W.

doi:10.1007/s002560050354

Cited by 29 publications

(17 citation statements)

References 11 publications

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“…However, in spite of recent improvements in MRI (20), the histological diagnosis of bone tumors by MRI is still difficult. Geirnaerdt et al (17) demonstrated that septonodular and peripheral rim enhancement observed on Gd-enhanced MR images supported the diagnosis of a chondroblastic osteosarcoma. However, our results demonstrate that septonodular and peripheral rim enhancement patterns are characteristic patterns for chondroid matrix-forming tumors (21,22), not exclusively for chondroblastic osteosarcomas.…”

Section: Discussionmentioning

confidence: 99%

“…For the Gd-enhanced MR images, the classification of the enhancement pattern described by Geirnaerdt et al (17), as (a) none, (b) septonodular, when curvilinear lines and nodules were observed within an otherwise nonenhancing areas, (c) heterogeneous, or (d) rim, when an enhancing peripheral rim of variable thickness was seen. These patterns were not mutually exclusive in one tumor.…”

Section: Image Analysismentioning

confidence: 99%

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Characterization of chondroblastic osteosarcoma: Gadolinium‐enhanced versus diffusion‐weighted MR imaging

Yakushiji

Oka

Sato

et al. 2009

Magnetic Resonance Imaging

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Purpose: To detect differences in magnetic resonance imaging (MRI) between chondroblastic osteosarcoma and the other types of osteosarcomas or chondrosarcomas using gadolinium-enhanced versus diffusion-weighted sequences. Materials and Methods:Contrast-enhanced MRI and diffusion-weighted imaging (DWI) were performed in five chondroblastic osteosarcoma (CO) cases, 17 other types of osteosarcomas (OS), and 18 chondrosarcomas (CS). DWI was obtained with a single-shot echo-planar imaging (EPI) sequence using a 1.5T MR imager. The apparent diffusion coefficients (ADCs) of the minimum and maximum values were also obtained. The contrast-enhancement pattern was evaluated and minimum-maximum ADC value of CO was compared with other types of OS and CS.Results: Both CO and CS showed a similar enhancement pattern; both showed septonodular and peripheral rim enhancement. The minimum ADC value of CO (1.24 Ϯ 0.10 ϫ 10 Ϫ3 mm 2 /sec) was significantly higher than that of other types of OS (0.84 Ϯ 0.15 ϫ 10 Ϫ3 mm 2 /sec) and was significantly lower than that of CS (1.64 Ϯ 0.20 ϫ 10 Ϫ3 mm 2 /sec). In addition, the maximum ADC value of CO (2.28 Ϯ 0.20 ϫ 10 Ϫ3 mm 2 /sec) was significantly higher than that of other types of OS (1.33 Ϯ 0.26 ϫ 10 Ϫ3 mm 2 /sec).Conclusion: DWI appears to be more useful for differentiating between chondroblastic osteosarcoma and chondrosarcoma or other types of osteosarcoma than Gd-enhanced MRI.

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Section: Discussionmentioning

confidence: 99%

Section: Image Analysismentioning

confidence: 99%

Characterization of chondroblastic osteosarcoma: Gadolinium‐enhanced versus diffusion‐weighted MR imaging

Yakushiji

Oka

Sato

et al. 2009

Magnetic Resonance Imaging

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“…There are also results to suggest that the use of contrast medium may contribute to the accuracy of bone lesion detection in MRI. This is the case especially in recurrent malignancies and in certain types of cartilaginous lesions [19]; however, we did not find any advantage in lesion visualization when contrast was used. It is to be noted that our data did not include any primary malignant bone or cartilaginous tumors.…”

Section: Discussionmentioning

confidence: 82%

MRI-guided trephine biopsy and fine-needle aspiration in the diagnosis of bone lesions in low-field (0.23 T) MRI system using optical instrument tracking

et al. 2001

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The purpose of this study was to evaluate the feasibility of MRI-guided bone biopsy with optical instrument tracking and evaluate advantage of combined fine-needle aspiration (FNA) with trephine biopsy. Twenty trephine bone biopsies and 13 FNAs were performed under MRI and CT guidance in 14 patients. Informed consent was obtained from all patients. The evaluation of diagnostic accuracy was achieved by comparing the histopathological and cytological diagnosis with current or final diagnosis made during 6-month clinical follow-up. A 0.23-T open MRI scanner with interventional tools (Outlook Proview, Marconi Medical Systems, Cleveland, Ohio) was used. A surface coil was used. For trephine biopsy MRI-compatible bone biopsy set (Daum medical, Schwerin, Germany) was used. The FNA was performed with MRI compatible 20-G needle (Cook, Bloomington, Ind.). The diagnostic accuracy of MRI-guided trephine biopsy was 95%. The FNA sample diagnosis concurred with the histological in 54%. Our results show that MRI guidance in bone biopsies is accurate and safe. It is comparable to CT-guided or open biopsy. The role of combined FNA with bone biopsies remains controversial.

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“…The MRI has a better sensitivity and tissue contrast than CT. For example, oedematous lesions in bone can often be visualized only in MRI as a bright involvement of bone marrow in a heavily T2-weighted and short tau inversion recovery (STIR) sequences [8,10]. Contrast medium provides more accuracy in detecting viable parts in, for example, recurrent malignancies and certain types of cartilaginous lesions [31]. Parkkola et al [32] showed that, with dynamic contrast-enhanced MRI, biopsies can be taken from the vital part of the tumour avoiding the necrotic areas.…”

Section: Discussionmentioning

confidence: 98%

Cost comparison analysis of low-field (0.23�T) MRI- and CT-guided bone biopsies

et al. 2004

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The aim of this study was to analyze and compare the costs of low-field (0.23 T) MRI- and CT-guided bone biopsies. The cost comparison consisted of 18 MRI-guided and 12 CT-guided bone biopsies performed during a 1-year period. The costs and activities of these two methods were analyzed by using activity-based cost accounting (ABC). The costs of MRI-guided bone biopsy (1205 Euro) were 2.55-fold compared with those of the CT-guided bone biopsy (472 Euro). The higher costs of the biopsy procedure in MRI were due to the higher material (5.57-fold) and personnel (2.73-fold) costs. The MRI-guided bone biopsies proved to be considerably more expensive than CT-guided bone biopsies. This was due to the higher material costs, especially the highly priced MRI compatible instrumentation and the longer procedure time. The MRI guidance in performing bone biopsies should be justified on the basis of the better accuracy and the lack of radiation. Evaluations of cost-effectiveness concerning MRI-guided bone biopsy are needed.

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Chondroblastic osteosarcoma: characterisation by gadolinium-enhanced MR imaging correlated with histopathology

Abstract: Gd-enhanced MR imaging can assist in obtaining diagnostic biopsy material of chondroblastic osteosarcoma by identifying both osteoid- and chondroid-forming areas.

Cited by 29 publications

References 11 publications

Characterization of chondroblastic osteosarcoma: Gadolinium‐enhanced versus diffusion‐weighted MR imaging

Characterization of chondroblastic osteosarcoma: Gadolinium‐enhanced versus diffusion‐weighted MR imaging

MRI-guided trephine biopsy and fine-needle aspiration in the diagnosis of bone lesions in low-field (0.23 T) MRI system using optical instrument tracking

Cost comparison analysis of low-field (0.23�T) MRI- and CT-guided bone biopsies

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