Chondro-osseous respiratory epithelial adenomatoid hamartoma of the nasal cavity: a case report

Flavin, Richard; Russell, John; Phelan, Eimear; McDermott, Michael

doi:10.1016/j.ijporl.2004.07.010

Cited by 39 publications

(48 citation statements)

References 13 publications

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“…Examples of so-called COREAH (chondroosseous REAH) have been described, where either cartilage or bone are present within a REAH [7,8], which still could be in keeping with a hamartomatous process given the normal appearance of these structures in the nasal cavity. The chondro-osseous components could alternatively be normal structures entrapped by the REAH rather than a part of the proliferation.…”

Section: Respiratory Epithelial Adenomatoid Hamartomamentioning

confidence: 99%

Low Grade Glandular Lesions of the Sinonasal Tract: A Focused Review

Weinreb

2010

Head and Neck Pathol

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The sinonasal tract is a complex anatomic site with an exhaustive list of possible diagnoses. While most biopsies or resections encountered routinely consist of common diagnoses such as inflammatory polyps and papillomas, occasional cases are more difficult, and separating reactive or benign from malignancy can be challenging. One of the most poorly understood and daunting categories is low grade glandular or tubular proliferations, particularly on small biopsies. Possible diagnoses such as reactive lesions, respiratory epithelial adenomatoid hamartoma (REAH), seromucinous (glandular) hamartoma (SH) and low grade sinonasal adenocarcinomas (LGSNAC) must be entertained. REAH is composed of respiratory epithelial lined submucosal glands with variable connection to the surface and periglandular hyalinization. SH is a tubular proliferation reminiscent of normal serous glands which may be associated with REAH.LGSNAC is a diverse group of bland tubular and/or papillary tumors, which have a recurrence potential but an as yet uncertain potential for metastasis or mortality. The management for these lesions can be vastly different and conservative management is preferable, making this distinction more than academic. However, complicating this category are controversies surrounding their nature as reactive lesions versus neoplasms, the histologic and immunohistochemical overlap, and possible precursor relationships between some of them.

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Section: Respiratory Epithelial Adenomatoid Hamartomamentioning

confidence: 99%

Low Grade Glandular Lesions of the Sinonasal Tract: A Focused Review

Weinreb

2010

Head and Neck Pathol

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“…The bulk of the cases that have been reported have been in males in the third to ninth decades of life [2,6]. These masses occur in the nasal cavity, paranasal sinuses, and nasopharynx [2][3][4][5][6][7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Respiratory Epithelial Adenomatoid Hamartoma: A Review

Fitzhugh

Mirani

2008

Head and Neck Pathol

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Respiratory epithelial adenomatoid hamartoma (REAH) is an uncommon lesion of the upper aerodigestive tract first described by Wenig and Heffner in 1995 as prominent glandular proliferations lined by ciliated respiratory epithelium originating from the surface epithelium. The entity is seen most often in male adults. Clinically the lesion presents as a polypoid mass, often in one or both nasal cavities, though other locations have been described. While REAH is benign, awareness and recognition of the lesion is important because it can be easily confused grossly and microscopically with more threatening tumors such as inverted papilloma and sinonasal carcinoma. The literature of REAH is reviewed with detail paid to the histologic diagnosis. The clinical presentation, radiologic findings, and differential diagnosis are also described.

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“…Lokal rekür-rens nadirdir. 8 Ayırıcı tanıda yer alan diğer lezyonların tedavisi daha agresif cerrahi ile yapılır. Bu özellikleri nedeniyle REAH'nın radyolojik olarak tanınması cerrahi yaklaşımı değiştirmesi nedeniyle sinonazal kavite kitleleri içinde önem taşımaktadır.…”

Section: Discussionunclassified

Respiratory epithelial adenomatoid hamartoma on the anterior nasal septum

Bozkurt¹,

Koc²,

Altay³

et al. 2012

Dicle Med J

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Respiratory epithelial adenomatoid hamartoma (REAH) is a rare benign lesion of the sinonasal cavity. In this report, by physical examination in the anterior part of the nasal cavity, on the septum a mass lesion was detected and paranasal sinus computed tomography (PSCT) performed. On PSCT; bounded, homogenious, solid lesion was shown and no evidence of invasion of surrounding bone and cartilage structures. Histopathologic diagnosis of the lesion was evaluated as REAH. Though REAH is a very rare benign lesion of sinonasal cavity the treatment is only simple excision. Therefore keeping it in mind in differential diagnosis list, aggressive surgical procedures should be avoided. The clinical and radiological features are discussed in the light of the literature.

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Chondro-osseous respiratory epithelial adenomatoid hamartoma of the nasal cavity: a case report

Cited by 39 publications

References 13 publications

Low Grade Glandular Lesions of the Sinonasal Tract: A Focused Review

Low Grade Glandular Lesions of the Sinonasal Tract: A Focused Review

Respiratory Epithelial Adenomatoid Hamartoma: A Review

Respiratory epithelial adenomatoid hamartoma on the anterior nasal septum

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