Chondro‐osseous respiratory epithelial adenomatoid hamartoma of the nasal cavity

Abstract

Chondro-osseous respiratory epithelial adenomatoid hamartoma is a rare hamartomatous lesion of the nasal cavity, with only five cases reported in the literature to date. We report the case of a 3-year-old boy who presented with nasal obstruction and a mass in the left nasal cavity. The mass was completely resected on endoscopy. On microscopy, hamartomatous proliferation of respiratory-type glands admixed with islands of immature hyaline cartilage, characteristic of chondro-osseous respiratory epithelial adenomatoid hamartoma, was seen. Neither local recurrence nor distant metastasis was observed after 6 month follow up. Recognition of chondro-osseous respiratory epithelial adenomatoid hamartoma as a benign lesion is important to avoid unnecessary surgical procedures.

Bizarre stromal cells mimicking malignancy in chondro‐osseous respiratory epithelial adenomatoid hamartoma

“…The myofibroblastic origin of bizarre stromal cells has been supported both by ultrastructural and immunohistochemical findings (immunopositivity for CD68 antigen, smooth muscle actin, vimentin, variable positivity in keratins and immunonegativity for desmin, myoglobin, glial fibrillary acidic protein and S100 protein) . The differences in immunostaining observed in our case (positivity for S100 protein, glial fibrillary acidic protein and absence of positivity for smooth muscle actin and keratins), along with the fact that bizarre stromal cells have not been reported in any of the previously published cases of COREAH, highlight the need for detailed evaluation of the morphological and immunohistochemical findings in case series in the future.…”

“…Chondro-osseous respiratory epithelial adenomatoid hamartoma (COREAH), is a rare entity, with only 21 cases having been reported in the literature so far. [1][2][3] We report the case of a 64-year-old female patient who presented with a one-year history of left sided nasal obstruction, non-responsive to medical treatment with antihistamines. Clinical examination with anterior rhinoscopy and flexible nasendoscopy revealed a smooth, polypoid mass, occupying almost entirely the left nasal cavity.…”

“…Chondro‐osseous respiratory epithelial adenomatoid hamartoma (COREAH), is a rare entity, with only 21 cases having been reported in the literature so far …”

Chondro-Osseous Respiratory Epithelial Adenomatoid Hamartoma (COREAH): Case Report and Literature Review

“…Respiratory epithelial adenomatoid hamartoma (REAH) has long been identified as a solely epithelial hamartoma of the sinonasal tract, while nasal chondromesenchymal hamartoma (NCMH) has been identified as a solely mesenchymal hamartoma. It has been suggested that COREAH lies in the spectrum between REAH and the DICER 1 familial disorder NCMH as it encompasses elements of each entity, both epithelial and mesenchymal [2]. However, it should be noted that to date, COREAH has not been observed in DICER 1 patients and thus may represent a completely different entity.…”

Giant hamartoma of the nasopharynx – case report

“…1 Depend� ing on the amount of the cellular substance two hamarto� ma forms are distinguished: epithelial and mesenchymal, wherein the latter occurs significantly more often. 2 Among the mesenchymal tissue cells four main types are identified: osteal, chondral, fibrous, benign non-matrix. 3,4 In the fea� tured case, the tumour character was chondromesenchymal.…”