Chondrichthyes: The Immune System of Cartilaginous Fishes

Dooley, Helen

doi:10.1007/978-3-319-76768-0_18

Cited by 2 publications

(2 citation statements)

References 131 publications

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“…In addition to classic MHC class II genes, most jawed vertebrates have non-classic MHC class II genes [ 42 ]. In particular, the conservation of MHC II sequences from cartilaginous fish to humans is known [ 43 , 44 , 45 ]. A genetic lineage of MHC II class molecules (MHC II-D) has been identified in bony fishes.…”

Section: Methodsmentioning

confidence: 99%

Confocal Characterization of Intestinal Dendritic Cells from Myxines to Teleosts

Alesci

Capillo

Fumia

et al. 2022

Biology

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Dendritic cells (DCs) are antigen-presenting cells (APCs) that regulate the beginning of adaptive immune responses. The mechanisms of tolerance to antigens moving through the digestive tract are known to be regulated by intestinal DCs. Agnatha and Gnathostoma are descendants of a common ancestor. The Ostracoderms gave rise to Cyclostomes, whereas the Placoderms gave rise to Chondrichthyes. Sarcopterygii and Actinopterygii are two evolutionary lines of bony fishes. Brachiopterygii and Neopterygii descend from the Actinopterygii. From Neopterygii, Holostei and Teleostei evolved. Using immunohistochemistry with TLR-2, Langerin/CD207, and MHC II, this study aimed to characterize intestinal DCs, from myxines to teleosts. The findings reveal that DCs are positive for the antibodies tested, highlighting the presence of DCs and DC-like cells phylogenetically from myxines, for the first time, to teleosts. These findings may aid in improving the level of knowledge about the immune system’s evolution and these sentinel cells, which are crucial to the body’s defense.

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Section: Methodsmentioning

confidence: 99%

Confocal Characterization of Intestinal Dendritic Cells from Myxines to Teleosts

Alesci

Capillo

Fumia

et al. 2022

Biology

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“…The average and median values of CDR3 length in the spleen were both the highest among the three libraries, although still shorter than those of shark VNARs. In cartilaginous fish, B cells are generated in the epigonal organ, and the spleen is the major secondary lymphoid organ (Rumfelt et al, 2002;Dooley, 2018). Our results suggest that, in O. kenojei B-cell development, CDR3 length may slightly increase due to B-cell clonal selection.…”

Section: The Ocellate Spot Skate Vnar Diversity and Repertoire Charac...mentioning

confidence: 75%

Identification and characterization of IgNAR and VNAR repertoire from the ocellate spot skate (Okamejei kenojei)

Wen

Gong

et al. 2023

Front. Mar. Sci.

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Elasmobranchs are crucial for comparative studies of evolution, as they belong to the most ancient vertebrate lineages that survived numerous extinction events and persist until today. The immunoglobulin new antigen receptor (IgNAR) found in sharks and heavy-chain-only antibody (HCAb) found in camelidae are products of convergent evolution. Although it was previously believed that IgNAR emerged 220 million years ago, before the divergence of sharks and skates, there is limited evidence to support this. In this study, we provide data supporting the existence of IgNAR in the ocellate spot skate (Okamejei kenojei) mononuclear cell transcriptome and peripheral blood serum. Additionally, we characterize the germline gene configuration of the ocellate spot skate IgNAR V domain. The ocellate spot skate IgNAR structure prediction and VNAR crystal structure exhibit high similarity to their shark counterparts. These data strongly suggest that IgNAR in both sharks and skates share a common ancestor. Sequencing of the ocellate spot skate VNAR repertoire provided crucial data for further understanding of the IgNAR generation. Notably, we discovered that approximately 99% of the ocellate spot skate VNARs belonged to type IV. This represents an exceptionally high proportion of type IV within the VNAR repertoire, which has not been documented in previously studied elasmobranchs. This unique characteristic of the ocellate spot skate VNAR adds essential structural diversity to the naïve VNAR library from elasmobranchs and could potentially benefit the development of pharmaceutical drugs.

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Chondrichthyes: The Immune System of Cartilaginous Fishes

Cited by 2 publications

References 131 publications

Confocal Characterization of Intestinal Dendritic Cells from Myxines to Teleosts

Confocal Characterization of Intestinal Dendritic Cells from Myxines to Teleosts

Identification and characterization of IgNAR and VNAR repertoire from the ocellate spot skate (Okamejei kenojei)

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