Chondral Resurfacing of Articular Cartilage Defects in the Knee with the Microfracture Technique

Mithoefer, Kai; Williams, Riley J.; Warren, Russell F.; Potter, Hollis G.; Spock, Christopher; Jones, Edward C.; Wickiewicz, Thomas L.; Marx, Robert G.

doi:10.2106/00004623-200609001-00013

Cited by 116 publications

(18 citation statements)

References 7 publications

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“…The fibrous cartilage is softer than hyaline cartilage and is easily damaged due to low biomechanical strength [22]. Another potential risk is that microfracture may create loose bodies, which may cause locking and cartilage damage if not properly removed [23, 24]. So at the end of the arthroscopy surgery, we all carefully inspected the ankle joint for removing visible loose bodies.…”

Section: Discussionmentioning

confidence: 99%

Comparison of distraction arthroplasty alone versus combined with arthroscopic microfracture in treatment of post-traumatic ankle arthritis

Zhang

Jiang

et al. 2017

J Orthop Surg Res

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BackgroundThis study aims to compare clinical outcomes of distraction arthroplasty alone versus combined with arthroscopic microfracture in treating post-traumatic ankle arthritis.MethodsThe study cohort consisted of 96 patients (96 ankles) who underwent distraction arthroplasty alone or combined with arthroscopic microfracture between May 2005 and April 2012. Patients were divided into the distraction group (n = 46) and the combined group (n = 50). The American Orthopaedic Foot and Ankle Society (AOFAS) score, visual analog scale (VAS), and ankle activity score (AAS) were used to compare the clinical outcomes between groups. Arthritis severity was assessed on the radiograph.ResultsAt the mean follow-up period of 30.8 ± 3.1 and 31.4 ± 3.6 months, respectively, no severe complications occurred and no further surgical interventions for symptomatic arthritis were required in both groups. The AOFAS scores improved significantly in the combined group than in the distraction group (59.0 ± 4.7 and 58.0 ± 4.9 preoperatively versus 85.0 ± 4.9 and 88.9 ± 5.4 at final visit, P < 0.001). The AAS scores were also significantly higher in the combined group (3.6 ± 1.1 and 3.3 ± 1.0 preoperatively versus 6.5 ± 1.1 and 7.1 ± 1.3 at final visit, P = 0.009). Pain was significantly alleviated in the combined group by the VAS scores (6.4 ± 0.9 and 6.7 ± 0.9 preoperatively versus 2.3 ± 0.8 and 2.0 ± 0.7 at final visit, P = 0.040). The combined group achieved better radiographic arthritis severity decrease than the distraction group (P = 0.012).ConclusionsCompared to distraction arthroplasty alone, distraction arthroplasty combined with arthroscopic microfracture can offer better functional recovery, pain relief, and ankle arthritis resolution for treating post-traumatic ankle arthritis.

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Section: Discussionmentioning

confidence: 99%

Comparison of distraction arthroplasty alone versus combined with arthroscopic microfracture in treatment of post-traumatic ankle arthritis

Zhang

Jiang

et al. 2017

J Orthop Surg Res

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“…e hematoma that contains mesenchymal stem cells (MSCs) are [35,36]. Although this method is relatively fast, the hematoma cannot totally fill the defect [37].…”

Section: Different Treatments For Articular Cartilage Damage (Healingmentioning

confidence: 99%

Hydrogels for the Application of Articular Cartilage Tissue Engineering: A Review of Hydrogels

Chuang

Chiang

Wong

et al. 2018

Advances in Materials Science and Engineering

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e treatment of articular cartilage damage is a major task in the medical science of orthopedics. Hydrogels possess the ability to form multifunctional cartilage grafts since they possess polymeric swellability upon immersion in an aqueous phase. Polymeric hydrogels are capable of physiological swelling and greasing, and they possess the mechanical behavior required for use as articular cartilage substitutes. e chondrogenic phenotype of these materials may be enhanced by embedding living cells. Artificial hydrogels fabricated from biologically derived and synthesized polymeric materials are also used as tissue-engineering scaffolds; with their controlled degradation profiles, the release of stimulatory growth factors can be achieved. In order to make use of these hydrogels, cartilage implants were formulated in the laboratory to demonstrate the bionic mechanical behaviors of physiological cartilage. is paper discusses developments concerning the use of polymeric hydrogels for substituting injured cartilage tissue and assisting tissue growth. ese gels are designed with consideration of their polymeric classification, mechanical strength, manner of biodegradation, limitations of the payload, cellular interaction, amount of cells in the 3D hydrogel, sustained release for the model drug, and the different approaches for incorporation into adjacent organs. is article also summarizes the different advantages, disadvantages, and the future prospects of hydrogels.

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“…Early-stage interventions are available and focus on initiating cell-based repair. Reparative techniques such as abrasion arthroplasty [14], debridement [15] and microfracture [16] aim to encourage infiltration of stem cells from the marrow spaces of the underlying subchondral bone, to stimulate repair of the damaged tissue. Restorative techniques such as mosaicplasty [17] involve removing cartilage plugs from non-load-bearing regions of the joint and implanting them into the osteochondral defect zone.…”

Section: Myopathiesmentioning

confidence: 99%

Augmentation of Musculoskeletal Regeneration: Role for Pluripotent Stem Cells

2018

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The rise in the incidence of musculoskeletal diseases is attributed to an increasing ageing population. The debilitating effects of musculoskeletal diseases, coupled with a lack of effective therapies, contribute to huge financial strains on healthcare systems. The focus of regenerative medicine has shifted to pluripotent stem cells (PSCs), namely, human embryonic stem cells and human-induced PSCs, due to the limited success of adult stem cell-based interventions. PSCs constitute a valuable cell source for musculoskeletal regeneration due to their capacity for unlimited self-renewal, ability to differentiate into all cell lineages of the three germ layers and perceived immunoprivileged characteristics. This review summarizes methods for chondrogenic, osteogenic, myogenic and adipogenic differentiation of PSCs and their potential for therapeutic applications.

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Chondral Resurfacing of Articular Cartilage Defects in the Knee with the Microfracture Technique

Cited by 116 publications

References 7 publications

Comparison of distraction arthroplasty alone versus combined with arthroscopic microfracture in treatment of post-traumatic ankle arthritis

Comparison of distraction arthroplasty alone versus combined with arthroscopic microfracture in treatment of post-traumatic ankle arthritis

Hydrogels for the Application of Articular Cartilage Tissue Engineering: A Review of Hydrogels

Augmentation of Musculoskeletal Regeneration: Role for Pluripotent Stem Cells

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