Cholinogenic Urticaria and Cholinogenic Itching

Nomland, Ruben

doi:10.1001/archderm.1944.01510160019009

Cited by 25 publications

(5 citation statements)

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“…Intense pruritus and burning induced by heat, exercise, hot food or emotion, which was relieved by cooling, was once termed cholinergic pruritus . When exercise and warmth‐induced pruritus was accompanied solely by a macular punctuate or generalized erythema, it was called cholinergic erythema .…”

Section: Discussionmentioning

confidence: 99%

Cholinergic urticaria: More than a simple inducible urticaria

Kim

Lee

2016

Aust J Dermatology

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Section: Discussionmentioning

confidence: 99%

Cholinergic urticaria: More than a simple inducible urticaria

Kim

Lee

2016

Aust J Dermatology

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“…It primarily affects whole body in response to increased core body temperature, sunlight exposure, exercise/physical activities, warm atmosphere/clothing, emotional stress, and hot and spicy food intake. [ 1 2 ] There is a paucity of data related to management of cholinergic itch in the current literature, even though in some cases it can severely compromise the quality of life. In this report we have tried to assess the role of cyclosporine in severe cholinergic itch refractory to anti-histamine therapy.…”

Section: Introductionmentioning

confidence: 99%

Cyclosporine in Cholinergic Itch

Mittal

Sehgal

Arora

et al. 2022

Indian Dermatology Online Journal

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Cholinergic itch is part of symptom complex that also includes cholinergic erythema and cholinergic urticaria. It mostly occurs during the winters among young adults. It is characterized by onset of severe itching or burning sensation all over body, mostly, on exposure to sunlight, warm atmosphere and in some cases after hot and spicy food intake. In most of the cases, it is poorly responsive to antihistamine therapy. Materials and methods: This was a prospective, open labeled, clinical study done in patients of cholinergic itch, refractory to both sedating and non sedating anti-histamine drugs, who attended dermatology clinic of our tertiary care center from November, 2020 to February, 2021. Oral cyclosporine was given as treatment. Numerical rating scale (NRS) was used to record the treatment response. Results: Twenty patients with cholinergic itch meeting inclusion criteria were included in the study. Mean age of disease onset was 19.5 years. Average duration of each episode was 4.4-8 minutes. More than one site was involved in all patients with trunk being the commonest (100%). There was significant reduction in the number of episodes and cholinergic itch severity (mean NRS=7.8 to 0.3 at the end of second week after initiating cyclosporine therapy). P value of the study was <0.0001. Statistics: Mean and standard deviation were used as measure of central tendency. Paired t test was applied to analyze the data obtained. Conclusion: Oral cyclosporine effectively controlled cholinergic itch in all included patients. Drug was well tolerated by the patients.

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“…3. Direct and indirect basophil degranulation tests in vitro were negative for cold antibodies as well as antibodies to acetylcholine.8 4.…”

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confidence: 98%

“…Laboratory Studies.-Hematological determinations re¬ vealed the hemoglobin to be 14.2 gm/100 cc, and the white blood cell (WBC) count, 4,500 ( neutrophils, 51; eosinophils, 3 Special Studies.-The urticaria, although induced by various means, always had the same characteristics. The raised lesion was a pruritic, perifollicular papule from 1 to 3 mm in diameter with an irregular zone of erythema of approximately 1.5 to 3.0 cm in diameter.…”

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confidence: 98%