Cholinesterase and microbial inhibitory activities of Tetrapleura tetraptera

Abstract

Abstract:The cholinesterase and microbial inhibitory activities of different parts of Tetrapleura tetraptera plant were evaluated due to their local applications. The cholinesterase results revealed that the extracts showed some levels of inhibitory effects depending on the solvents used. Tetrapleura tetraptera leaves had better inhibitory effects with maximum inhibitory activity of 70.0% at a concentration of 1.00mg/l for the water extract. Tetrapleura tetraptera bark showed highest inhibitory effect of 71.05% and (84.34%) for the ethanol and chloroform extracts at concentrations of 0.5mg/l and 1.0 mg/l respectively. While for petroleum ether, T. tetraptera bark recorded 74.34% inhibitory effect at concentration of 2.0 mg/l and also showed continuous increase in inhibitory activity as the concentration increases for aqueous methanol. The results of the antimicrobial activities showed that among all the test organisms, the ethanol and water extracts of the leaves, stem, bark and root of the plants had promising activity against Escherichia coli, Staphylococcus aureus, Proteus mirabilis, Pseudomonas aeruginosa and Klebsiella pneumonia bacteria and Aspergillus fumigatus and Rhizopus species fungi. There was no activity shown by the ethanol and water extracts of the parts of the plants with Fugarium oxysporum, Penicillium chrysogenum and Mucor species fungi. The bacteria strains were more sensitive to the tested extracts than the fungi strains.

Antibacterial, Antifungal and Anti-tubercular Activities of Chloroform Fraction of the Leaf Extract of Irvingia Gabonensis (African Bush Mango)

“…The phytochemical analysis of the chloroform fraction revealed the presence of alkaloid, tannin, flavonoid, phenol, saponin and coumarin. The presence of these families of compounds in fraction confirms the results of previous studies on the extracts of I. gabonensis [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29]. These phytochemicals confirm the pharmacological properties reported previously such as anti-ulcer and anti-diarrhoea [23], antioxidant [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24], anti-inflammatory [6], anti-cancer [25] and anti-microbial activities [11][12][13][14][15]…”

“…The result obtained reveals highest antifungal activity value against C. albicans at 2.5 mg/mL (5 mm) and lowest activity value for C. albicans at 25 mg/mL (14 mm). The MIC values obtained in this study are compared favourably with those reported in the literature for some of the test organisms [10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29]. Figs (3 and 4) show the MIC charts for both bacteria and fungi against the chloroform fraction.…”

“…The extraction of Irvingia gabonensis leaves was carried out using known standard procedures [12]. Air-dried leaves were ground into powder with a mechanical grinder.…”

Topically Applied Tetrapleura tetraptera Stem-Bark Extract Promotes Healing of Excision and Incision Wounds in Rats

“…The stem-bark of T. tetraptera has been shown to possess antiulcerative, antibacterial and antioxidant potential that could be attributed to a wound healing potential [ 13 , 19 , 20 ]. On this basis, the present study was designed to evaluate the wound healing effect of the water extract of the bark on excisional and incisional wound models.…”

Biopreservative Potential of the Spices; Piper Guineense (Uziza), Xylopia Aethiopica (Uda) and Tetrapleura Tetraptera (Oshorisho) in Fresh Fruit Juices

“…These spices have shown promise in the inhibition of microbial growth. Okoronkwo and Echeme (2012) reported that extracts of T. tetraptera effectively inhibited the growth of E. coli, S. aureus and Proteus mirabilis with resultant zones of inhibition of 5.00 -18.00 mm for the leaves, stem, bark and roots etc [25]. indicating that extracts of T. tetraptera can be bacteriostatic/bacteriocidal against these test pathogens.…”