Cholinergic sprouting in the rat fascia dentata after entorhinal lesion is not linked to early changes in neurotrophin messenger RNA expression

Förster, Eckart; Naumann, T.; Deller, Thomas; Straube, A; Nitsch, Robert; Frotscher, Michael

doi:10.1016/s0306-4522(97)00054-7

Cited by 23 publications

(11 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Selective adhesive factors demonstrated in other models (Emerling and Lander, 1994;Fo « rster et al, 1998;Fo « rster, 2001) may be important here. Dissociated cells prelabeled with the DiI cell tracker or with FLM were seeded onto slices from P5 animals, left undisturbed for 2 h, and then gently rinsed with culture medium.…”

Section: Does the Non-random Distribution Of Ache-positive Neurons Rementioning

confidence: 66%

“…The seeding of dissociated cells onto slices of potential target tissue is a powerful method of investigating cellĉ ell interactions in developing brain (Emerling and Lander, 1994;Fo « rster et al, 1998;Fo « rster, 2001;Halloran and Kalil, 1996;Laywell et al, 1996; Robertson et al, 1997). In normal brain development, of course the somata and dendrites of basal forebrain neurons do not come in contact with cortical structures.…”

Section: Technical Considerationsmentioning

confidence: 99%

“…The projection from medial septum to the dentate gyrus displays one of the more clearly layered patterns of termination by cholinergic a¡erents (Amaral and Witter, 1995;Baratta et al, 1996a,b;Deller, 1998;Deller et al, 1999;Fo « rster et al, 1997;Makuch et al, 2001;Storm-Mathisen and Blackstadt, 1964;Super and Soriano, 1994;Zimmer et al, 1986), and it is this layered quality that makes this region an ideal model system for this study. Septal cholinergic projections to the dentate gyrus terminate principally in the inner molecular layer, although termination also occurs in the outer molecular layer and, to some extent, within the hilus (Amaral and Witter, 1995;Deller et al, 1999;Makuch et al, 2001;Milner et al, 1983;Super and Soriano, 1994).…”

Section: Technical Considerationsmentioning

confidence: 99%

“…Development of cholinergic projections from the septum to the hippocampal dentate gyrus (Amaral and Kurz, 1985;Armstrong et al, 1987;Deller, 1998;Fo « rster et al, 1997;Lewis and Shute, 1967;Luiten et al, 1987;McKinney et al, 1983;Milner et al, 1983;Shute and Lewis, 1967;Storm-Mathisen and Blackstadt, 1964;Wenk et al, 1980;Woolf, 1991;Zimmer et al, 1986) provides an excellent model system for studies of axon targeting. The reasons are as follows.…”

mentioning

confidence: 99%

“…The reasons are as follows. First, the axons of septal cholinergic neurons form a distinct pattern of termination in the inner molecular layer of the dentate gyrus (Amaral and Witter, 1995;Baratta et al, 1996a,b;Deller, 1998;Fo « rster et al, 1997;Lewis and Shute, 1967;Storm-Mathisen and Blackstadt, 1964;Zimmer et al, 1986), suggesting that communication between the septal cholinergic axons and the dentate gyrus granule cells is important for establishing this pattern of connectivity. Second, septal and other basal forebrain cholinergic neurons (BFCNs) express high levels of acetylcholinesterase (AChE), which is present throughout the neurons Woolf, 1991), including their axon terminals.…”

mentioning

confidence: 99%

See 4 more Smart Citations

Basal forebrain cholinergic cell attachment and neurite outgrowth on organotypic slice cultures of hippocampal formation

et al. 2002

View full text Add to dashboard Cite

Section: Does the Non-random Distribution Of Ache-positive Neurons Rementioning

confidence: 66%

Section: Technical Considerationsmentioning

confidence: 99%

Section: Technical Considerationsmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Basal forebrain cholinergic cell attachment and neurite outgrowth on organotypic slice cultures of hippocampal formation

et al. 2002

View full text Add to dashboard Cite

Deafferentation enhances neurogenesis in the young and middle aged hippocampus but not in the aged hippocampus

Shetty¹,

Hattiangady

Rao

et al. 2011

Hippocampus

View full text Add to dashboard Cite

Increased neurogenesis in the dentate gyrus (DG) after brain insults such as excitotoxic lesions, seizures or stroke is a well known phenomenon in the young hippocampus. This plasticity reflects an innate compensatory response of neural stem cells (NSCs) in the young hippocampus to preserve function or minimize damage after injury. However, injuries to the middle-aged and aged hippocampi elicit either no or dampened neurogenesis response, which could be due to an altered plasticity of NSCs and/or the hippocampus with age. We examined whether the plasticity of NSCs to increase neurogenesis in response to a milder injury such as partial deafferentation is preserved during aging. We quantified DG neurogenesis in the hippocampus of young, middle-aged and aged F344 rats after partial deafferentation. A partial deafferentation of the left hippocampus without any apparent cell loss was induced via administration of Kainic acid (0.5 μg in 1.0 μl) into the right lateral ventricle of the brain. In this model, degeneration of CA3 pyramidal neurons and dentate hilar neurons in the right hippocampus results in loss of commissural axons which leads to partial deafferentation of the dendrites of dentate granule cells and CA1-CA3 pyramidal neurons in the left hippocampus. Quantification of newly born cells that are added to the dentate granule cell layer at post-deafferentation days 4-15 using 5′-bromodeoxyuridine (BrdU) labeling revealed greatly increased addition of newly born cells (~3 fold increase) in the deafferented young and middle-aged hippocampi but not in the deafferented aged hippocampus. Measurement of newly born neurons using doublecortin (DCX) immunostaining also revealed similar findings. Analyses using BrdU-DCX dual immunofluorescence demonstrated no changes in neuronal fate-choice decision of newly born cells after deafferentation, in comparison to the age-matched naive hippocampus in all age groups. Thus, the plasticity of hippocampal NSCs to increase DG neurogenesis in response to a milder injury such as partial hippocampal deafferentation is preserved until middle age but lost at old age.

show abstract

Induction of STAT3 Signaling in Activated Astrocytes and Sprouting Septal Neurons Following Entorhinal Cortex Lesion in Adult Rats

Xia

Hofmann

Deller

et al. 2002

Molecular and Cellular Neuroscience

View full text Add to dashboard Cite

Cholinergic sprouting in the rat fascia dentata after entorhinal lesion is not linked to early changes in neurotrophin messenger RNA expression

Cited by 23 publications

References 65 publications

Basal forebrain cholinergic cell attachment and neurite outgrowth on organotypic slice cultures of hippocampal formation

Basal forebrain cholinergic cell attachment and neurite outgrowth on organotypic slice cultures of hippocampal formation

Deafferentation enhances neurogenesis in the young and middle aged hippocampus but not in the aged hippocampus

Induction of STAT3 Signaling in Activated Astrocytes and Sprouting Septal Neurons Following Entorhinal Cortex Lesion in Adult Rats

Contact Info

Product

Resources

About