Cholinergic neuromodulation of prefrontal attractor dynamics controls performance in spatial working memory
Alexandre Mahrach,
David Bestue,
Xue-Lian Qi
et al.
Abstract:The behavioral and neural effects of the endogenous release of acetylcholine following stimulation of the Nucleus Basalis of Meynert (NB) have been recently examined (Qi et al. 2021). Counterintuitively, NB stimulation enhanced behavioral performance while broadening neural tuning in the prefrontal cortex (PFC). The mechanism by which a weaker mnemonic neural code could lead to better performance remains unclear. Here, we show that increased neural excitability in a simple continuous bump attractor model can i… Show more
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