Cholinergic Nerve Terminals in the Central Nervous System of Insects

Sattelle, David B.; Breert, H.

doi:10.1111/j.1365-2826.1990.tb00400.x

Cited by 38 publications

(24 citation statements)

References 94 publications

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“…In insects, sensory neurons are thought to use predominantly ACh as a neurotransmitter (Sattelle and Breer 1990) and many sensory neurons of the adult locust stain with an antibody against ChAT (Lutz and Tyrer 1987). Here, we show that mechanosensory neurons of the body wall (Meier and Reichert 1990), such as the segmentally arranged stretch receptors, stain for AChE (Fig.…”

Section: Staining Patternmentioning

confidence: 55%

Cellular expression patterns of acetylcholinesterase activity during grasshopper development

Bicker¹,

Naujock²,

Haase³

2004

Cell Tissue Res

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We examined the expression of acetylcholinesterase (AChE) in the nervous system and epidermal body structures during embryonic and larval development of two grasshopper species: Locusta migratoria and Schistocerca americana. Histochemical labelling was blocked by the enzyme inhibitors eserine and BW284c51, but not by iso-OMPA, showing that the staining reflected true AChE activity. The majority of staining was localized on the cell surface but granular intracellular staining was also visible in many cell bodies. In both species, the cellular expression of AChE followed a similar but complex spatiotemporal staining pattern. Initially, mainly epidermal tissue structures were stained in the various body appendages (stages 25%-30%). Labelling subsequently appeared in outgrowing neurons of the central nervous system (CNS) and in the nerves innervating the limbs and dorsal body wall (stages 30%-40%). The latter staining originated in motoneurons of the ventral nerve cord. In a third phase (after 45%), the somata of certain identified mechanosensory neurons started to express AChE activity, presumably reflecting cholinergic differentiation. Staining was also found in repo-positive glial cells of the CNS, longitudinal glia of connectives, glia of the stomatogastric nervous system and glial cells ensheathing peripheral nerves. Glial cells remained AChE-positive during larval to adult development, whereas motoneurons lost their AChE expression. The expression pattern in non-neuronal cells and glutamatergic motoneurons and the developmental appearance of AChE prior to synaptogenesis in the CNS suggest non-cholinergic functions of AChE during grasshopper embryogenesis.

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Section: Staining Patternmentioning

confidence: 55%

Cellular expression patterns of acetylcholinesterase activity during grasshopper development

Bicker¹,

Naujock²,

Haase³

2004

Cell Tissue Res

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“…It has been demonstrated that the postsynaptic neurons possess receptors which have an essentially nicotinic pharmacology: the most prominent effect of ACh is mediated by nicotinic receptors which generate fast excitatory postsynaptic potentials [47,48] Several data have been obtained from cholinergic synaptic transmission at the cercal afferent-giant interneuron synapse in the cockroach sixth abdominal ganglion. Individual giant interneurons can be identified by their unique morphological characteristics and localization [42,43,[49][50][51].…”

Section: Insect Postsynaptic Nicotinic Receptorsmentioning

confidence: 99%

Emerging Pharmacological Properties of Cholinergic Synaptic Transmission: Comparison between Mammalian and Insect Synaptic and Extrasynaptic Nicotinic Receptors

Thany¹,

Tricoire‐Leignel²

2011

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Acetylcholine (ACh) is probably the oldest signalling neurotransmitter which appeared in evolution before the nervous system. It is present in bacteria, algae, protozoa and plants. In insects and mammals it is involved in cell-to-cell communications in various neuronal and non-neuronal tissues. The discovery of nicotinic acetylcholine receptors (nAChRs) as the main receptors involved in rapid cholinergic neurotransmission has helped to understand the role of ACh at synaptic level. Recently, several lines of evidence have indicated that extrasynaptically expressed nAChRs display distinct pharmacological properties from the ones expressed at synaptic level. The role of both nAChRs at insect extrasynaptic and/or synaptic levels has been underestimated due to the lack of pharmacological tools to identify different nicotinic receptor subtypes. In the present review, we summarize recent electrophysiological and pharmacological studies on the extrasynaptic and synaptic differences between insect and mammalian nAChR subtypes and we discuss on the pharmacological impact of several drugs such as neonicotinoid insecticides targeting these receptors. In fact, nAChRs are involved in a wide range of pathophysiological processes such as epilepsy, pain and a wide range of neurodegenerative and psychiatric disorders. In addition, they are the target sites of neonicotinoid insecticides which are known to act as nicotinic agonists causing severe poisoning in insects and mammals.

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“…These include the filiform sensilla in the cercal system of cockroaches (Callec et al, 1971; for a review, see Sattelle and Breer, 1990), olfactory sensilla of adult moths (Waldrop and Hildebrand, 1989;Stengl et al, 1990), and tactile hairs in caterpillars (Trimmer and Weeks, 1989). In the locust thorax, ChAT has been extracted from sensory cell bodies (Emson et al, 1974), and many mechanosensory neurons are immunoreactive for this enzyme .…”

Section: Functions Of Acetylcholinementioning

confidence: 99%

Cytochemical evidence that acetylcholine is a neurotransmitter of neurons that make excitatory and inhibitory outputs in the locust ocellar visual system

Leitinger

Simmons

2000

J. Comp. Neurol.

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Cholinergic Nerve Terminals in the Central Nervous System of Insects

Cited by 38 publications

References 94 publications

Cellular expression patterns of acetylcholinesterase activity during grasshopper development

Cellular expression patterns of acetylcholinesterase activity during grasshopper development

Emerging Pharmacological Properties of Cholinergic Synaptic Transmission: Comparison between Mammalian and Insect Synaptic and Extrasynaptic Nicotinic Receptors

Cytochemical evidence that acetylcholine is a neurotransmitter of neurons that make excitatory and inhibitory outputs in the locust ocellar visual system

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