Cholinergic modulations and learning

Ce, Giurgea; Greindl, M.G.; Preat, S

doi:10.1016/0166-4328(83)90082-7

Cited by 2 publications

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“…It was also shown that piracetam activates brain adenyl kinase [Nickolson and Wolthuis, 1976], More recently, a rela tion with the central cholinergic mechanisms was postu lated since it was shown that piracetam reduces hippo campal acetylcholine levels in age [Bartus et al, 1981], naive and young rats [Wurtman et al, 1981;Pedata et al, 1984] after systemic administration. It was also shown that piracetam potentiates the positive effects of choline on learning and memory in young rats [Giurgea, 1983]. Thus, there is need to study the mode of action of piracetam by employing more direct procedures.…”

Section: Discussionmentioning

confidence: 99%

Effect of Drugs Acting on Monoaminergic and Cholinergic Systems on the Quantified EEG of Rats

Emilien¹

1989

Neuropsychobiology

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Five different classes of drugs (clonidine: 0, 0.10, 0.30, 0.50 mg/kg; yohimbine: 0, 2, 4, 8 mg/kg; haloperidol: 0, 0.02, 0.04, 0.08 mg/kg; piracetam: 0, 150, 300, 600 mg/kg, and eserine: 0, 0.10, 0.30, 0.50 mg/kg) were studied on two cortical EEG derivations as well as a deep structure, the locus ceruleus in the rats. Each drug affected the EEG in its own particular manner. Clonidine significantly decreased frequency in the theta band (3.7–7.5 Hz) and increased it in the alpha band (7.6–13.5 Hz). A general significant increase in power was observed. Yohimbine’s effects on the EEG varied according to the regions studied. There were significant modifications of power and frequency in the theta, alpha and beta bands in the three derivations studied. Notable effects of haloperidol were observed as an increase in power in all frequency bands at all doses administered particularly in the anteroparietal and posteroparietal derivations. In the locus ceruleus derivation, power was significantly increased at all doses only in the alpha and beta frequency bands. Concerning piracetam, while no significant effects were noted on the EEG frequency, this drug significantly increased EEG power in the posteroparietal and anteroparietal derivations. The most important effects are obtained at the lowest dose (150 mg/kg) administered. Finally, it was shown that eserine significantly decreased power in the delta bandwidth shortly after its administration. Afterwards, the power gradually regained its original level.

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Section: Discussionmentioning

confidence: 99%

Effect of Drugs Acting on Monoaminergic and Cholinergic Systems on the Quantified EEG of Rats

Emilien¹

1989

Neuropsychobiology

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Effect of combined or separate administration of piracetam and choline on learning and memory in the rat

Ennaceur

Delacour

1987

Psychopharmacology

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Different groups of rats received combined or separate administration of different doses of piracetam (P1:100, P2:200, and P4:400 mg/kg) and choline (C1:100 and C2:200 mg/kg). Compared to control treatment, C1 significantly improved performance in a delayed alternation (DA) task, while P1, P2, P4 or P1C1 had no effect. Moreover, rats receiving P2C1 and P4C1 were significantly inferior in acquiring DA to rats receiving the vehicle or separate administration of P1, P2 or C1. The different treatments with combined or separate administration of P and C had no effect on spontaneous locomotor activity and two-way avoidance conditioning. In a recognition-task only groups C1 and P4 were able to discriminate between familiar and new objects. The combined or separate administration of P1 and C1 on NA, DA, DOPAC, 5-HT, 5-HIAA levels, CAT activity and choline uptake were measured in frontal cortex and hippocampus: the only significant effect was a 5-HT increase in the hippocampus of rats treated with C1.

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Cholinergic modulations and learning

Cited by 2 publications

References 0 publications

Effect of Drugs Acting on Monoaminergic and Cholinergic Systems on the Quantified EEG of Rats

Effect of Drugs Acting on Monoaminergic and Cholinergic Systems on the Quantified EEG of Rats

Effect of combined or separate administration of piracetam and choline on learning and memory in the rat

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