1984
DOI: 10.1210/jcem-59-3-526
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Cholinergic Mediation of Growth Hormone Secretion Elicited by Arginine, Clonidine, and Physical Exercise in Man

Abstract: The role of acetylcholine in human GH secretion was studied with atropine, which selectively blocks cholinergic muscarinic receptors and crosses the blood-brain barrier. Paired tests were performed in 22 normal subjects divided into 4 groups. The stimuli employed were arginine (30 g/30 min, iv), clonidine (300 micrograms, orally), physical exercise for 20 min, and saline. In the second test, atropine (1 mg, im) was administered before GH stimulation. Arginine elicited a GH secretory peak of 16.6 +/- 5 ng/ml (m… Show more

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Cited by 154 publications
(54 citation statements)
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“…However, any additional intervention during the clonidine test would have to be scrutinized prior to implementation in practice, as this intervention in its own may have an effect on the GH axis, thereby rendering this combination unsuitable for a clonidine test. For instance, the combination with atropine would completely suppress GH secretion [22]. Another intervention of interest could be (oral) fluid loading during the procedure.…”
Section: Discussionmentioning
confidence: 99%
“…However, any additional intervention during the clonidine test would have to be scrutinized prior to implementation in practice, as this intervention in its own may have an effect on the GH axis, thereby rendering this combination unsuitable for a clonidine test. For instance, the combination with atropine would completely suppress GH secretion [22]. Another intervention of interest could be (oral) fluid loading during the procedure.…”
Section: Discussionmentioning
confidence: 99%
“…Physical activity promotes GH secretion possibly by a cholinergic mechanism [46]. The relationship between physical activity and IGF-I levels is not consistent in aged people [20,24] and might be influenced by different methodological approaches [24,47].…”
Section: Discussionmentioning
confidence: 99%
“…Pharmacological studies suggest that central muscarinic cholinergic pathways play a role in stimulating GH release in experimental animals and humans (1)(2)(3)(4)(5)(6)(7)(8)(9). The identification of the molecular pathways and the specific muscarinic ACh receptor (mAChR) subtypes involved in mediating these responses should be of considerable potential therapeutic interest.…”
mentioning
confidence: 99%