“…It is already established that most of the drugs, particularly of anticancer, cytostatic, and psychotropic groups, are genotoxic in nature due to their intercalation with DNA, which provokes significant conformational changes in its structural features and directly disrupts the genomic sequence. − In fact, while many flavonoid groups of compounds are known for their antioxidant properties, a number of them are reported to be DNA intercalators also . However, recent experimental studies confirm that several cholinergic drugs, approved by the U.S. Food and Drug Administration (FDA) for the treatment of Alzheimer’s disease (AD), reverse the oxidative stress induced by radicals and also bind at the minor groove of calf-thymus DNA, thus causing no damage to its structural features . The antioxidant property of these AD drugs, coalesced with their harmless association with DNA, presents an alternative way of reversing ROS-mediated DNA stress through a radical scavenging process at the binding locale.…”