Cholinergic basal forebrain is critical for social transmission of food preferences

Effects of nucleus basalis magnocellularis stimulation on a socially transmitted food preference and c-Fos expression

“…Our results are also consistent with others previously reported demonstrating that the cholinergic cells of NBM are involved in acquisition and memory formation of STFP (Berger-Sweeney et al 2000;Vale-Martinez et al 2002). There are indeed more studies suggesting a role of NBM in learning and memory processes.…”

“…Numerous studies propose a well-established role of the NBM, especially its cholinergic cells, in certain attentional processes (Chiba et al 1995;Baxter and Chiba 1999;Gill et al 2000;Himmelheber et al 2001;Sarter et al 2001;McGaughy et al 2002;Lehmann et al 2003). There is also growing evidence that implicates the cholinergic NBM in cognitive functions that may be categorized as mnemonic (Berger-Sweeney et al 2000;Linster et al 2001;Vale-Martinez et al 2002;Bailey et al 2003;Butt et al 2003;Chudasama et al 2004;Ridley et al 2005;Winters and Bussey 2005), supporting findings from initial studies that showed NBM contribution to learning and memory. However, early experiments predominantly evaluated the effects of nonspecific lesions in the NBM, which damaged cholinergic and noncholinergic neurons, on spatial tasks (e.g., Wenk et al 1989;Langlais et al 1993).…”

Effects of nucleus basalis magnocellularis stimulation on a socially transmitted food preference and c-Fos expression

“…Our results are also consistent with others previously reported demonstrating that the cholinergic cells of NBM are involved in acquisition and memory formation of STFP (Berger-Sweeney et al 2000;Vale-Martinez et al 2002). There are indeed more studies suggesting a role of NBM in learning and memory processes.…”

“…Numerous studies propose a well-established role of the NBM, especially its cholinergic cells, in certain attentional processes (Chiba et al 1995;Baxter and Chiba 1999;Gill et al 2000;Himmelheber et al 2001;Sarter et al 2001;McGaughy et al 2002;Lehmann et al 2003). There is also growing evidence that implicates the cholinergic NBM in cognitive functions that may be categorized as mnemonic (Berger-Sweeney et al 2000;Linster et al 2001;Vale-Martinez et al 2002;Bailey et al 2003;Butt et al 2003;Chudasama et al 2004;Ridley et al 2005;Winters and Bussey 2005), supporting findings from initial studies that showed NBM contribution to learning and memory. However, early experiments predominantly evaluated the effects of nonspecific lesions in the NBM, which damaged cholinergic and noncholinergic neurons, on spatial tasks (e.g., Wenk et al 1989;Langlais et al 1993).…”

Transfer Effects and Conditional Learning in Rats With Selective Lesions of Medial Septal/Diagonal Band Cholinergic Neurons.

“…No differences were noted in extent of lesions in rats between the two experiments. Furthermore, these lesions were identical in extent to those in previous studies from our laboratory in which quantitative neurochemical assays have confirmed the extent of cholinergic enzyme depletion from hippocampus as 80% or greater (e.g., Berger-Sweeney et al, 2000; Cahill & Baxter, 2001). Staining for parvalbumin immunoreactive (GABAergic; Freund, 1989) neurons in the MS/VDB was indistinguishable between control (see Figure 2C) and MS/VDB-lesioned (see Figure 2D) rats.…”

Developmental Binge Exposure to Ethanol and Artificial Rearing Do Not Affect the Social Transfer of Diet Preference

“…This finding is also compatible with impaired social recognition after a 60-min interval in male rats exposed prenatally to ethanol (Reid et al, 1999). Delay-dependent deficits on the social-communication task have been noted after lesions to the hippocampal and cholinergic systems, where lesioned rats performed as well as (or better than) controls at short delays but demonstrated reduced preferences at longer time intervals (Alvarez et al, 2001;Berger-Sweeney et al, 2000;Bunsey and Eichenbaum, 1995;Winocur, 1990;cf Burton et al, 2000). Given findings of both hippocampal and cholinergic dysfunction after early postnatal binge exposure to ethanol (Berman and Hannigan, 2000;Bonthius et al, 2001;Kelly et al, 1989;West and Hamre, 1985) and our findings of delay-dependent deficits in the water maze (Girard et al, 2000), it was expected that ET rats would show reduced preferences for the communicated diet after 24-hr and 4-week retention intervals.…”

Effects of nucleus basalis magnocellularis stimulation on a socially transmitted food preference and c-Fos expression

“…Our results are also consistent with others previously reported demonstrating that the cholinergic cells of NBM are involved in acquisition and memory formation of STFP (Berger-Sweeney et al 2000;Vale-Martinez et al 2002). There are indeed more studies suggesting a role of NBM in learning and memory processes.…”

“…Numerous studies propose a well-established role of the NBM, especially its cholinergic cells, in certain attentional processes (Chiba et al 1995;Baxter and Chiba 1999;Gill et al 2000;Himmelheber et al 2001;Sarter et al 2001;McGaughy et al 2002;Lehmann et al 2003). There is also growing evidence that implicates the cholinergic NBM in cognitive functions that may be categorized as mnemonic (Berger-Sweeney et al 2000;Linster et al 2001;Vale-Martinez et al 2002;Bailey et al 2003;Butt et al 2003;Chudasama et al 2004;Ridley et al 2005;Winters and Bussey 2005), supporting findings from initial studies that showed NBM contribution to learning and memory. However, early experiments predominantly evaluated the effects of nonspecific lesions in the NBM, which damaged cholinergic and noncholinergic neurons, on spatial tasks (e.g., Wenk et al 1989;Langlais et al 1993).…”

Transfer Effects and Conditional Learning in Rats With Selective Lesions of Medial Septal/Diagonal Band Cholinergic Neurons.

“…No differences were noted in extent of lesions in rats between the two experiments. Furthermore, these lesions were identical in extent to those in previous studies from our laboratory in which quantitative neurochemical assays have confirmed the extent of cholinergic enzyme depletion from hippocampus as 80% or greater (e.g., Berger-Sweeney et al, 2000; Cahill & Baxter, 2001). Staining for parvalbumin immunoreactive (GABAergic; Freund, 1989) neurons in the MS/VDB was indistinguishable between control (see Figure 2C) and MS/VDB-lesioned (see Figure 2D) rats.…”

Developmental Binge Exposure to Ethanol and Artificial Rearing Do Not Affect the Social Transfer of Diet Preference

“…This finding is also compatible with impaired social recognition after a 60-min interval in male rats exposed prenatally to ethanol (Reid et al, 1999). Delay-dependent deficits on the social-communication task have been noted after lesions to the hippocampal and cholinergic systems, where lesioned rats performed as well as (or better than) controls at short delays but demonstrated reduced preferences at longer time intervals (Alvarez et al, 2001;Berger-Sweeney et al, 2000;Bunsey and Eichenbaum, 1995;Winocur, 1990;cf Burton et al, 2000). Given findings of both hippocampal and cholinergic dysfunction after early postnatal binge exposure to ethanol (Berman and Hannigan, 2000;Bonthius et al, 2001;Kelly et al, 1989;West and Hamre, 1985) and our findings of delay-dependent deficits in the water maze (Girard et al, 2000), it was expected that ET rats would show reduced preferences for the communicated diet after 24-hr and 4-week retention intervals.…”

Effects of nucleus basalis magnocellularis stimulation on a socially transmitted food preference and c-Fos expression

“…Our results are also consistent with others previously reported demonstrating that the cholinergic cells of NBM are involved in acquisition and memory formation of STFP (Berger-Sweeney et al 2000;Vale-Martinez et al 2002). There are indeed more studies suggesting a role of NBM in learning and memory processes.…”

“…Numerous studies propose a well-established role of the NBM, especially its cholinergic cells, in certain attentional processes (Chiba et al 1995;Baxter and Chiba 1999;Gill et al 2000;Himmelheber et al 2001;Sarter et al 2001;McGaughy et al 2002;Lehmann et al 2003). There is also growing evidence that implicates the cholinergic NBM in cognitive functions that may be categorized as mnemonic (Berger-Sweeney et al 2000;Linster et al 2001;Vale-Martinez et al 2002;Bailey et al 2003;Butt et al 2003;Chudasama et al 2004;Ridley et al 2005;Winters and Bussey 2005), supporting findings from initial studies that showed NBM contribution to learning and memory. However, early experiments predominantly evaluated the effects of nonspecific lesions in the NBM, which damaged cholinergic and noncholinergic neurons, on spatial tasks (e.g., Wenk et al 1989;Langlais et al 1993).…”

Transfer Effects and Conditional Learning in Rats With Selective Lesions of Medial Septal/Diagonal Band Cholinergic Neurons.

“…No differences were noted in extent of lesions in rats between the two experiments. Furthermore, these lesions were identical in extent to those in previous studies from our laboratory in which quantitative neurochemical assays have confirmed the extent of cholinergic enzyme depletion from hippocampus as 80% or greater (e.g., Berger-Sweeney et al, 2000; Cahill & Baxter, 2001). Staining for parvalbumin immunoreactive (GABAergic; Freund, 1989) neurons in the MS/VDB was indistinguishable between control (see Figure 2C) and MS/VDB-lesioned (see Figure 2D) rats.…”

Developmental Binge Exposure to Ethanol and Artificial Rearing Do Not Affect the Social Transfer of Diet Preference

“…This finding is also compatible with impaired social recognition after a 60-min interval in male rats exposed prenatally to ethanol (Reid et al, 1999). Delay-dependent deficits on the social-communication task have been noted after lesions to the hippocampal and cholinergic systems, where lesioned rats performed as well as (or better than) controls at short delays but demonstrated reduced preferences at longer time intervals (Alvarez et al, 2001;Berger-Sweeney et al, 2000;Bunsey and Eichenbaum, 1995;Winocur, 1990;cf Burton et al, 2000). Given findings of both hippocampal and cholinergic dysfunction after early postnatal binge exposure to ethanol (Berman and Hannigan, 2000;Bonthius et al, 2001;Kelly et al, 1989;West and Hamre, 1985) and our findings of delay-dependent deficits in the water maze (Girard et al, 2000), it was expected that ET rats would show reduced preferences for the communicated diet after 24-hr and 4-week retention intervals.…”