Cholinergic and catecholaminergic interaction and fluid intake in the rat

Schmidt, Péter; Zámbó, Katalin; Decsi, L; Nagy, Júlia

doi:10.1016/0014-2999(81)90342-3

Cited by 4 publications

(2 citation statements)

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“…Singer and Kelly (1972) reported that the injection of norepinephrine into the rat hypothalamus reduces fluid intake. Intrapreoptic application of noradrenaline inhibited carbachol-induced polydipsia in rats (Schmidt et al 1981). This same injection inhibited angiotensin II-induced drinking behavior, suggesting an interaction between the adrenergic and renin-angiotensin systems (Fitzsimons and Setler 1974;Morley 1987).…”

Section: Introductionmentioning

confidence: 95%

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Involvement of the α 2 -adrenergic system in polydipsia in schizophrenic patients: a pilot study

et al. 1997

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Animal studies have suggested the involvement of the adrenergic system in drinking behavior. The present study investigated the involvement of the alpha2-adrenergic system in the polydipsia of patients with chronic schizophrenia by use of an alpha2 agonist and an antagonist. Four patients with schizophrenic disorders accompanied by intermittent hyponatremia and polydipsia were the subjects of, and completed, this study. Drinking behavior was assessed by calculating the percent of maximum weight gain [PMWG: (maximum diurnal weight - standard weight) x 100/standard weight]. Standard weight was defined as body weight after 8 h of water restriction. Clonidine (75, 150, and 225 mg/day) increased the PMWG in a dose-dependent manner in the four subjects. In contrast, in three of the subjects, mianserin (30, 60, and 90 mg/day) decreased PMWG, and the severe polydipsia disappeared almost completely. These findings indicate clearly that the alpha2-adrenergic system is involved in the drinking behavior of schizophrenic patients. Mianserin appears to be clinically useful in treating such patients with polydipsia.

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Section: Introductionmentioning

confidence: 95%

“…Adrenergic neurons reportedly modulate drinking behavior in animals (Singer and Kelly 1972;Fitzsimons and Setler 1974;Schmidt et al 1981). Norepinephrine is a potent antidipsogenic, reducing the drinking behavior produced in the rat by carbachol, angiotensin II, hypertonic saline, and polyethylene glycol (Grossman 1962;Morley 1987).…”

Section: Introductionmentioning

confidence: 97%