Choline Protects the Heart from Doxorubicin-Induced Cardiotoxicity through Vagal Activation and Nrf2/HO-1 Pathway

Guo, Feng-Biao; Wang, Yueyi; Wang, Jun; Liu, Zhihao; Lai, Yanqiu; Zhou, Zhen; Liu, Zihan; Zhou, Yuyang; Xu, Xiaohong; Li, Zeyan; Wang, Meng; Yu, Fu; Hu, Ran; Zhou, Liping; Jiang, Hong

doi:10.1155/2022/4740931

Cited by 11 publications

(8 citation statements)

References 55 publications

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“…Choline plays a protective role in the heart and may be a promising candidate to improve doxorubicin-induced cardiotoxicity via vagal activity and Nrf2/HO-1 pathway ( 121 ). Moreover, choline exhibits protective effects against cardiovascular disorders, including arrhythmias, cardiac hypertrophy, and ischemia/reperfusion (I/R)-induced vascular injury by inhibiting the ROS-mediated Ca 2+ /calmodulin-dependent protein kinase II pathway ( 122 – 124 ).…”

Section: Choline Supplementation and Cardio-metabolic Disordersmentioning

confidence: 99%

Choline supplements: An update

Kansakar

Trimarco²,

Mone³

et al. 2023

Front. Endocrinol.

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In this comprehensive review, we examine the main preclinical and clinical investigations assessing the effects of different forms of choline supplementation currently available, including choline alfoscerate (C8H20NO6P), also known as alpha-glycerophosphocholine (α-GPC, or GPC), choline bitartrate, lecithin, and citicoline, which are cholinergic compounds and precursors of acetylcholine. Extensively used as food supplements, they have been shown to represent an effective strategy for boosting memory and enhancing cognitive function.

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Section: Choline Supplementation and Cardio-metabolic Disordersmentioning

confidence: 99%

Choline supplements: An update

Kansakar

Trimarco²,

Mone³

et al. 2023

Front. Endocrinol.

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“…Modulation of Cellular Apoptosis. Statistics from laboratory investigations endorse the notion that cellular senescence and programmed apoptosis are crucial for an organism to sustain internal homeostasis; yet, excessive apoptosis of ECs and cardiomyocytes have been intimately related to the pathogenesis of CVDs [80,81,142]. In detail, ECs, forming the lining of blood vessels, produce and release diverse active mediators to maintain vasculature tension and integrity, regulate platelet adhesion, balance oxidative stress, and prohibit inflammation response.…”

Section: Suppression Of Platelet Activation and Aggregationmentioning

confidence: 99%

The Therapeutic Roles of Cinnamaldehyde against Cardiovascular Diseases

Lü

Xiong

Zhou

et al. 2022

Oxidative Medicine and Cellular Longevity

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Evidence from epidemiological studies has demonstrated that the incidence and mortality of cardiovascular diseases (CVDs) increase year by year, which pose a great threat on social economy and human health worldwide. Due to limited therapeutic benefits and associated adverse effects of current medications, there is an urgent need to uncover novel agents with favorable safety and efficacy. Cinnamaldehyde (CA) is a bioactive phytochemical isolated from the stem bark of Chinese herbal medicine Cinnamon and has been suggested to possess curative roles against the development of CVDs. This integrated review intends to summarize the physicochemical and pharmacokinetic features of CA and discuss the recent advances in underlying mechanisms and potential targets responsible for anti-CVD properties of CA. The CA-related cardiovascular protective mechanisms could be attributed to the inhibition of inflammation and oxidative stress, improvement of lipid and glucose metabolism, regulation of cell proliferation and apoptosis, suppression of cardiac fibrosis, and platelet aggregation and promotion of vasodilation and angiogenesis. Furthermore, CA is likely to inhibit CVD progression via affecting other possible processes including autophagy and ER stress regulation, gut microbiota and immune homeostasis, ion metabolism, ncRNA expression, and TRPA1 activation. Collectively, experiments reported previously highlight the therapeutic effects of CA and clinical trials are advocated to offer scientific basis for the compound future applied in clinical practice for CVD prophylaxis and treatment.

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“…Activation of Nrf2 pathway has a protective effect inflammation and OS [ 33 ]. To further determine the role of Nrf2 in the effects of hesperetin, we examined the protein levels of Nrf2 in VICs.…”

Section: Resultsmentioning

confidence: 99%

Hesperetin, a Promising Dietary Supplement for Preventing the Development of Calcific Aortic Valve Disease

et al. 2022

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Background: No effective therapeutic agents for calcific aortic valve disease (CAVD) are available currently. Dietary therapy has been proposed as a novel treatment strategy for various diseases. As a flavanone, hesperetin is widely abundant in citrus fruits and has been proven to play a protective role against multiple diseases. However, the role of hesperetin in CAVD remains unclear. Methods: Human aortic valve interstitial cells (VICs) were isolated from aortic valve leaflets. A mouse model of aortic valve stenosis was constructed through direct wire injury (DWI). Immunoblotting, immunofluorescence staining, and flow cytometry were used to investigate the roles of sirtuin 7 (Sirt7) and nuclear factor erythroid 2-related factor 2 (Nrf2) in hesperetin-mediated protective effects in VICs. Results: Hesperetin supplementation protected the mice from wire-injury-induced aortic valve stenosis; in vitro, hesperetin suppressed the lipopolysaccharide (LPS)-induced activation of NF-κB inflammatory cytokine secretion and osteogenic factors expression, reduced ROS production and apoptosis, and abrogated LPS-mediated injury to the mitochondrial membrane potential and the decline in the antioxidant levels in VICs. These benefits of hesperetin may have been obtained by activating Nrf2–ARE signaling, which corrected the dysfunctional mitochondria. Furthermore, we found that hesperetin could directly bind to Sirt7 and that the silencing of Sirt7 decreased the effects of hesperetin in VICs and potently abolished the ability of hesperetin to increase Nrf2 transcriptional activation. Conclusions: Our work demonstrates that hesperetin plays protective roles in the aortic valve through the Sirt7–Nrf2–ARE axis; thus, hesperetin might be a potential dietary supplement that could prevent the development of CAVD.

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Choline Protects the Heart from Doxorubicin-Induced Cardiotoxicity through Vagal Activation and Nrf2/HO-1 Pathway

Cited by 11 publications

References 55 publications

Choline supplements: An update

Choline supplements: An update

The Therapeutic Roles of Cinnamaldehyde against Cardiovascular Diseases

Hesperetin, a Promising Dietary Supplement for Preventing the Development of Calcific Aortic Valve Disease

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