Choline kinase beta is required for normal endochondral bone formation

Li, Zhuo; Wu, Gengshu; Sher, Roger B.; Khavandgar, Zohreh; Hermansson, Martin; Cox, Gregory A.; Doschak, Michael R.; Murshed, Monzur; Beier, Frank; Vance, Dennis E.

doi:10.1016/j.bbagen.2014.03.008

Cited by 25 publications

(25 citation statements)

References 80 publications

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“…Loss of CHKB corresponds to a hind limb muscular dystrophy and forelimb deformity due to decreased levels of phosphatidylcholine (16,41). A recent study has established that the forelimb deformity in CHKB-deficient mice is due to altered growth plate physiology in the embryo, implicating a role for CHKB in endochondral bone formation (42). Homozygous and compound heterozygous mutations in CHKB have been identified in patients with congenital muscular dystrophy (17)(18)(19)43).…”

Section: Discussionmentioning

confidence: 99%

Choline Kinase β Mutant Mice Exhibit Reduced Phosphocholine, Elevated Osteoclast Activity, and Low Bone Mass

Kular¹,

Tickner²,

Pavlos

et al. 2015

Journal of Biological Chemistry

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Background: Bone homeostasis requires constant remodeling by bone-resorbing osteoclasts and bone-forming osteoblasts. Results: Choline kinase ␤ (CHKB)-deficient mice have reduced bone mass, increased osteoclast number, and impaired osteoblast function. Conclusion: CHKB activity controls bone homeostasis via regulation of osteoclasts and osteoblasts. Significance: This is the first report implicating a role for CHKB in bone homeostasis.

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Section: Discussionmentioning

confidence: 99%

Choline Kinase β Mutant Mice Exhibit Reduced Phosphocholine, Elevated Osteoclast Activity, and Low Bone Mass

Kular¹,

Tickner²,

Pavlos

et al. 2015

Journal of Biological Chemistry

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“…The reason for perosis caused by choline deficiency may be that the content of phosphatidylcholine in the bone cell was decreased, because choline is a component of the membrane phospholipids (Hollenbeck, 2010). Additionally, choline deficiency could cause a decrease in choline kinase activity (Li et al, 2005); previous study has shown that choline kinase was required for normal endochondral bone formation (Li et al, 2014). …”

Section: Resultsmentioning

confidence: 99%

Effects of Dietary Methionine Levels on Choline Requirements of Starter White Pekin Ducks

Wen

Tang

Xie

et al. 2016

Asian Australas. J. Anim. Sci

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A 2×5 factorial experiment, using 2 dietary methionine levels (0.28% and 0.48%) and 5 dietary choline levels (0, 394, 823, 1,239, and 1,743 mg/kg), was conducted to study the effects of dietary methionine status on choline requirements of starter white Pekin ducks from 7 to 28 days of age. Four hundred eighty 7-d-old male White Pekin ducks were randomly allotted to ten dietary treatments, each containing 6 replicate pens with 8 birds per pen. At 28 d of age, weight gain, feed intake, and feed/gain were measured and the legs of all ducks from each pen were examined for incidence of perosis. Perosis and growth depression were observed in choline-deficient ducks and supplementation of choline reduced perosis and significantly increased weight gain and feed intake regardless of dietary methionine levels (p<0.05). In addition, significant positive effects of dietary methionine supplementation on weight gain, feed intake, and feed/gain were observed at any choline level (p<0.05). Supplementation of 1,743 mg/kg choline in diets alleviated the depression of weight gain and feed intake caused by methionine deficiency at 0.28% methionine level. The interaction between choline and methionine influenced weight gain and feed intake of ducks (p<0.05). At 0.28% methionine level, 1,743 mg/kg choline group caused 4.92% and 3.23% amount of improvement in weight gain and feed intake compared with 1,239 mg/kg choline group, respectively. According to the broken-line regression, the choline requirements of starter Pekin ducks for weight gain and feed intake were 1,472 and 1,424 mg/kg at 0.28% methionine level and 946 and 907 mg/kg at 0.48% methionine level, respectively. It suggested the choline recommendations of starter Pekin ducks on a semi-purified diet were 1448 mg/kg at 0.28% methionine level and 927 mg/kg at 0.48% methionine level, respectively. Compared with the adequate methionine level, menthionine deficiency markedly increased the choline requirements of ducks.

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“…Several evidence underlines the importance of phosphocholine in bone mineralization [126]; however, at present no experimental data directly links Cer or choline to Extracellular matrix (ECM) mineralization. Studies in animal models are in some way in conflict with studies performed in cell culture: the inhibition of nSMase2/SMPD3 by GW4869 accelerates the mineralization of chondrogenic ATDC5 cultures [127], whereas either the fro/fro mice or mice lacking choline kinase presents an expansion of hypertrophic zone likely due to a delay in apoptosis of hypertrophic chondrocytes [128]. The role of Cer in bone tissue has been examined by other approaches leading also to conflicting results, such as short-chain synthetic cell-permeable forms of Cer, preferentially C-2 Cer [129].…”

Section: C1p-ceramidementioning

confidence: 86%

Vitamin D and Sphingolipids: Role in Bone and Neural System

Frati¹,

Gil²,

Pierucci³

et al. 2017

A Critical Evaluation of Vitamin D - Basic Overview

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Abstract1-Alpha,25-dihydroxyvitamin D3 (1,25(OH) 2 D 3 ) is known to play an important physiological role on growth and differentiation in a variety of nonmalignant and malignant cell types through classical actions, mediated by its specific receptor (VDR), and nongenomic actions resulting in the activation of specific signalling pathways. Due to the broad distribution of Vitamin D Receptor (VDR) in many tissues and the ability of 1,25(OH) 2 D 3 to regulate fundamental processes, such as cell proliferation and differentiation, this steroid hormone has been suggested in the treatment of different diseases, from cancer to neurodegenerative diseases. In fact, structural 1,25(OH) 2 D 3 analogues, with weaker collateral effects, have recently entered in clinical trials. Other interesting molecules due to their pleiotropic actions are the bioactive sphingolipids (SLs), in particular ceramide (Cer) and sphingosine 1-phosphate (S1P). Cells maintain a dynamic balance of these metabolites since Cer and sphingoid bases mediate cell death, while S1P exerts mitogenic effects and promotes differentiation of several cell types including osteogenic and neural cells. The biological actions of 1,25(OH) 2 D 3 and SLs, in particular S1P, share many common effectors, including calcium regulation, growth factor expression, inflammatory cytokines, etc., but whether they could act synergistically is still unknown and deserves further investigation.

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Choline kinase beta is required for normal endochondral bone formation

Cited by 25 publications

References 80 publications

Choline Kinase β Mutant Mice Exhibit Reduced Phosphocholine, Elevated Osteoclast Activity, and Low Bone Mass

Choline Kinase β Mutant Mice Exhibit Reduced Phosphocholine, Elevated Osteoclast Activity, and Low Bone Mass

Effects of Dietary Methionine Levels on Choline Requirements of Starter White Pekin Ducks

Vitamin D and Sphingolipids: Role in Bone and Neural System

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