Choline elevation in amygdala region at recovery indicates longer survival without depressive episode: a magnetic resonance spectroscopy study

Henigsberg, Neven; Savić, Aleksandar; Radoš, Marko; Šarac, Helena; Šečić, Ana; Janović, Maja Bajs; Foro, Tamara; Ozretić, David; Turk, Viktorija Erdeljić; Hrabač, Pero; Kalember, Petra

doi:10.1007/s00213-019-05303-2

Cited by 4 publications

(3 citation statements)

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“…The Cho is a marker to detect the turnover of glial cell membrane in CNS and is also an essential precursor of acetylcholine and membrane lipids, phosphatidylcholine, and sphingomyelin [ 19 – 22 ]. The reduction of tCho/tCr levels in the ACC of JIA was consistent with previously reported alterations in the brain phospholipid metabolism, which may lead to altered lipid membrane turnover and neuroplasticity [ 23 , 24 ]. The decreased tCho/tCr ratio also supported the impaired astrocytic functioning and altered neuroplasticity in JIA patients.…”

Section: Discussionsupporting

confidence: 91%

Evidence of persistent glial cell dysfunction in the anterior cingulate cortex of juvenile idiopathic arthritis children: a proton MRS study

et al. 2022

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Background This study aims to investigate whether the neurometabolites of the anterior cingulate cortex (ACC) were distinct in patients with active and inactive juvenile idiopathic arthritis (JIA) using the proton magnetic resonance spectroscopy. Methods We measured the levels of total N-acetylaspartate (tNAA), choline (Cho), myo-inositol (ml), glutamate (Glu) and the complex of glutamate and glutamine (Glx) relative to total creatine (tCr) in ACC of each participant. Results Compared with the healthy controls, a significant decrease of total Cho/tCr and Glx/tCr ratio in ACC occurred in active and inactive JIA group. The tCho/Cr level was negatively associated with the serum level of ESR in active JIA patients. There was no difference in NAA/tCr ratio among the three groups, which may imply that no neuron and axonal losses occurred in either active or inactive JIA patients. Conclusions The abnormal neurometabolites in tCho/tCr and Glx/tCr in ACC may indicate that persistent dysfunction of glial cell, while neither neuron nor axonal losses occurred in active and inactive JIA patients.

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Section: Discussionsupporting

confidence: 91%

Evidence of persistent glial cell dysfunction in the anterior cingulate cortex of juvenile idiopathic arthritis children: a proton MRS study

et al. 2022

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“…Choline pathway nutrients, including choline and betaine, could ameliorate neurological impairment, increase neuroplasticity, and promote recovery after stroke [8–10]. It has been reported that subjects with major depressive disorder had lower urinary choline levels [11], and higher choline levels were observed in the amygdala region of patients with a lower risk of depression recurrence [12]. Moreover, previous animal studies demonstrated that supplemental choline or betaine in rats model could reverse early life‐induced depression and produce substantive antidepressant‐like effects [13,14].…”

Section: Introductionmentioning

confidence: 99%

Circulating choline pathway nutrients and depression after ischemic stroke

Miao

Che

et al. 2021

Euro J of Neurology

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Background and purpose Choline pathway nutrients, including choline and betaine, are reported to exert antidepressant effects. However, there is little population‐based evidence on the relationships between circulating choline and betaine and poststroke depression (PSD). We aimed to prospectively explore the associations between plasma choline and betaine and depression after ischemic stroke. Methods This study was based on the China Antihypertensive Trial in Acute Ischemic Stroke. A total of 612 participants with plasma choline and betaine concentrations were included in the analysis. The study outcome was depression 3 months after ischemic stroke. Logistic regression models were performed to estimate the relationships between plasma choline and betaine and the risk of PSD. Risk reclassification and calibration of models with choline or betaine were analyzed. Results Patients with PSD had lower choline and betaine levels than those without PSD (p < 0.05). Compared with tertile 1, the multivariable‐adjusted odds ratios (95% CIs) for tertile 3 of choline and betaine were 0.54 (0.35–0.83) and 0.59 (0.38–0.92), respectively. Per 1 SD increase in choline or betaine was associated with a 25% (95% CI 9%–37%) or an 19% (95% CI 3%–32%) decreased risk of PSD, respectively. Furthermore, the addition of choline or betaine to the established risk factors model improved the risk reclassification for PSD, as shown by an increase in the net reclassification index and integrated discrimination improvement (all p < 0.05). Conclusions Patients with elevated levels of choline and betaine had a lower risk of depression after acute ischemic stroke, suggesting the protective significance of choline pathway nutrients for PSD.

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“…Alice Egerton reviews the use of another neurochemical imaging approach, magnetic resonance spectroscopy, for drug development, highlighting its potential but also a number of issues that need to be resolved (Egerton 2021). Several studies test mechanism of action of drugs to inform the development of these drugs or treatment approaches generally (Nathan & Bakker 2021;Grimm et al 2021;Gilleen et al 2021) and, potentially, also of a biomarker to predict recovery following treatment (Henigsberg et al 2021). The special issue also includes reviews that draw on evidence from imaging studies to consider models of antidepressant action and how to improve personalized treatment prediction (Paulus & Thompson 2021;Godlewska & Harmer 2021).…”

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confidence: 99%