Choline and halogen derivatives of CMA (9-oxo-10-acridine acetic acids) as tools for monitoring the interaction of the interferon inducers via a specific receptor

Synthesis of carbocyclic derivatives of 9 (10 H)‐acridinone, 9H‐carbazole and 10 H‐phenothiazine 5,5‐dioxide as potential immunomodulating agents

“…The last extensive experiments performed with sodium salt of 9-0x0-10-acridineacetic aoid (CMA, (I)), one of the simplest but very potent anionic IB" inducer, gave support of the hypothesis that the induction of I F N by CMA is a receptor mediated event [3-71. It is noteworthy that some of close as well as distant analogs of CMA, which acted as its enhancers (e. g. 2 [4], carprofen and indomethacin [S]) or inhibitors (3) [7]), possess the free N-carboxymethyl group.The aim of this work was the synthesis of novel CMA analogs with structural modifications concerning three moieties of the parent molecule 1 as is shown in the Scheme 1.r ------------7…”