Choline amino acid ionic Liquids: A novel green potential lubricant

Li, Yuting; Yang, Fan; Li, Yuan; Cai, Meiling; Li, Hao; Fan, Xiaoqiang; Zhu, Minhao

doi:10.1016/j.molliq.2022.119539

Cited by 14 publications

(7 citation statements)

References 37 publications

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“…They confirmed this IL using the Fourier transform infrared (FT-IR) spectra and nuclear magnetic resonance (NMR) spectroscopy. We synthesized the novel ILs successfully and characterized them using FT-IR and NMR spectra ( 38 ). The other researcher applied a series of 1-alkylquinolinium bromide against clinically relevant microbes such as C. albicans .…”

Section: Discussionmentioning

confidence: 99%

Effect of new methionine-based ionic liquid on the CDR1 and CDR2 gene expression on sensitive and resistant strains of Candida albicans

Eslami

Ezabadi

Bayat

et al. 2023

IJM

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Background and Objectives: Previous researchers showed the antimicrobial ability of ionic liquids (ILs) on different infec- tive agents. ILs can dissolve organic components, especially DNA molecules. Among synthesized eight binary ILs mixtures, we have chosen ([Met-HCl] [PyS]) IL for determining the antifungal ability of IL against Candida albicans cells. Materials and Methods: Well diffusion assay, chrome agar and Germ tube tests were used to detect the Candida samples. PCR, real-time-PCR, and flow cytometry tests were performed to determine the IL's rate of toxic ability. Results: Well diffusion assay revealed the diameters of the growth inhibition zones were the largest in IL with methionine and Proline amino acids. Minimum inhibitory concentration (MIC) and the Minimum fungicidal concentration (MFC) tests showed that they inhibited the growth of the C. albicans at a range from 250 µg/ml for sensitivity and 400 µg/ml for resis- tance, MIC average of all samples were 341.62 ± 4.153 µg/ml. IL reduced the expression of CDR1 and CDR2 the genes encoded by the major protein of ABC system transporter by 2.1 (P= 0.009) and 1.2 fold (P= 0.693), revealed by PCR and real time-PCR. In the flow cytometry test, there were increasing dead cells after treating with the ([Met-HCl] [PyS]) even in the most resistant strain. Conclusion: The novel IL was effective against the most clinical and standard C. albicans.

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Section: Discussionmentioning

confidence: 99%

Effect of new methionine-based ionic liquid on the CDR1 and CDR2 gene expression on sensitive and resistant strains of Candida albicans

Eslami

Ezabadi

Bayat

et al. 2023

IJM

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Section: Introductionmentioning

confidence: 99%

“…31,32 Other properties of [Cho][AA], viscosity in particular, vary significantly, and, remarkably, some derivatives exhibit lubrication performance comparable to that found for olefin oils. 37 In an attempt to explore further the synthetic ability of [Cho][AA], we document our pursuits in the aza-Michael reaction, which has been described under a wide variety of conditions as already mentioned, 1,2 and provide insights into the catalytic performance of these neoteric liquids.…”

Section: Introductionmentioning

confidence: 99%

Reinvigorating aza-Michael reactions under ionic liquid catalysis: a greener approach

Izquierdo,

Cintas,

Durán-Valle

et al. 2024

Org. Biomol. Chem.

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“…20 CAAILs are seen as the most promising and secure ILs since they present lower toxicity, higher biocompatibility, and higher biodegradability, as well as more abundant raw materials. 21 In literature, the extraction of amoxicillin in ATPSs was mainly carried out using polymers such as poly(ethylene glycol) (PEG) with 1500 22 and 6000 23 g•mol −1 , inorganic salts such as K 2 HPO 4 23 and Li 2 SO 4 , 22 and organic salts such as Na 2 C 4 H 4 O 6 (disodium tartrate) 22 and Na 3 C 6 H 5 O 7 (trisodium citrate). 22 Nevertheless, no studies are known involving the application of CAAILs in the removal of this API.…”

Section: Introductionmentioning

confidence: 99%

“…, imidazolium and pyridinium) and anions (often fluorine-based) show scarce biodegradability and biocompatibility. , Therefore, ILs based on amino acids and choline, which are nontoxic and biodegradable, were developed, which are known as choline-amino acid ([Ch][AA]) ILs [or choline-amino acid ILs (CAAILs)] . CAAILs are seen as the most promising and secure ILs since they present lower toxicity, higher biocompatibility, and higher biodegradability, as well as more abundant raw materials …”

Section: Introductionmentioning

confidence: 99%

Water Purification Using Choline-Amino Acid Ionic Liquids: Removal of Amoxicillin

Velho,

Lopes,

Macedo

2024

Ind. Eng. Chem. Res.

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Antibiotics are the main active pharmaceutical ingredients (APIs) for the treatment and prevention (prophylaxis) of bacterial infections, for which they are essential for health preservation. However, depending on the target bacterial strain, an efficient treatment may imply weeks of continuous intake of antibiotics, whose unmetabolized fraction ends up in the wastewater system by human and animal excreta. The presence of these chemical compounds in wastewater is known to damage aquatic ecosystems and cause antibiotic resistance of pathogenic agents, which threatens the future application of these medicines. Aqueous two-phase systems (ATPSs), an emergent extraction technology for biomolecules such as proteins and vitamins, could provide more eco-friendly and cost-effective extractive alternatives given their nontoxicity and low energetic requirements. Moreover, choline-amino acid ([Ch][AA]) ionic liquids (also known as CAAILs or ChAAILs) are considered one of the greenest classes of ionic liquids due to their favorable biocompatibility, biodegradability, and ease of chemical synthesis. In this work, partition studies of amoxicillin were performed in three ATPSs containing dipotassium hydrogen phosphate (K2HPO4) and the CAAILs (cholinium l-alaninate, [Ch][Ala]; cholinium glycinate, [Ch][Gly]; and cholinium serinate, [Ch][Ser]) at 298.15 K and 0.1 MPa. To better characterize the extract and reduce errors in quantification, the effect of pH on the intensity and stability of the UV–vis spectra of amoxicillin was studied prior to the partition studies, and computational chemistry was used to validate the molecular structure of the synthesized ionic liquids. During experimental determinations, it was observed that the extraction of amoxicillin was favored by less polar ionic liquids, achieving maximum partition coefficients (K) and extraction efficiencies (E) of K = (16 ± 6)·101 and E / % = 97 ± 2, respectively, for {[Ch][Gly] (1) + K2HPO4 (2) + Water (3)} in the longest tie-line.

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Choline amino acid ionic Liquids: A novel green potential lubricant

Cited by 14 publications

References 37 publications

Effect of new methionine-based ionic liquid on the CDR1 and CDR2 gene expression on sensitive and resistant strains of Candida albicans

Effect of new methionine-based ionic liquid on the CDR1 and CDR2 gene expression on sensitive and resistant strains of Candida albicans

Reinvigorating aza-Michael reactions under ionic liquid catalysis: a greener approach

Water Purification Using Choline-Amino Acid Ionic Liquids: Removal of Amoxicillin

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