Cholic acid functionalized star poly(DL-lactide) for promoting cell adhesion and proliferation

Zhao

J of Applied Polymer Sci

et al. 2010

Myosin XVA is an unconventional myosin which has been implicated in autosomal recessive nonsyndromic hearing impairment (ARNSHI) in humans. In Myo15A mouse models, vestibular dysfunction accompanies the autosomal recessive hearing loss. Genomewide homozygosity mapping and subsequent fine mapping in two Turkish families with ARNSHI revealed significant linkage to a critical interval harboring a known deafness gene MYO15A on chromosome 17p13.1‐17q11.2. Subsequent sequencing of the MYO15A gene led to the identification of a novel missense mutation, c.5492G → T (p.Gly1831Val) and a novel splice site mutation, c.8968 − 1G → C. These mutations were not detected in additional 64 unrelated ARNSHI index patients and in 230 Turkish control chromosomes. Gly1831 is a conserved residue located in the motor domains of the different classes of myosins of different species. Molecular modeling of the motor head domain of the human myosin XVa protein suggests that the Gly1831Val mutation inhibits the powerstroke by reducing backbone flexibility and weakening the hydrophobic interactions necessary for signal transmission to the converter domain. © 2007 Wiley‐Liss, Inc.

Section: Discussionmentioning

confidence: 99%

Section: Gpc Characterization Of Poly(dl-lactide-cholate)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Synthesis of poly(D,L‐lactic acid) modified by cholic acid via direct melt copolycondensation and its characterization

Zhao

J of Applied Polymer Sci

et al. 2010

The Journal of Gene Medicine

“…According to our previous studies, CA‐(DLL) n has an accelerated degradation rate because of its branched structure compared to conventional linear poly( DL ‐lactide) (PDLLA), and the degradation of CA‐(DLL) n is dominated by surface erosion mechanism when its molecular weight is not very high 17. Moreover, compared to PDLLA, CA‐(DLL) n has a better performance in promoting cell attachment and growth 19. For comparison, we also investigated the film‐mediated transfection using conventional linear PDLLA as the matrix.…”

Section: Resultsmentioning

confidence: 99%

Dendrimer/DNA complexes encapsulated functional biodegradable polymer for substrate‐mediated gene delivery

Fu¹,

Cheng²,

Zhang³

et al. 2008

Self Cite

Sci. China Ser. B-Chem.

“…A series of star-shaped polymers were prepared with cholic acid as the core and DL-lactide, ε-caprolactone or other carbonates as branches through ring-opening polymerization by the group of Zhuo (Figure 8, A-D). These polymers can be useful in applications such as drug release [38][39][40][41][42] and gene delivery [43] , and can serve as scaffolds to promote cell attachment and growth [44,45] . When thermo-sensitive groups were attached onto position 24 of cholic acid, ringopening polymerization yielded thermo-sensitive drug carriers [46] .…”

Section: Bile Acids As the Core Of Star-shaped Polymersmentioning

confidence: 99%

Biomaterials made of bile acids

Zhang

Zhu

2009

The use of natural compounds in the preparation of new materials can improve the biocompatibility of the materials and avoid any potential toxicity of the degradation products when used for biomedical applications. Bile acids are amphiphilic molecules biosynthesized in the liver. They are used to prepare various polymers and oligomers. These polymers made of bile acids are promising materials in both biomedical and pharmaceutical fields.