Cholesteryl esters in human malignant neoplasms

Signaling through cholesterol esterification: a new pathway for the cholecystokinin 2 receptor involved in cell growth and invasion

“…In line with these studies, increased levels of cholesteryl esters in glioma tissues and in surrounding infi ltrated areas of human brain have been reported compared with normal material while cholesterol was signifi cantly lower in tumor tissue ( 43 ), suggesting a possible involvement of cholesteryl esters in the development and progression of these tumors that remain untreatable. In addition, important amounts of cholesteryl esters were detected only in tumor lesions at the highest grade of malignancy in cerebral, renal, and prostatic neoplastic tissues, further supporting the concept that they may participate in the aggressivity and progression of different tumors ( 31,(44)(45)(46)(47). In accordance with these different studies, the role of cholesteryl esters in cell proliferation and invasion was further demonstrated by culturing the nontumor cells expressing the wild-type CCK2R in the presence of cholesteryl oleate.…”

“…Increased production of cholesteryl esters, ACAT expression and activation has been measured in different human tumors compared with normal tissue. In addition, a greater capacity to esterify and accumulate cholesterol in tumor cells has been associated with a higher growth rate, suggesting a link between cholesteryl ester production and cell proliferation (28)(29)(30)(31)(32).…”

Met Proto-Oncogene and Insulin-Like Growth Factor Binding Protein 3 Overexpression Correlates with Metastatic Ability in Well-Differentiated Pancreatic Endocrine Neoplasms

“…Neoplastic growth requires the formation of new cell membranes, which are dependent upon cholesterol derivatives and subsequent phospholipid formation (31). Renal and brain cancer (32), for example, demonstrate alterations in cholesterol homeostasis that appear to influence cancer growth and metastatic behavior. Our study has identified the overexpression of LRP5 and solute carrier family 27 (SLC27A2), as well as the underexpression of RXRG, all of which influence lipid balance within the cell.…”

Acyl-coenzyme A: Cholesterol acyltransferase inhibitor Avasimibe affect survival and proliferation of glioma tumor cell lines

“…The presence of cholesteryl esters in malignant cerebral tumors may be related to vascular and/or cellular neoplastic proliferation in the tumor mass, two prerequisites for tumor cell growth. 2 ACAT is an intracellular membrane-bound enzyme that uses cholesterol and long chain fatty acyl-CoA as substrates to produce cholesteryl esters. 3 ACAT activity is present in various tissues such as liver, intestines, adrenal glands and aorta, and is involved in intracellular cholesterol storage.…”