Cholesteryl ester transfer protein, low density lipoprotein particle size and intima media thickness in patients with coronary heart disease

Tosheska, Katerina; Labudovic, Danica; Jovanova, Silvana; Jaglikovski, Branko; Alabakovska, S.

doi:10.17305/bjbms.2011.2569

Cited by 7 publications

(8 citation statements)

References 38 publications

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“…22 Small LDL size is also associated with thicker cIMT in middle age subjects with metabolic syndrome 23 and in patients with coronary artery disease. 24, 25 In subjects with T2DM, small LDL was more highly associated with cIMT than LDL-C 26 retaining significance even after adjustment for other risk factors. 27 The importance of LDL particle number and size are not entirely clear for subjects with T1DM as the DCCT/EDIC study found stronger relationship between cIMT and LDL-C than LDL-P or LDL-S. 28 Similar to our data, however, they found all lipid parameters related more strongly to the internal than the common carotid artery.…”

Section: Discussionmentioning

confidence: 96%

Lipoprotein particle number and size predict vascular structure and function better than traditional lipids in adolescents and young adults

Urbina

McCoy

Gao

et al. 2017

Journal of Clinical Lipidology

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Background In adults, dyslipidemia is associated with higher carotid thickness and arterial stiffness, predictors of CV events. In young subjects, lipid concentrations have not been consistently associated with vascular measures. Objective To compare nuclear magnetic resonance (NMR) measures of lipoprotein particle number (LDL-P, HDL-P, VLDL-P) and size (LDL-S, HDL-S, VLDL-S) to determine if they were associated with vascular measures more strongly than lipid concentrations (LDL-C, HDL-C, TG). Methods We evaluated 214 lean (L), 228 Obese (O) and 214 diabetic (T2DM) subjects age 10–24 years (33% male, 39% Caucasian). CV risk factors, vascular structure and arterial stiffness were measured. General linear models were constructed including demographics, risk factors and traditional or NMR lipid parameters. A composite vascular function score was developed as the outcome in receiver operator characteristic scores (ROC) for determining which lipid parameter was superior in predicting vascular damage. Results Risk factors worsened from L to O to T. However, LDL-C was similar in O and T while LDL-S differentiated the 3 groups (T>O>L, p≤0.0001). Models demonstrated the superiority of NMR values which entered for all but one vascular outcome and explained more of the variance than traditional lipid concentrations. ROC curves demonstrated that NMR values were superior in predicting vascular outcomes. Models stratified by race were similar but cut-points predicting vascular outcomes differed by race for TG, TG/HDL and VLDL. Conclusion Lipoprotein particle number and size are more strongly related to vascular structure and function than traditional lipid values. NMR lipid measures may be a better indicator of risk for target organ damage than traditional lipid measures in adolescents and young adults.

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Section: Discussionmentioning

confidence: 96%

Lipoprotein particle number and size predict vascular structure and function better than traditional lipids in adolescents and young adults

Urbina

McCoy

Gao

et al. 2017

Journal of Clinical Lipidology

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“…Our present results further confirmed that the plasma preβ1-HDL levels elevated with high CETP mass in patients with CAD. As we all known, CETP plays an important role in the transfer and exchange of CE and TG among lipoproteins, so that it affects lipid composition, concentration, particle size and function of lipoprotein [12]. In addition, it is now accepted that virtually all of the efflux mediated by the ABCA1 transporter goes to preβ1-HDL, which contains only one molecular species of protein, apoA-I.…”

Section: Discussionmentioning

confidence: 99%

“…It relates to particle size, lipid composition and function of lipoprotein [12]. CETP also plays a key role in reverse cholesterol transport (RCT) and development of atherosclerosis [13, 14].…”

Section: Introductionmentioning

confidence: 99%

Elevated levels of preβ1-high-density lipoprotein are associated with cholesterol ester transfer protein, the presence and severity of coronary artery disease

Niu

et al. 2017

Lipids Health Dis

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BackgroundPreβ1-high-density lipoprotein (preβ1-HDL), plays an important role in reverse cholesterol transport and exhibits potent risk for coronary artery disease (CAD). However, the association of plasma preβ1-HDL and cholesterol ester transfer protein (CETP) levels in CAD patients and the relationship of preβ1-HDL with extent of CAD are debatable.MethodsPreβ1-HDL and CETP levels were measured by enzymed-linked immunosorbent assay (ELISAs) in 88 acute coronary syndromes (ACS), 79 stable coronary artery disease (SCAD) patients and 85 control subjects. The correlation analyses, multiple linear regression analyses and logistic regression analyses were performed, respectively.ResultsThe preβ1-HDL and CETP levels in ACS patients were significantly higher than those in SCAD patients and both of them were higher than controls’. Preβ1-HDL levels were positively associated with CETP (R = 0.348, P = 0.000), the diameter of stenosis (R = 0.253, P = 0.005), the number of vessel disease (R = 0.274, P = 0.002) and Gensini score (R = 0.227, P = 0.009) in CAD patients. Stepwise multiple linear regression analyses showed that CETP was one of the determinants of preβ1-HDL levels. Logistic regression analysis revealed that elevated preβ1-HDL and CETP were potential risk factors for both ACS and SCAD.ConclusionThe elevated preβ1-HDL levels may change with CETP concentrations in CAD patients and were related to the presence and severity of CAD.

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“…We divided the table according to investigations showing an increase or a decrease in CETP levels in plasma. We observed that, in general, the variation in CETP had the tendency to bring about consistent changes in the plasma lipoprotein profile, namely high CETP tends to produce a pro‐atherogenic lipoprotein profile in 14 of 16 investigations . However, the degree of atherosclerosis worsened in eight of them only , diminished in four and was not modified in 3 .…”

Section: Resultsmentioning

confidence: 77%

The controversy over the use of cholesteryl ester transfer protein inhibitors: is there some light at the end of the tunnel?

Quintão

2016

Eur J Clin Investigation

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Background According to epidemiological studies, there is no clear relationship between the plasma cholesteryl ester transfer protein (CETP) concentration and the development of atherosclerosis in human populations. Although some studies suggest that increased CETP activity relates to undesirable profiles of plasma lipoproteins, promoting an anti-atherogenic plasma lipoprotein profile by drugs that inhibit CETP has not succeeded in preventing atherosclerosis in humans.

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Cholesteryl ester transfer protein, low density lipoprotein particle size and intima media thickness in patients with coronary heart disease

Cited by 7 publications

References 38 publications

Lipoprotein particle number and size predict vascular structure and function better than traditional lipids in adolescents and young adults

Lipoprotein particle number and size predict vascular structure and function better than traditional lipids in adolescents and young adults

Elevated levels of preβ1-high-density lipoprotein are associated with cholesterol ester transfer protein, the presence and severity of coronary artery disease

The controversy over the use of cholesteryl ester transfer protein inhibitors: is there some light at the end of the tunnel?

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