Cholesteryl ester transfer protein (CETP), HDL capacity of receiving cholesterol and status of inflammatory cytokines in patients with severe heart failure

Abstract

BackgroundHeart failure (HF) courses with chronic inflammatory process and alterations in lipid metabolism may aggravate the disease. The aim was to test whether the severity of HF, using brain natriuretic peptide (BNP) as a marker, is associated with alterations in functional aspects of HDL, such as lipid transfer, cholesterol ester transfer protein (CETP) and lecithin-cholesterol acyltransferase (LCAT) concentration.MethodsTwenty-five HF patients in NYHA class I/II and 23 in class III/IV were enrolled. Plasma lipids, apolipoproteins, CETP, LCAT, oxidized-LDL (oxLDL) and paraoxonase-1 (PON-1) activity were determined. Lipid transfer from a donor artificial nanoparticle to HDL was measured by in vitro assay.ResultsTotal cholesterol (p = 0.049), LDL-C (p = 0.023), non-HDL-C (p = 0.029) and CETP, that promotes lipid transfer among lipoproteins (p = 0.013), were lower in III/IV than in I/II group. Triglycerides, HDL-C, apo A-I, apo B, oxLDL, LCAT, enzyme that catalyzes serum cholesterol esterification, PON-1 activity, and in vitro transfers of cholesterol, triglycerides and phospholipids to HDL, important steps in HDL metabolism, were equal. IL-8 was higher in III/IV (p = 0.025), but TNFα, IL-1β, IL-6 and MCP-1 were equal. BNP was negatively correlated with CETP (r = − 0.294; p = 0.042) and positively correlated with IL-8 (r = 0.299; p = 0.039).ConclusionsOur results disclosed the relationship between CETP levels and HF severity, by comparing two HF groups and by correlation analysis. Lower CETP levels may be a marker of HF aggravation and possibly of worse prognosis. Practical applications of this initial finding, as the issue whether CETP could be protective against HF aggravation, should be explored in larger experimental and clinical studies.

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“…FETUB is involved in fatty acid metabolism and can suppress inflammation via inhibiting merprins (Choi et al, 2012;Karmilin et al, 2019;Meex et al, 2015). CETP promotes lipid transfer between lipoproteins and can act as an inhibitor of prolonged inflammatory response, and the reduction of plasma CETP was associated with mortality in patients with severe sepsis (Martinelli et al, 2018;Venancio et al, 2016). PI6 has been found to suppress chemotaxis of some leukocytes, macrophages, and dendritic cells by inhibiting the chemokine chemerin (Regn et al, 2016).…”

Acute thermal stress promotes morphological and molecular changes in the heart of broiler chickens

“…An example is the cholesteryl ester transfer protein (CETP) whose action is considered pro-atherogenic. This enzyme acts by transferring the esterified cholesterol of high-density lipoproteins (HDL) while receiving triglycerides from low density lipoproteins (LDL), intermediate density (LDL) and very low density (VLDL) (Martinelli et al, 2018).…”

Plasma lipidomic biomarker analysis reveals distinct lipid changes in vascular dementia

“…A previous study in type 1 diabetic subjects showed that LCAT activity was positively correlated with cholesterol ester transfer protein (CETP) activity, total cholesterol, free cholesterol, LDL-C, CETP concentration, and LDL-cholesteryl ester, while it was negatively correlated with cholesteryl ester to free cholesterol ratio [55] . As well, increased serum cholesterol esterification rate has been shown to be an important predictor for developing diabetes [55] , [56] . These results suggest that accelerated LCAT and CETP may be due to increased accumulation of LDL-ChE in diabetes but not VaD.…”