Cholesterol Transport Dysfunction and Its Involvement in Atherogenesis

Poznyak, Anastasia V.; Kashirskikh, D.A.; Sukhorukov, Vasily N.; Kalmykov, Vladislav; Omelchenko, A. V.; Orekhov, Alexander N.

doi:10.3390/ijms23031332

Cited by 16 publications

(5 citation statements)

References 64 publications

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“…Interestingly, HDL increases the clearance of LPS via SR‐B1, which acts as an LPS‐binding protein 41 . Therefore, low HDL is negatively correlated with sepsis and augments systemic inflammatory reactions as HDL‐SR‐B1 acts as direct anti‐inflammatory agent‐driven cholesterol for glucocorticoid synthesis 62,63 . Van‐Leeuwen and colleagues observed that HDL serum levels rapidly declined in patients with severe sepsis, 64 suggesting a protective role of HDL against bacterial sepsis.…”

Section: Main Textmentioning

confidence: 99%

“…41 Therefore, low HDL is negatively correlated with sepsis and augments systemic inflammatory reactions as HDL-SR-B1 acts as direct anti-inflammatory agent-driven cholesterol for glucocorticoid synthesis. 62,63 Van-Leeuwen and colleagues observed that HDL serum levels rapidly declined in patients with severe sepsis, 64 suggesting a protective role of HDL against bacterial sepsis. Furthermore, it was observed that administration of reconstituted HDL can attenuate LPS-induced inflammation 64 proposed that HDL could be a valuable therapeutic approach for sepsis.…”

Section: Dysfunctional Hdl In Infections and Immune Disordersmentioning

confidence: 99%

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SARS‐CoV‐2 induced HDL dysfunction may affect the host's response to and recovery from COVID‐19

Al-Kuraishy

Hussien²,

Al-Niemi³

et al. 2023

Immunity Inflam & Disease

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Introduction: Covid-19 is linked with the development of cardio-metabolic disorders, including dyslipidemia, dysregulation of high-density lipoprotein (HDL), and low-density lipoprotein (LDL). Furthermore, SARS-Co-2 infection is associated with noteworthy changes in lipid profile, which is suggested as a possible biomarker to support the diagnosis and management of Covid-19.Methods: This paper adopts the literature review method to obtain information about how Covid-19 affects high-risk group patients and may cause severe and critical effects due to the development of acute lung injury and acute respiratory distress syndrome. A narrative and comprehensive review is presented. Results: Reducing HDL in Covid-19 is connected to the disease severity and poor clinical outcomes, suggesting that high HDL serum levels could benefit Covid-19. SARS-CoV-2 binds HDL, and this complex is attached to the co-localized receptors, facilitating viral entry. Therefore, SARS-CoV-2 infection may induce the development of dysfunctional HDL through different

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Section: Main Textmentioning

confidence: 99%

Section: Dysfunctional Hdl In Infections and Immune Disordersmentioning

confidence: 99%

SARS‐CoV‐2 induced HDL dysfunction may affect the host's response to and recovery from COVID‐19

Al-Kuraishy

Hussien²,

Al-Niemi³

et al. 2023

Immunity Inflam & Disease

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“…Atherosclerosis is a complex progressive disease affecting larger- and medium-sized arteries, contributing to many types of CVDs, including myocardial infarction and ischemic HF [ 44 ]. A consensus has been reached that atherosclerosis consists of three main phases: (1) a long asymptomatic initial stage with fatty streaks; (2) a progression stage characterized by the formation of atheromatous plaques over several decades; and (3) plaques-related complications, including plaque erosion or rupture, thrombus formation, and complete or near-complete vascular occlusion [ 43 ].…”

Section: Interaction Of the Ups And Oxidative Stress In Cvdsmentioning

confidence: 99%

Intersection of the Ubiquitin–Proteasome System with Oxidative Stress in Cardiovascular Disease

Qiu

Chen²,

Li³

et al. 2022

IJMS

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Cardiovascular diseases (CVDs) present a major social problem worldwide due to their high incidence and mortality rate. Many pathophysiological mechanisms are involved in CVDs, and oxidative stress plays a vital mediating role in most of these mechanisms. The ubiquitin–proteasome system (UPS) is the main machinery responsible for degrading cytosolic proteins in the repair system, which interacts with the mechanisms regulating endoplasmic reticulum homeostasis. Recent evidence also points to the role of UPS dysfunction in the development of CVDs. The UPS has been associated with oxidative stress and regulates reduction–oxidation homeostasis. However, the mechanisms underlying UPS-mediated oxidative stress’s contribution to CVDs are unclear, especially the role of these interactions at different disease stages. This review highlights the recent research progress on the roles of the UPS and oxidative stress, individually and in combination, in CVDs, focusing on the pathophysiology of key CVDs, including atherosclerosis, ischemia–reperfusion injury, cardiomyopathy, and heart failure. This synthesis provides new insight for continued research on the UPS–oxidative stress interaction, in turn suggesting novel targets for the treatment and prevention of CVDs.

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“…Research suggests that blood lipid profiles, which are a risk factor for CVD, are influenced by carbohydrate intake [ 2 , 8 ]. A high-carbohydrate diet may contribute to the development of atherosclerosis and various vascular diseases, ultimately leading to death [ 9 , 10 ]. Therefore, understanding the dietary patterns of different cultures is crucial in developing effective prevention strategies for chronic diseases.…”

Section: Introductionmentioning

confidence: 99%

Carbohydrate Intake and Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis of Prospective Studies

Park

2023

Nutrients

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The purpose of this study is to understand the conflicting results from previous studies on the association between carbohydrate intake and cardiovascular disease (CVD) by conducting a systematic review and meta-analysis to summarize the most recent scientific evidence. A systematic review used three electronic databases to gather literature on the association between carbohydrate intake and CVD. Considering the discrepancies, either fixed or random effect models were chosen to determine the effect size, and sensitivity analysis results, as well as publication bias, were also presented. The meta-analysis found that individuals with the highest carbohydrate intake had a 1.15-fold increased risk of CVD compared to those with the lowest intake (hazard ratio, HR: 1.15, 95% confidence interval, CI: 1.07–1.23). Further subgroup analysis revealed that this association was only present in Asia, with a 1.52-fold increased risk (HR: 1.52, 95% CI: 1.17–1.97), while no associations were seen in the Americas, Europe, and Oceania. The relationship between carbohydrate intake and CVD was non-linear, with a marked escalation beyond 60% of total energy from carbohydrates. Our findings suggest that a high-carbohydrate diet may raise the risk of CVD, particularly in Asian populations. This association may be due to the higher carbohydrate consumption and genetic variations found in Asia.

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Cholesterol Transport Dysfunction and Its Involvement in Atherogenesis

Cited by 16 publications

References 64 publications

SARS‐CoV‐2 induced HDL dysfunction may affect the host's response to and recovery from COVID‐19

SARS‐CoV‐2 induced HDL dysfunction may affect the host's response to and recovery from COVID‐19

Intersection of the Ubiquitin–Proteasome System with Oxidative Stress in Cardiovascular Disease

Carbohydrate Intake and Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis of Prospective Studies

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