Cholesterol Storage and Progestin Secretion During Pregnancy and Pseudopregnancy in the Rabbit

Hilliard, Jessamine; Spies, Harold G.; Sawyer, Charles H.

doi:10.1210/endo-82-1-157

Cited by 75 publications

(33 citation statements)

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“…The secretion of progesterone increases steadily in the first week of pregnancy and becomes maximal during the third week (Mikhail, Noall, and Allen 1961;Hilliard, Spies, and Sawyer 1968). The increased oxygen consumption and decreased lactate production of endometrial tissue from pregnant and pseudopregnant rabbits in the present investigation may, therefore, reflect changes in the activities of progesteronedependent enzymes such as succinic dehydrogenase and lactic dehydrogenase (Hafez and White 1967;Murdoch and White 1969).…”

Section: Discussionmentioning

confidence: 68%

“…The effects of HOG on secretion and endometrial metabolism may result from the action ofthe progestin, 20a-hydroxypregn-4-en-3-one (20a-OHP), which is secreted by the ovarian interstitium in response to the luteinizing hormone (LH) properties of the gonadotrophin (Simmer, Hilliard, and Archibald 1963;Hilliard, Penardi, and Sawyer 1967;Hilliard, Spies, and Sawyer 1968). The concentration of 20a-OHP is increased in the ovarian venous effluent within minutes after coitus or LH injection and high levels continue throughout most of the preovulatory period.…”

Section: Discussionmentioning

confidence: 99%

“…The concentration of 20a-OHP is increased in the ovarian venous effluent within minutes after coitus or LH injection and high levels continue throughout most of the preovulatory period. Although Hilliard, Penardi, and Sawyer (1967) have indicated that the progestin appears to playa positive role in prolonging LH discharge from the pituitary gland in the mated rabbit, the extent to which it participates in regulating endometrial metabolism is essentially unknown and further studies are clearly warranted.…”

Section: Discussionmentioning

confidence: 99%

“…Except where noted, centrifuging was carried out at 4°C for 10 min at 1000 g, and the separation was based on a procedure described by Hutchinson and Munro (1961).…”

Section: (C) Separation Oj Tissue Fractionsmentioning

confidence: 99%

“…and in the ovarian vein (Hilliard, Endroczi, and Sawyer 1961) ofthe rabbit. Moreover, recent studies of enzymes in the endometrium have shown that the activities of glucose-6-phosphate dehydrogenase and a number of other carbohydrate-metabolizing enzymes are dependent on progesterone (Hafez and White 1967;Murdoch and White 1969) and are altered by pregnancy and pseudopregnancy.…”

mentioning

confidence: 95%

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Metabolism of Rabbit Endometrium Following The Administration of Human Chorionic Gonadotrophin and During Oestrus, Pseudopregnancy, and Pregnancy

Murdoch¹,

O’Shea²

1970

Aust. Jnl. Of Bio. Sci.

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SummaryChanges in endometrial metabolism which occur after the intravenous injection of human chorionic gonadotrophin and during pregnancy (day 9) and pseudo· pregnancy (day 9) in the rabbit have been measured. During in vitro incubation, the endometrium at all stages studied produced more isotopically labelled carbon dioxide from [1_14C]glucose than from [6-14C]glucose.The endometrium from does injected with human chorionic gonadotrophin either 5 or 10 hr before incubation incorporated less tritiated uridine into ribonucleic acid than did that from rabbits at oestrus. When a larger amount of uridine was added during incubation there was no effect from injection of gonadotrophin. These results were thought to show that the gonadotrophin resulted in the formation of a larger uridine pool in the endometrium. There was more fluid in the uterine horns of the rabbits injected with human chorionic gonadotrophin and the proportion of does showing this fluid was greater at 10 hr than at 5 hr after treatment.During pregnancy and pseudopregnancy, the endometrium increased its oxygen consumption and carbon dioxide production, but incorporated less glucose into lactate, lipid, ribonucleic acid, and protein.

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Section: Discussionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Except where noted, centrifuging was carried out at 4°C for 10 min at 1000 g, and the separation was based on a procedure described by Hutchinson and Munro (1961).…”

Section: (C) Separation Oj Tissue Fractionsmentioning

confidence: 99%

mentioning

confidence: 95%

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