Cholesterol Review: A Metabolically Important Molecule

Schade, David S.; Shey, Lynda; Eaton, R. Philip

doi:10.4158/ep-2020-0347

Cited by 133 publications

(105 citation statements)

References 52 publications

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“…AR signaling drives PCa and plays an essential role in the development and progression of the disease [ 42 , 43 , 44 , 45 , 46 , 47 ]. As an essential component in cell membranes [ 48 ], and a mediator of cell proliferation and inflammatory pathways [ 41 , 49 ], there are multiple ways cholesterol needs can be exploited to target PCa pathophysiology. Fortunately, this has led to investigations into potential therapies that either directly or indirectly affect cholesterol, which could potentially impact PCa progression.…”

Section: Background and Focus Of This Perspectivementioning

confidence: 99%

Inhibition of Scavenger Receptor Class B Type 1 (SR-B1) Expression and Activity as a Potential Novel Target to Disrupt Cholesterol Availability in Castration-Resistant Prostate Cancer

et al. 2021

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There have been several studies that have linked elevated scavenger receptor class b type 1 (SR-B1) expression and activity to the development and progression of castration-resistant prostate cancer (CRPC). SR-B1 facilitates the influx of cholesterol to the cell from lipoproteins in systemic circulation. This influx of cholesterol may be important for many cellular functions, including the synthesis of androgens. Castration-resistant prostate cancer tumors can synthesize androgens de novo to supplement the loss of exogenous sources often induced by androgen deprivation therapy. Silencing of SR-B1 may impact the ability of prostate cancer cells, particularly those of the castration-resistant state, to maintain the intracellular supply of androgens by removing a supply of cholesterol. SR-B1 expression is elevated in CRPC models and has been linked to poor survival of patients. The overarching belief has been that cholesterol modulation, through either synthesis or uptake inhibition, will impact essential signaling processes, impeding the proliferation of prostate cancer. The reduction in cellular cholesterol availability can impede prostate cancer proliferation through both decreased steroid synthesis and steroid-independent mechanisms, providing a potential therapeutic target for the treatment of prostate cancer. In this article, we discuss and highlight the work on SR-B1 as a potential novel drug target for CRPC management.

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Section: Background and Focus Of This Perspectivementioning

confidence: 99%

Inhibition of Scavenger Receptor Class B Type 1 (SR-B1) Expression and Activity as a Potential Novel Target to Disrupt Cholesterol Availability in Castration-Resistant Prostate Cancer

et al. 2021

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“…Kolesterol mudah terakumulasi dalam tubuh ketika konsumsi makanan berkolesterol tinggi, kurang aktivitas fisik, merokok, dan lain lain. Hal ini jika tidak dikendalikan dengan baik akan menyebabkan penyakit tidak menular atau penyakit degeneratif (Schade et al, 2020).…”

Section: Pendahuluanunclassified

Konsumsi Pisang dalam Menurunkan Kadar Kolesterol Darah

Prameswari

2021

JPPP

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Kolesterol termasuk golongan lemak yang di dalam sel terbagi atas LDL, HDL, dan trigliserida. Kadar kolesterol yang tinggi akan meningkatkan risiko terjadinya arteroskeloris sehingga dapat menyebabkan komplikasi serebrovaskuler, vaskuler perifer, dan koroner, seperti hipertensi, penyakit jantung, dan stroke. Diet yang dapat dilakukan untuk menurunkan kadar kolesterol darah adalah salah satunya adalah konsumsi pisang. Literature review ini bertujuan untuk membahas konsumsi pisang dalam menurunkan kadar kolesterol darah. Metode yang digunakan adalah metode literature review dari 32 artikel yang ditemukan melalui database NCBI, PubMed, Portal Garuda dan Google Scholar dengan kata kunci “hiperkolesterolemia”, “kolesterol”, dan “pisang” yang dianalisis dari tahun 1999 hingga 2021 dan hanya 19 artikel terpilih. Dari beberapa penelitian yang telah dilakukan, didapatkan hasil bahwa konsumsi pisang dapat menurunkan kadar kolesterol darah.

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“…Considera-se que a dieta hiperlipídica, rica em gordura saturada com alta taxa calórica, acarreta obesidade, aumento do colesterol total e da lipoproteína de baixa densidade (LDL), com risco maior de desenvolvimento de doença arterial coronariana (SCHADE et al, 2020).…”

Section: Introductionunclassified

“…Há redução nesta condição principalmente do tecido adiposo visceral, e da massa corporal (CASTOLDI et al, 2018). Além disso, o treino aeróbico promove aumento do HDL, responsável pela redução do colesterol total e nas paredes dos vasos sanguíneos (SCHADE et al, 2020).…”

Section: Introductionunclassified

Efeito protetor do treino aeróbico em ratos submetidos à dieta hiperlipídica e normolipídica mensurados pela análise do perfil lipídico e do processo inflamatório tecidual / Protective effect of aerobic training in rats submitted to hyperlipidic and normolipidic diets measured by the analysis of lipid profile and tissue inflammatory process

Magalhães¹,

Filho²,

Mariolani³

et al. 2021

Braz. J. Hea. Rev.

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Avaliar o efeito protetor do treino aeróbico em ratos submetidos a dieta hiperlipídica e padrão levando-se em consideração o ganho da massa corporal, o acúmulo do tecido adiposo visceral e o perfil lipídico sérico. Métodos: Trinta e seis ratos machos Wistar foram divididos nos grupos Dieta Padrão e Dieta Hiperlipídica, cada grupo com subgrupos sedentário e treinados com o mesmo protocolo aeróbico. O consumo calórico foi medido semanalmente. O colesterol total e os triglicerídeos séricos foram medidos na fase pré-treino, 8ª e 13ª semana. Logo após a eutanásia foi mensurada a massa corporal, dosada a lipoproteína de alta densidade (HDL), coletado o tecido adiposo para cálculo do percentual relativo à massa corporal e o músculo sóleo para análise morfométrica. Na análise estatística foram utilizados os Teste Kruskall-Wallis e Wilcoxon, adotando p<0,05. Resultados: Sem gerar diferenças nas massas corporal e do sóleo entre os subgrupos (p>0,05), o treino aeróbico reduziu o colesterol total em ambos os grupos (p<0,05). No grupo Hiperlipídico, o treino aeróbico aumentou o trofismo muscular (p<0,05). No grupo Padrão, o treino aeróbico aumentou o HDL, diminuiu o tecido adiposo relativo e a inflamação muscular (p<0,05). O grupo Hiperlipídico apresentou menor consumo calórico, maior nível de triglicerídeos séricos e maior quantidade de tecido adiposo total e relativo comparado ao grupo Padrão (p<0,05). Conclusão: O treino aeróbico reduziu o colesterol total em ambos os grupos, gerou hipertrofia muscular no grupo Hiperlipídico e reduziu o tecido adiposo relativo, a inflamação muscular e aumentou o HDL no grupo Padrão.

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Cholesterol Review: A Metabolically Important Molecule

Cited by 133 publications

References 52 publications

Inhibition of Scavenger Receptor Class B Type 1 (SR-B1) Expression and Activity as a Potential Novel Target to Disrupt Cholesterol Availability in Castration-Resistant Prostate Cancer

Inhibition of Scavenger Receptor Class B Type 1 (SR-B1) Expression and Activity as a Potential Novel Target to Disrupt Cholesterol Availability in Castration-Resistant Prostate Cancer

Konsumsi Pisang dalam Menurunkan Kadar Kolesterol Darah

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