Cholesterol Pleural Effusion

Coe, John E.; Aikawa, Jerry K.

doi:10.1001/archinte.1961.03620110103014

Cited by 49 publications

(23 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It has been suggested [19,20] that it could be due to the degradation of blood cells (red cells and leuko cytes) which contain high concentrations of this metabo lite as well as to a slowing of pleural fluid drainage as a result of pleural involvement [19]. In our study, as in oth ers [ 10], no corrrelation between pCHOL and the number of red cells or leukocytes has been found, so this does not seem to lead to increased pCHOL.…”

Section: Resultssupporting

confidence: 40%

Pleural Cholesterol in Differentiating Transudates and Exudates

Suay¹,

Moragón²,

Viedma³

et al. 1995

Respiration

View full text Add to dashboard Cite

Two hundred and four patients with pleural effusion were studied to investigate the utility of Light’s criteria and pleural fluid cholesterol level (pCHOL) in the identification of exudative pleural effusion (EPE) and transudative pleural effusion (TPE). There were 48 TPE, 56 tumor, 47 tuberculous, 30 metapneumonic and 23 miscellaneous patients. A value ≧ 54 mg/dl for pCHOL and > 0.32 for the pleura/serum cholesterol ratio (p/sCHOL) showed sensitivity (S) and specificity (Sp) of 95.5% and 91.6% for pCHOL, and 97.4% and 91.6% for p/sCHOL, respectively. Combined pCHOL and/or p/sCHOL showed a S of 98.7% and Sp of 89.5%. Light’s criteria achieved a S of 100% and Sp of 64.5%. Combined pCHOL and p/sCHOL revealed a similar accuracy to Light’s criteria in EPE diagnosis but was found to be more exact in TPE diagnosis.

show abstract

Section: Resultssupporting

confidence: 40%

Pleural Cholesterol in Differentiating Transudates and Exudates

Suay¹,

Moragón²,

Viedma³

et al. 1995

Respiration

View full text Add to dashboard Cite

show abstract

“…It is gen erally assumed to be a rare condition [2], but is prob ably more common than might be expected from the literature [3]. Chyliform pleural effusions have been recognized for more than a century [4].…”

Section: Introductionmentioning

confidence: 99%

“…The pro cess is apparently initiated by a pleurisy, most often of tuberculous or rheumatoid origin [5] and usually re quires several years to develop its typical features. The effusion is characterized by an excessive choles terol content which is independent of serum choles terol levels [2]. The origin of this cholesterol has not yet been elucidated but has most frequently been at tributed to the local degeneration of red and white blood cells [2,5].…”

Section: Introductionmentioning

confidence: 99%

“…The effusion is characterized by an excessive choles terol content which is independent of serum choles terol levels [2]. The origin of this cholesterol has not yet been elucidated but has most frequently been at tributed to the local degeneration of red and white blood cells [2,5]. A detailed analysis of the lipopro tein profile in chyliform effusions has not yet been re ported.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Lipoprotein Analysis in a Chyliform Pleural Effusion: Implications for Pathogenesis and Diagnosis

Hamm

Pfalzer²,

Fabel

1991

Respiration

View full text Add to dashboard Cite

A chyliform effusion is an uncommon high lipid pleural effusion that does not result from a leakage of the thoracic duct. Characteristically, it emerges from chronic pleurisy and contains high levels of cholesterol. The origin of this cholesterol is unknown, but it is often attributed to the degeneration of red and white blood cells. In this study we have carried out detailed lipoprotein analyses in a chyliform effusion, a chronic tuberculous effusion and three inflammatory effusions of recent onset, in an attempt to elucidate the process of cholesterol accumulation and possible lipoprotein alterations. Mean cholesterol was 92 mg/dl in the inflammatory exudates and 1,237 mg/dl in the chyliform effusion. In inflammatory effusions of recent onset most cholesterol was bound to low density lipoprotein (LDL) with corresponding apoprotein B levels. The chronic tuberculous exudate showed a shift of cholesterol binding towards high density lipoprotein (HDL). In the chyliform effusion most cholesterol was found in the HDL region. Our results suggest that in acute inflammation, the pleural barrier opens to plasma LDL. We hypothesize that in chronicity this cholesterol becomes trapped in the pleural space and undergoes a change in lipoprotein binding characteristics. In a chyliform effusion, cholesterol further accumulates and builds complexes containing triglycerides and proteins. In clinical routine, total cholesterol values above 200 mg/dl strongly suggest a chyliform effusion. Since triglyceride values may be as high as in chylous effusions ( > 110mg/dl), the diagnostic routine in all suspected high lipid effusions should involve cholesterol and triglyceride measurements

show abstract

“…It can occur when fluid has been present in the pleural space for a long time especially with fibrotic pleura [1,2]. The three most common causes of pseudochylothorax are tuberculous pleural effusion, therapeutic pneumothorax, and chronic rheumatoid pleurisy [1±4], but it can develop with other diseases which cause extensive fibrosis of the pleura [1].…”

mentioning

confidence: 99%

Physiotherapy and bronchial mucus transport

Schans¹,

Postma²,

Koeter³

et al. 1999

Eur Respir J

View full text Add to dashboard Cite

Cough and expectoration of mucus are the best-known symptoms in patients with pulmonary disease. The most applied intervention for these symptoms is the use of chest physiotherapy to increase bronchial mucus transport and reduce retention of mucus in the airways. Chest physiotherapy interventions can be evaluated using different outcome variables, such as bronchial mucus transport measurement, measurement of the amount of expectorated mucus, pulmonary function, medication use, frequency of exacerbation and quality of life. Measurement of the transport rate of mucus in the airways using a radioactive tracer appears to be an appropriate outcome variable for short-term studies. Evaluation of chest physiotherapy only with pulmonary function tests appears to be inadequate in short-term studies. The popularity of using pulmonary function tests is probably based more on the availability of the instruments than on a theoretical basis related to the question of chest physiotherapy improving mucus transport. Quality of life and progression of the disease are not often used as outcome variables, but it may be worthwhile to use these in the future.

show abstract

Cholesterol Pleural Effusion

Cited by 49 publications

References 7 publications

Pleural Cholesterol in Differentiating Transudates and Exudates

Pleural Cholesterol in Differentiating Transudates and Exudates

Lipoprotein Analysis in a Chyliform Pleural Effusion: Implications for Pathogenesis and Diagnosis

Physiotherapy and bronchial mucus transport

Contact Info

Product

Resources

About