Cholesterol metabolism in tumor microenvironment: cancer hallmarks and therapeutic opportunities
Wen Jiang,
Wei-Lin Jin,
A-Man Xu
Abstract:Cholesterol is crucial for cell survival and growth, and dysregulation of cholesterol homeostasis has been linked to the development of cancer. The tumor microenvironment (TME) facilitates tumor cell survival and growth, and crosstalk between cholesterol metabolism and the TME contributes to tumorigenesis and tumor progression. Targeting cholesterol metabolism has demonstrated significant antitumor effects in preclinical and clinical studies. In this review, we discuss the regulatory mechanisms of cholesterol … Show more
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